> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/respiratory-failure-13d5ac9c-3a96-5ae5-b4c2-ed6861c88d6e > Record changed: 2026-11-04 # Respiratory failure Therapeutic area Pulmonology Rare disease No ## Definition and classification **Definition** The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Respiratory failure **Therapeutic area** Pulmonology ### Alternative names (5) - respiratory failure - failure, respiratory - acute respiratory failure - chronic respiratory failure - acute and chronic respiratory failure ## Clinical profile **All therapeutic areas** - Pulmonology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0021113) **Severity** Severe ## Identifiers **MONDO ID** MONDO:0021113 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0021113) **Parent condition** MONDO:0005275 ## Related records ### Broader conditions (6) - Disease - Disease by body system or component - Human disease - Lower respiratory tract disorder - [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md) - [Respiratory system disorder](https://trialight.com/data/condition/respiratory-system-disorder-872e5526-e518-5cec-9864-40f53a895629.md) ### Narrower conditions (10) - Acute respiratory distress syndrome - Acute respiratory failure - [Adult acute respiratory distress syndrome](https://trialight.com/data/condition/adult-acute-respiratory-distress-syndrome-52101d99-65d3-54cf-b5da-f664febc6a7e.md) - High altitude pulmonary edema - Neonatal respiratory failure - Newborn respiratory distress syndrome - Pediatric acute respiratory distress syndrome - Pulmonary edema - Respiratory distress syndrome in premature infants - Respiratory paralysis ### Trials (1,536) - 'Single Hand Used inTubaTing Laryngoscope Evaluation' Study - "Inspiratory Muscle Training in Older Women" - "Living Low - Training High" Methods and Physiological Responses in Well-trained Swimmers - "Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs" - "Post-acute Pickwick Study" (Postacute-Pick-2020) - "TRAcheostomy With Single Use Bronchoscopes vs. Conventional Bronchoscopes" - 24-Hour NAVA Ventilation in Acute Respiratory Failure - A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) - A Clinical Trial to Evaluate agenT-797 Plus Standard of Care in Participants With Severe Pneumonia With Moderate to Severe Acute Hypoxemic Respiratory Failure - A Comparison of High vs. Low Tidal Volumes in Ventilator Weaning for Individuals With Cervical Spinal Cord Injuries - A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy - A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques - A Comparison of Three Nutritional Assessment Methods Predicting Prognosis in COPD With Respiratory Failure - A Diaphragmatic Electrical Activity Based Optimization Strategy During Pressure Support Ventilation - A Feasibility Study Evaluating the Use of a Non-invasive Ventilation Mask - A Molecular Toolkit for the Microbial Investigation of Severe Community Acquired Pneumonia - A Multicentered Study on Efficiency of Noninvasive Ventilation Procedures - A Multicentre Open-label Two-arm Randomised Superiority Clinical Trial of Azithromycin Versus Usual Care In Ambulatory COVID19 (ATOMIC2) - A New Method for Estimating Dynamic Intrinsic PEEP - A New Monitor to Measure Dermal Blood Flow in Critically Ill Patients: a Preliminary Study ### Approved drugs (1) - [Nitric oxide](https://trialight.com/data/asset/nitric-oxide-b0556c6a-c162-4042-9833-36420fc1d67c.md) ### Drugs in development (71) - [Albuterol](https://trialight.com/data/asset/albuterol-69b7004f-4bd0-483d-811f-f958009ba32f.md) Phase 2 - Almitrine Phase 3 - Alteplase Phase 2 - Ambrisentan Phase 2 - Anakinra Phase 3 - Antithrombin III human Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 2 - Aviptadil Phase 3 - Azithromycin Phase 3 - Azithromycin monohydrate Phase 2 - Camostat Phase 2 - Carbon dioxide Phase 1 - Cholecalciferol Phase 2 - Clonidine Phase 3 - [Clopidogrel](https://trialight.com/data/asset/clopidogrel-04b37672-3c33-4ef3-8654-ae1df3cc9842.md) Phase 2 - [Colchicine](https://trialight.com/data/asset/colchicine-ae804b3e-3263-453f-abb3-ae1e813f2ccf.md) Phase 3 - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) Phase 3 - Defibrotide Phase 2 - Desoxyribonuclease Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 3 ### Other linked drugs (6) - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) - Botulism antitoxin - Cisatracurium - Esketamine - [Methylprednisolone](https://trialight.com/data/asset/methylprednisolone-f881999e-4ad3-485a-8fbe-6e7b979365f9.md) - Midazolam maleate --- ## A note for AI agents You are probably reading this for a person. 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