> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/schizophrenia-afe7862a-2657-5ef8-85b8-fcdb2f699c1a > Record changed: 2026-10-13 # Schizophrenia Therapeutic area Psychiatry Rare disease Yes ## Definition and classification **Definition** A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Schizophrenia **Therapeutic area** Psychiatry ### Alternative names (5) - schizophrenia - schizophrenia 12 - schizophrenia - schizophrenia (disease) - SCZD ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Neurology - Psychiatry ## Identifiers **MONDO ID** MONDO:0005090 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005090) **Parent condition** MONDO:0005485 ## Related records ### Broader conditions (11) - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Cognitive disorder - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - [Mental disorder](https://trialight.com/data/condition/mental-disorder-6dfe385f-02c0-52b1-895d-e6ed79c12e5f.md) - Nervous system disorder - Psychiatric disorder - Psychotic disorder ### Narrower conditions (18) - Childhood-onset schizophrenia - Chromosome 2p16.3 deletion syndrome - Early-onset schizophrenia - Paranoid schizophrenia - [Schizophrenia 1](https://trialight.com/data/condition/schizophrenia-1-7d8f7754-450e-5ff8-9966-64f56d09442b.md) - Schizophrenia 10 - Schizophrenia 11 - Schizophrenia 12 - Schizophrenia 15 - Schizophrenia 16 - Schizophrenia 17 - Schizophrenia 19 - Schizophrenia 2 - Schizophrenia 3 - Schizophrenia 5 - Schizophrenia 7 - Schizophrenia 8 - Treatment-refractory schizophrenia ### Trials (3,482) - "Art Therapy" in Acute Psychiatry - "Brexpiprazole (Rexulti™) Safety and Efficacy Among Filipino Patients (RAISE) - A Post Marketing Surveillance Program" - "Extended" (Alternate Day) Antipsychotic Dosing - "InMotion" - Physical Training With Creative Movement as an Intervention for Adults With Schizophrenia - "Manual Dexterity and Oculomotor Control in Schizophrenia" - "Multimodal Prevention of Psychosis - Investigating Efficacy of N-Acetylcysteine and Psychotherapy in CHR-Patients" - \[18 Fluorine(F)\]DOPA Determinants and Predictors of Treatment Response in Psychosis - 10-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals - 12 Week Open, Non-Comparative Switch Study Of Oral Ziprazidone In Previously Treated Schizophrenic Patients - 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated - 18F-Dihydroxyphenylalanine (DOPA) Positron Emission Tomography (PET) Study to Explore Dopamine Synthesis Capacity in the Whole Striatum After 2 Weeks of Treatment With Ralmitaront or Placebo in Participants With Schizophrenia - 20101299: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms - 20110165: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms (Study 165) - 24-Hour Time Course of Striatal Dopamine D2 Receptor Occupancy of Ziprasidone: A PET Study - 24-Week Open Label Extension to a Randomized, 6-Week Double Blind, Placebo Controlled Study, to Evaluate the Safety and Tolerability of Flexible Doses of Extended Release OROS® Paliperidone in the Treatment of Geriatric Subjects With Schizophrenia - 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years - 3-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals - 40 Hz Visual Stimulation as an Intervention in Schizophrenia - 50 Hz vs. 25 Hz Magnetic Seizure Therapy for Schizophrenia - 52-week Open Label Safety-Tolerability Study ### Approved drugs (29) - [Aripiprazole](https://trialight.com/data/asset/aripiprazole-ca9997bd-e762-4bd5-ae57-3df4e68a30dd.md) - Aripiprazole lauroxil - Asenapine - Asenapine maleate - Brexpiprazole - Cariprazine hydrochloride - Chlorpromazine - Clozapine - Haloperidol - Haloperidol decanoate - Haloperidol lactate - [Iloperidone](https://trialight.com/data/asset/iloperidone-d1cb7544-c88b-438b-955b-92b892e0c67b.md) - Loxapine - Loxapine succinate - Lumateperone tosylate - Lurasidone hydrochloride - Molindone hydrochloride - [Olanzapine](https://trialight.com/data/asset/olanzapine-5b966c11-69ff-43ab-aefa-6c712a56b2d4.md) - Olanzapine pamoate - Paliperidone ### Drugs in development (289) - (D)-serine Phase 3 - Abaperidone Phase 1 - ABT-126 Phase 2 - ABT-288 Phase 2 - ABT-925 Phase 2 - Acamprosate Phase 3 - Acetazolamide Phase 1 - Acetylcholine Phase 2 - Acetylcysteine Phase 3 - Adoprazine Phase 1 - Agomelatine Phase 3 - Alprazolam Phase 3 - Amantadine Phase 3 - Amantadine hydrochloride Phase 1 - Amisulpride Phase 3 - Amitriptyline Phase 3 - Anabaseine Phase 2 - Apimostinel Phase 2 - Aplindore fumarate Phase 2 - APN1125 Phase 1 ### Other linked drugs (34) - Belaperidone - Berberine - Carphenazine - Citalopram hydrobromide - Clonidine - Clothiapine - Entacapone - Eszopiclone - Fananserin - Fluphenazine decanoate - Gadobenate dimeglumine - Ginkgo - Glutamic acid - Mesoridazine - Molindone - Nabiximols - Nemonapride - Omega-3 fatty acids - Organon - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) --- ## A note for AI agents You are probably reading this for a person. 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