> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/shigellosis-a290ea4b-e718-5cd1-99f9-5e84119eb5d0 > Record changed: 2026-11-04 # Shigellosis Therapeutic area Gastroenterology Rare disease Yes ## Definition and classification **Definition** Shigellosis is a bacterial infection leading to dysentery and is caused by Shigella, which are small, ubiquitous Gram-negative bacteria belonging to the enterobacteria family. There are four species: S. dysenteriae, S. flexneri, S. boydii and S. sonnei, all of which cause bacillary dysentery and are strictly limited to human hosts. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Shigellosis **Therapeutic area** Gastroenterology ### Alternative names (5) - shigellosis - Shigella Sonnei Infection - Shigella boydii infectious disease - Shigella flexneri infectious disease - Shigella sonnei infectious disease ## Clinical profile **Severity** Severe ### Disease mechanisms (2) - Acquired - Inflammatory Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019345) ### All therapeutic areas (2) - Gastroenterology - Infectious Disease Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019345) ## Identifiers **MONDO ID** MONDO:0019345 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019345) **Parent condition** MONDO:0000314 ## Related records ### Broader conditions (23) - Acute diarrhea - Acute disease - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) - [Diarrheal disease](https://trialight.com/data/condition/diarrheal-disease-623389f5-2a35-5350-9dae-f2dc4bc0fc34.md) - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - Digestive system infectious disorder - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Dysentery - [Gastroenteritis](https://trialight.com/data/condition/gastroenteritis-6f158f22-dfd3-577b-847d-64d9cf80af87.md) - Gastrointestinal mucositis - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Inflammatory diarrhea - Inflammatory disease - Intestinal disorder - Intestinal infectious disease ### Trials (61) - A Baseline Study in Support of Clinical Evaluation of an Oral Shigella Vaccine Development in Africa - A Human Challenge Study to Assess Protection of a Shigella Tetravalent Bioconjugate Vaccine - A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults. - A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty Hospitals - A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants - A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants - A Study to Determine If a New Shigella Vaccine is Safe, Induces Immunity and The Best Dose Among Kenyan Infants - A Study to Evaluate Safety and Immunogenicity of 1 Booster Dose of 1790GAHB Vaccine in Healthy Adults Primed With 3 Doses of 1790GAHB Vaccine in Study H03\_01TP Compared to 1 Vaccination of 1790GAHB in Either Subjects Who Received Placebo in the Same Study or naïve Subjects Not Part of H03\_01TP Study - A Study to Evaluate the Efficacy, Safety and Immunogenicity of a Vaccine Designed to Protect Against Infection With Shigella Sonnei in Healthy Adults - A Study to Investigate the Safety and Immunogenicity of the SF2a-TT15 Synthetic Carbohydrate-based Conjugate Vaccine Against Shigella Flexneri 2a - Ciprofloxacin Versus Azithromycin for Children Hospitalised With Dysentery - Clinical Trial of the S. Flexneri-S. Sonnei Bivalent Conjugate Vaccine - Controlled Human Infection Model Challenge/Rechallenge - Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders - Dose Escalating Study of Intramuscular Invaplex\[AR-DETOX\] - Dose-Finding Study of Lyophilized Shigella Sonnei 53G Challenge Strain - Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years - Egg Intervention During Pregnancy in Indonesia - Enterics for Global Health (EFGH) - Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy Adults ### Approved drugs (2) - Andrographolide - Neoandrographolide ### Drugs in development (8) - Azithromycin Phase 2 - Azithromycin monohydrate Phase 2 - Ceftriaxone Phase 2 - [Ciprofloxacin](https://trialight.com/data/asset/ciprofloxacin-8dbb4fad-883a-4e58-8501-5887c084b0ef.md) Phase 1 - Sodium butyrate Phase 2 - [Sodium chloride](https://trialight.com/data/asset/sodium-chloride-a67c33bc-45ef-42e4-8022-d121f0a86585.md) Phase 2 - Tebipenem pivoxil Phase 2 - Zinc acetate Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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