> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/primary-central-nervous-system-lymphoma-0f3f2051-d8a7-5ab2-bc09-6bacfa58c99a > Record changed: 2026-10-13 # Primary central nervous system lymphoma Therapeutic area Immunology Rare disease Yes ## Definition and classification **Definition** A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Primary central nervous system lymphoma **Therapeutic area** Immunology ### Alternative names (12) - primary central nervous system lymphoma - CNS lymphoma - PCNSL - central nervous system lymphoma - lymphoma of central nervous system - malignant lymphomas of CNS - malignant lymphomas of the CNS - microglioma - primary CNS lymphoma - primary brain lymphoma - primary central nervous system lymphoma - primary lymphoma, CNS ## Clinical profile **Disease mechanisms** - Acquired **Severity** Severe ### All therapeutic areas (4) - Hematology - Immunology - Neurology - Oncology ## Identifiers **MONDO ID** MONDO:0002571 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0002571) **Parent condition** MONDO:0000621 ## Related records ### Broader conditions (33) - [B-cell neoplasm](https://trialight.com/data/condition/b-cell-neoplasm-ffd0710d-7dbd-55bc-a4a5-3c1cf532bac2.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Central nervous system cancer - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Central nervous system hematopoietic neoplasm - [Central nervous system neoplasm](https://trialight.com/data/condition/central-nervous-system-neoplasm-bd35c306-06e5-549c-a882-45bdfbcbb7d8.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Epstein-Barr virus-associated lymphoproliferative disorder - Epstein-Barr virus-related tumor - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - Immune system cancer - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Leukocyte disorder ### Narrower conditions (5) - Central nervous system anaplastic large cell lymphoma - Central nervous system non-hodgkin lymphoma - Cerebral lymphoma - Diffuse large B-cell lymphoma of the central nervous system - Spinal cord lymphoma ### Trials (193) - \[18F\]-Fludarabine PET/MRI in Primary Central Nervous System Lymphoma - \[68Ga\]Ga-PentixaFor PET Imaging in CNS Lymphoma Patients - \[90Y\]Y-PTT Endoradiotherapy in CNS Lymphoma Patients - \[CREMA\]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma - 19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers - A Case Study of Nivolumab for Relapsed/Refractory Primary Central Nervous System Lymphoma - A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL - A Dose-escalating Pilot Study of Orelabrutinib for Newly-diagnosed PCNSL - A Multicenter, Prospective Clinical Trial With a Concurrent Control Evaluating Methotrexate Combined With Rituximab,Sintilimab and Pirtobrutinib vs. Investigator-Selected Standard of Care in Treatment-Naive PCNSL - A Nomogram for Predicting the Diagnosis of Central Malignant Tumors Based on Preoperative Clinical Characteristics and Laboratory Indicators: - A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas - A Phase I/II Study to Investigate the Use of VORAXAZE™ As Intended Intervention in Patients with CNSL - a Phase II Study in Primary Central Nervous System Lymphoma - A Phase II Trail of Chidamide ,Rituximab and Methotrexate in Lymphoma Patients - A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas - A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes - A Prospective Clinical Study of BTK Inhibitor, PD-1 and Formustine in the First-line Treatment of Primary Central Nervous System Lymphoma - A Safety Study of Rituximab Plus MTX Injected Into the Cerebrospinal Fluid in the Treatment of Brain Lymphoma - A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL) - A Study of F520 in Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) or Secondary Central Nervous System Lymphoma (SCNSL) ### Drugs in development (25) - Acalabrutinib Phase 2 - Bimiralisib Phase 2 - Camrelizumab Phase 2 - Cytarabine Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 1 - [Filgrastim](https://trialight.com/data/asset/filgrastim-942bf0d3-0bf1-4bf8-9e38-81a6c277d728.md) Phase 2 - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) Phase 2 - Idarubicin Phase 2 - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) Phase 2 - Lisocabtagene maraleucel Phase 2 - Loncastuximab Phase 1 - [Methotrexate](https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d.md) Phase 3 - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) Phase 2 - [Obinutuzumab](https://trialight.com/data/asset/obinutuzumab-1aa4994f-1407-4a89-93f0-0b3aa295ad6e.md) Phase 2 - [Orelabrutinib](https://trialight.com/data/asset/orelabrutinib-f8934fae-2fe2-4ce8-a944-a872e27bfa47.md) Phase 3 - [Pembrolizumab](https://trialight.com/data/asset/pembrolizumab-f9ac1934-47a5-4a53-ae55-20b7d53d8815.md) Phase 2 - [Pemetrexed](https://trialight.com/data/asset/pemetrexed-2221859e-676b-4d76-97df-e11f3f9664a1.md) Phase 2 - Penpulimab Phase 2 - [Rituximab](https://trialight.com/data/asset/rituximab-3fb73477-f618-414e-aa0a-9ccba4d6da3f.md) Phase 3 - [Temozolomide](https://trialight.com/data/asset/temozolomide-3fac1b09-bcc5-4875-871e-2cc6460dc731.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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