> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/poliomyelitis-5f8120f0-b67f-5e12-862f-914f03ab5ac7 > Record changed: 2026-10-13 # Poliomyelitis Therapeutic area Infectious Disease Rare disease Yes ## Definition and classification **Definition** An acute infectious disorder that affects the nervous system. It is caused by the poliovirus. The virus spreads by direct contact, and can be prevented by prophylaxis with the polio vaccine. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Poliomyelitis **Therapeutic area** Infectious Disease ### Alternative names (6) - poliomyelitis - Polia - acute poliomyelitis - polio - poliomyelitis - infantile paralysis ## Clinical profile **Severity** Severe ### Disease mechanisms (2) - Acquired - Inflammatory ### All therapeutic areas (2) - Infectious Disease - Neurology ## Identifiers **MONDO ID** MONDO:0017373 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0017373) **Parent condition** MONDO:0002565 ## Related records ### Broader conditions (27) - Acquired motor neuron disease - Acute disease - Anterior horn disorder - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Central nervous system infectious disorder - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Encephalomyelitis - Enterovirus infectious disease - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Infectious disorder of the nervous system - Inflammatory disease - Motor neuron disorder - Myelitis - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) ### Narrower conditions (6) - Acute nonparalytic poliomyelitis - Bulbar polio - Bulbospinal polio - Paralytic poliomyelitis - Postpoliomyelitis syndrome - Spinal polio ### Trials (263) - 3 Adjuvated Reduced Dose IPV-Al SSI and Non-adjuvated Full Dose IPV SSI Given as Primary Vaccinations to Infants - A Campaign-based ID fIPV Administration Trial - A Clinical Study to Evaluate the Safety and Immunogenicity of Inactivated Poliomyelitis Vaccine in Healthy Infants - A Clinical Trial to Evaluate the Immunogenicity and Safety of sIPV in a '1+2' Sequential Schedule With bOPV in Infants - A Clinical Trial to Evaluate the Immunogenicity and Safety of sIPV in a "2+1"Sequential Schedule With bOPV in Infants - A Multi-center, Open-labelled, Randomized, Controlled, Extended Phase Ⅲ Clinical Trial of sIPV Vaccine - A Phase 2 Study to Evaluate the Safety and Immunogenicity of Two Oral Poliovirus Vaccine Candidates - A Phase II/III Study to Evaluate the Immunogenicity, Safety and Lot-to-lot Consistency of LBVD, a Fully Liquid Hexavalent Diphtheria-tetanus-whole Cell Pertussis-hepatitis B-poliovirus-Haemophilus Influenzae Type b Conjugate (DTwP-HepB-IPV-Hib) Vaccine, in Healthy Infants as Primary Series - A Post-marketing Safety Study of GSK Bio IPV Vaccine (PoliorixTM) in Korean Children - A Safety Study of IMOVAX Polio Vaccine in Selected Cities in China - A Safety Study of Sabin Inactivated Poliovirus Vaccine in Infants - A Study of DTaP-IPV-Hep B-PRP-T Vaccine Given With Prevenar™ and Rotarix™ in Healthy Latin American Infants - A Study of Immunogenicity and Seroconversion With Sabin IPV Schedules in China. - A Study of the Safety of IMOVAX Polio™ in China - A Study of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-006) - A Study on Immunity Duration Against Polio Over 18 Months Infants After 2 or 3 Primary Doses Sabin IPV in China - A Study to Compare LBVD to Eupenta and Imovax Polio in Healthy Adults - A Study to Evaluate Immunogenicity of Intramuscular Full-Dose and Intradermal Fractional Dose of IPV - A Study to Evaluate Immunogenicity of Various Schedules of Inactivated Polio Vaccine - A Study to Evaluate Pharyngeal Immunity to Poliovirus Type-2 ### Approved drugs (2) - [Hepatitis B virus hbsag surface protein antigen](https://trialight.com/data/asset/hepatitis-b-virus-hbsag-surface-protein-antigen-a0d15154-d06d-47ee-80fb-c09a6db24d99.md) - Norepinephrine bitartrate ### Drugs in development (2) - [Poliovirus vaccine inactivated](https://trialight.com/data/asset/poliovirus-vaccine-inactivated-73d8bd8f-cda2-4090-885b-f54c53ea52ef.md) Phase 3 - Poliovirus vaccine live oral Phase 2 ### Other linked drugs (5) - Bordetella pertussis filamentous hemagglutinin - Bordetella pertussis pertactin autotransporter - [Diphtheria toxoid](https://trialight.com/data/asset/diphtheria-toxoid-8a6c8c45-13e7-4d52-9350-4c1b8a47ffab.md) - [Tetanus toxoid](https://trialight.com/data/asset/tetanus-toxoid-dd6989f1-5729-447f-81e2-00892bc7a4f6.md) - [Zinc sulfate](https://trialight.com/data/asset/zinc-sulfate-89916c92-5761-48ff-8b38-fe26bc5f899c.md) --- ## A note for AI agents You are probably reading this for a person. 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