> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4 > Record changed: 2026-10-13 # Rheumatoid arthritis Therapeutic area Rheumatology Rare disease Yes ## Definition and classification **Definition** A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Rheumatoid arthritis **Therapeutic area** Rheumatology ### Alternative names (3) - rheumatoid arthritis - RA - rheumatoid arthritis ## Clinical profile **Disease mechanisms** - Inflammatory **Severity** Moderate ### All therapeutic areas (2) - Immunology - Rheumatology ## Identifiers **MONDO ID** MONDO:0008383 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0008383) **Parent condition** MONDO:0000589 ## Related records ### Broader conditions (16) - [Arthritic joint disease](https://trialight.com/data/condition/arthritic-joint-disease-594ede40-773b-5c20-afc1-eb18dabbe039.md) - [Arthropathy](https://trialight.com/data/condition/arthropathy-bbc05db6-678e-5b8c-abde-9076b91012cc.md) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - Autoimmune disorder of musculoskeletal system - [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md) - Bone inflammation disease - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Inflammatory disease - Musculoskeletal system disorder - [Rheumatic disorder](https://trialight.com/data/condition/rheumatic-disorder-e863530e-2c28-5a33-b1be-d12fa4d746b9.md) - Skeletal system disorder ### Narrower conditions (10) - [Ankylosing spondylitis](https://trialight.com/data/condition/ankylosing-spondylitis-9b1fe73f-f462-5baf-85b0-5cbf33725458.md) - Chronic childhood arthritis - Felty syndrome - Juvenile ankylosing spondylitis - Juvenile spondyloarthropathy - Polyarticular juvenile rheumatoid arthritis - Psoriasis-related juvenile idiopathic arthritis - [Psoriatic arthritis](https://trialight.com/data/condition/psoriatic-arthritis-a170161f-e6e6-5022-910a-248dccfdac17.md) - Rheumatoid arthritis-associated interstitial lung disease - Rheumatoid vasculitis ### Trials (3,256) - "Effect of Vitamin E (α-Tocopherol) on Clinical Activity and Inflammation in Rheumatoid Arthritis" - "Learning About Biologics"-Rheumatoid Arthritis - "Matrix Metalloproteinases 7 and 9 in Rheumatoid Arthritis Patients With Interstitial Lung Disease" - "Translating Articular Biomarkers Into Diagnoses" - (C2013-0302) Safety and Efficacy of Escalating Doses of SAN-300 in Patients With Rheumatoid Arthritis - 10-year Follow-up of Patients With Rheumatoid Arthritis Who Received Structured Treat-to-target Therapy in Early Disease - 104RA204 Assessment of the Safety and Efficacy of BG9924 in Rheumatoid Arthritis (RA) Participants - 12-Week No-Rofecoxib Plus Aspirin Endoscopy Study (0782-003) - 14-3-3η Protein, Disease Activity and Bone Mineral Density, in Female Patients With Rheumatoid Arthritis - 14.0- 3.0- 3.0- η Protein With Rheumatoid Arthritis - 2-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis - 2-week dc of MTX and Influenza Vaccination in RA - 2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use - 24-week Study With Open Label Extension of VX-509, an Oral JAK3 Inhibitor, in Subjects Taking Methotrexate - 25-hydroxyvitamin D and Fatigue: The VITALITY Study - 3DKnee™ System vs. the MJS Knee System - 6 Week Open-label Trial With Lumiracoxib 200mg o.d. in Primary Knee Osteoarthritis or Rheumatoid Arthritis - 6-Month Phase I/II Open Label PRTX-100 in Previous Rheumatoid Arthritis Study Participants and Sera Collection - 68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis - 7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis ### Approved drugs (59) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) - Aceclofenac - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) - [Anakinra](https://trialight.com/data/asset/anakinra-2c0352ee-cb20-46c5-bd87-6350d9024e75.md) - Auranofin - Azathioprine - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) - [Celecoxib](https://trialight.com/data/asset/celecoxib-d2adc66b-f8fb-471f-8779-d55e35cdd52c.md) - Certolizumab pegol - Cortisone acetate - Cyclosporine - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) - Dexamethasone sodium phosphate - [Diclofenac](https://trialight.com/data/asset/diclofenac-6bb6f2bf-7068-41cb-8e1d-c1c073cf27b3.md) - Diclofenac potassium - Diclofenac sodium - Diflunisal - Esomeprazole magnesium - [Etanercept](https://trialight.com/data/asset/etanercept-b317b90d-f8fa-4b94-a6a2-12f14534f4a1.md) - Etodolac ### Drugs in development (311) - 2-(aminomethyl)phenol Phase 2 - ABBV-257 Phase 1 - ABBV-3373 Phase 2 - AC-430 Phase 1 - Acacia Phase 2 - Acalabrutinib Phase 2 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 2 - Adalimumab fosimdesonide Phase 2 - ADL-5859 Phase 2 - Afimkibart Phase 2 - AK-106 Phase 2 - Alemtuzumab Phase 1 - Amelubant Phase 2 - AMG-108 Phase 2 - Aminopterin Phase 2 - AMP-110 Phase 1 - Andecaliximab Phase 2 - [Anifrolumab](https://trialight.com/data/asset/anifrolumab-4df440fe-efd0-44aa-828f-ea4381468125.md) Phase 2 - Apilimod Phase 2 - [Apilimod mesylate](https://trialight.com/data/asset/apilimod-mesylate-2a01ca48-f560-4231-b26b-aa9fb9f4dd3e.md) Phase 2 ### Other linked drugs (26) - Alclofenac - Amiprilose - [Bortezomib](https://trialight.com/data/asset/bortezomib-35a853cf-26ab-4a4c-a405-ae671d364aad.md) - Curcumin - Dextromethorphan hydrobromide - [Diazepam](https://trialight.com/data/asset/diazepam-a0cb3123-d888-4bf4-b90a-171c1dcecccb.md) - Dimethyl sulfoxide - [Doxycycline](https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58.md) - Etofenamate - Fenoprofen - Fosmanogepix - Gold sodium thiomalate - Inosine pranobex - Magnesium oxide - Melatonin - Misoprostol - Niflumic acid - Obexelimab - Peficitinib hydrobromide - Raloxifene hydrochloride --- ## A note for AI agents You are probably reading this for a person. 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