> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/pyelonephritis-3fc522f3-1bbe-5d31-9ffb-eacaa85f46c4 > Record changed: 2026-11-04 # Pyelonephritis Therapeutic area Nephrology Rare disease No ## Definition and classification **Definition** An inflammatory process affecting the kidney. The cause is most often bacterial, but may also be fungal in nature. Signs and symptoms may include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Pyelonephritis **Therapeutic area** Nephrology ### Alternative names (3) - pyelonephritis - kidney infection - pyometrium ## Clinical profile **Severity** Severe ### Disease mechanisms (2) - Acquired - Inflammatory Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006939) ### All therapeutic areas (3) - Infectious Disease - Nephrology - Reproductive Health Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006939) ## Identifiers **MONDO ID** MONDO:0006939 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006939) **Parent condition** MONDO:0001786 ## Related records ### Broader conditions (20) - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) - Bacterial urinary tract infection - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Female reproductive system disorder - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Inflammatory disease - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) - [Nephritis](https://trialight.com/data/condition/nephritis-58f31f23-e5c1-5fa9-a945-53ea4e1ef653.md) - Pyelitis - Renal infectious disease - Reproductive system disorder - [Urinary system disorder](https://trialight.com/data/condition/urinary-system-disorder-68e8d758-aac9-544b-8378-87fe59b2c7b0.md) - [Urinary tract infection](https://trialight.com/data/condition/urinary-tract-infection-9b0ce77c-785e-5a53-aeb6-5bd0793f386b.md) - [Uterine disorder](https://trialight.com/data/condition/uterine-disorder-91bd2ecb-b4eb-5d37-848d-f1a02445c858.md) - Uterine inflammatory disease ### Narrower conditions (3) - [Acute pyelonephritis](https://trialight.com/data/condition/acute-pyelonephritis-83bd05de-bc8b-595e-ba5a-ab06709e6b77.md) - Chronic pyelonephritis - Xanthogranulomatous pyelonephritis ### Trials (77) - 7-day Compared With 10-day Antibiotic Treatment for Febrile Urinary Tract Infections in Children - A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. - A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux - A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections - A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP) - A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) - A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections - A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Meropenem-Vaborbactam in Children With Complicated Urinary Tract Infection, Including Acute Pyelonephritis - A Study to Investigate PK, Safety, Tolerability of Cefepime-enmetazobactam in Pediatric Participants With cUTI - A Study to Learn About the Study Medicine Zavicefta After it is Released Into the Markets in Korea - Antibiotic Education for Children in an Emergency Care Unit - Antibiotic Prophylaxis in Children With Pyelonephritis - Antibiotic Treatment Versus no Therapy in Kidney Transplant Recipients With Asymptomatic Bacteriuria - Bacterial Metallophores in the Diagnosis of Acute Pyelonephritis - Bedside Ultrasonography in Acute Patients With Suspected Kidney Involvement - Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens - Cefuroxime Resistance in Pyelonephritis - Clinical Performance Evaluation of the QIAstat-Dx® cUTI Plus AMR - Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis - Clinical Utility of a PCR Compared to Culture and Sensitivity Testing for the Management of cUTI in Adults. ### Approved drugs (16) - Avibactam sodium - Aztreonam - Cefepime hydrochloride - [Ceftazidime](https://trialight.com/data/asset/ceftazidime-26aab43b-d019-49e2-8652-af26e1e98cc0.md) - Ceftazidime sodium - Ceftolozane sulfate - [Ciprofloxacin](https://trialight.com/data/asset/ciprofloxacin-8dbb4fad-883a-4e58-8501-5887c084b0ef.md) - Ciprofloxacin hydrochloride - Doripenem - Doripenem monohydrate - Enmetazobactam - Piperacillin - Piperacillin sodium - Plazomicin sulfate - Relebactam - Sitafloxacin ### Drugs in development (25) - Acetylcysteine Phase 2 - [Amoxicillin](https://trialight.com/data/asset/amoxicillin-09050e6a-69b4-42d1-b3eb-79212edcf388.md) Phase 3 - [Avibactam](https://trialight.com/data/asset/avibactam-6cfff504-ee0a-4c2e-be81-39d4e7db1239.md) Phase 3 - Benapenem Phase 2 - Cefepime Phase 3 - Ceftibuten Phase 3 - Ceftolozane Phase 3 - [Cilastatin](https://trialight.com/data/asset/cilastatin-90ee9774-cb9f-45bf-b8ba-c3544f68c87e.md) Phase 3 - Clavulanate potassium Phase 3 - Cycloserine Phase 2 - [Ertapenem](https://trialight.com/data/asset/ertapenem-f3871fea-2d09-4797-86f4-79efb2e4c8cd.md) Phase 2 - Flomoxef Phase 3 - [Imipenem](https://trialight.com/data/asset/imipenem-f7af1694-45a9-4315-b812-d17767d1ad0f.md) Phase 3 - Levocarnitine Phase 3 - [Levofloxacin](https://trialight.com/data/asset/levofloxacin-091d90d2-35bb-4b1e-b685-02b522e966f5.md) Phase 3 - Lurasidone Phase 2 - [Meropenem](https://trialight.com/data/asset/meropenem-a90880e5-37b0-473b-bf12-d5f0de7894c2.md) Phase 3 - Nacubactam Phase 1 - Omega-3-acid ethyl esters Phase 3 - [Probenecid](https://trialight.com/data/asset/probenecid-0864a3cb-3764-4994-8995-3400af689d1e.md) Phase 3 ### Other linked drugs (7) - Cefoxitin - [Clavulanic acid](https://trialight.com/data/asset/clavulanic-acid-465f3e04-3ad5-4ece-97cf-d63cae081959.md) - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) - [Empagliflozin](https://trialight.com/data/asset/empagliflozin-09301932-ac0f-4eb7-8d1d-bd13fdbb6ab8.md) - Linagliptin - Saxagliptin - Temocillin --- ## A note for AI agents You are probably reading this for a person. 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