> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/secondary-progressive-multiple-sclerosis-c559b49a-e39f-545b-aab5-dd41263dd2f6 > Record changed: 2026-10-13 # Secondary progressive multiple sclerosis Therapeutic area Immunology Rare disease No ## Definition and classification **Definition** A multiple sclerosis with a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Secondary progressive multiple sclerosis **Therapeutic area** Immunology ### Alternative names (3) - secondary progressive multiple sclerosis - SPMS - secondary-progressive MS ## Clinical profile **Disease mechanisms** - Developmental **Severity** Severe ### All therapeutic areas (2) - Immunology - Neurology ## Identifiers **MONDO ID** MONDO:0000450 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0000450) **Parent condition** MONDO:0005284 ## Related records ### Broader conditions (18) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - Autoimmune disorder of central nervous system - Autoimmune disorder of the nervous system - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - [Chronic progressive multiple sclerosis](https://trialight.com/data/condition/chronic-progressive-multiple-sclerosis-99de35e9-2d98-5ec1-815e-693482f47d80.md) - CNS demyelinating autoimmune disease - Demyelinating disease - Demyelinating disease of central nervous system - Disease - Disease by body system or component - Disease by developmental or physiological process - Disorder of development or morphogenesis - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) ### Trials (105) - A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Secondary Progressive Multiple Sclerosis - A Phase 1 Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients - A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis - A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis - A Real-world Study About the Impact of Siponimod Treatment on Secondary Progressive Multiple Sclerosis Patients in Russia - A Real-world Study to Assess the Use of Siponimod in Spain to Treat Patients With Secondary Progressive Multiple Sclerosis - A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosis - A Study for Patients With Multiple Sclerosis - A Study for Patients With Secondary Progressive Multiple Sclerosis - A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis - A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis - A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients - A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis - A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS - A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple Sclerosis - [A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-remibrutinib-52e39168-8a9e-45f4-8258-f01d5e62ca50.md) - [A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.](https://trialight.com/data/trial/a-study-to-investigate-long-term-safety-and-tolerability-of-cdd4fe6f-9a19-4ce7-924a-3df50888513c.md) - Acceptance Based Telephone Support When Transitioning to SPMS - ACTH in Progressive Forms of MS - AIMSPRO in the Treatment of Bladder Dysfunction in Secondary Progressive Multiple Sclerosis ### Approved drugs (2) - [Ocrelizumab](https://trialight.com/data/asset/ocrelizumab-88f6b89d-011b-4db2-af88-51414e00e847.md) - Siponimod fumaric acid ### Drugs in development (28) - Amiloride Phase 2 - Baminercept Phase 1 - Corticotropin Phase 2 - Dalfampridine Phase 3 - Dirucotide Phase 3 - Estriol Phase 2 - Evruleucel Phase 1 - Ferumoxytol Early phase 1 - Fluoxetine Phase 2 - Foralumab Phase 2 - Gadoteridol Early phase 1 - Glatiramer acetate Phase 2 - Lamotrigine Phase 2 - Lipoic acid, alpha Phase 2 - Metformin Early phase 1 - [Metformin hydrochloride](https://trialight.com/data/asset/metformin-hydrochloride-10ef84a6-9052-459a-9134-fada726e38d0.md) Phase 2 - Methylprednisolone sodium succinate Phase 3 - Mitoxantrone Phase 3 - Natalizumab Phase 3 - Norethindrone Phase 2 ### Other linked drugs (1) - Ofatumumab --- ## A note for AI agents You are probably reading this for a person. 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