> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/progressive-relapsing-multiple-sclerosis-3988455b-b8b3-5584-a1f4-703f7fdd9533 > Record changed: 2026-10-13 # Progressive relapsing multiple sclerosis Therapeutic area Immunology Rare disease No ## Definition and classification **Definition** A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Progressive relapsing multiple sclerosis **Alternative names** - progressive relapsing multiple sclerosis **Therapeutic area** Immunology ## Clinical profile **Disease mechanisms** - Developmental **Severity** Severe ### All therapeutic areas (2) - Immunology - Neurology ## Identifiers **MONDO ID** MONDO:0000452 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0000452) **Parent condition** MONDO:0005284 ## Related records ### Broader conditions (18) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - Autoimmune disorder of central nervous system - Autoimmune disorder of the nervous system - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - [Chronic progressive multiple sclerosis](https://trialight.com/data/condition/chronic-progressive-multiple-sclerosis-99de35e9-2d98-5ec1-815e-693482f47d80.md) - CNS demyelinating autoimmune disease - Demyelinating disease - Demyelinating disease of central nervous system - Disease - Disease by body system or component - Disease by developmental or physiological process - Disorder of development or morphogenesis - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) ### Trials (99) - 9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis - A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis - A Multicenter Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab - A Multicenter Study to Assess Response to Influenza Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab - A Multinational, Randomized, Double-blind, Parallel-group, Placebo-controlled Study Assessing the Safety and Tolerability - A NIS Evaluating Various Injectable and Oral Treatments in Patients With Relapsing Multiple Sclerosis - A Open-label Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab - A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS) - A Phase 2 Study of Atacicept in Subjects With Relapsing Multiple Sclerosis (ATAMS) - A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis - A Phase IV Study of Dimethyl Fumarate Enteric-coated Capsules for Relapsing Multiple Sclerosis (RMS) - A Single Arm Study Evaluating the Efficacy, Safety and Tolerability of Ofatumumab in Patients With Relapsing Multiple Sclerosis - A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk - A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS) - A Study of Immune Phenotype Biomarkers in Patients With Relapsing Multiple Sclerosis (RMS) After Treatment With 0.5mg Fingolimod - A Study of Mitoxantrone Hydrochloride Liposome Injection for Relapsing Multiple Sclerosis - A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone) - A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis - A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis - A Study of Pirtobrutinib (LY3527727 \[LOXO-305\]) Versus Placebo in Participants With Relapsing Multiple Sclerosis --- ## A note for AI agents You are probably reading this for a person. 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