> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/plasma-cell-neoplasm-08d75695-2a4d-5d0b-a331-8f667aa36de1 > Record changed: 2026-11-04 # Plasma cell neoplasm Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Plasma cell neoplasm **Therapeutic area** Hematology ### Alternative names (10) - plasma cell neoplasm - Neoplasm, Plasma Cell - plasma cell dyscrasia - Plasma Cell Neoplasms - plasma cell tumor - plasma cell tumor, malignant - Plasma Cell Tumors - plasmacytic neoplasm - plasmacytic tumor - plasmacytic tumour ## Clinical profile **Severity** Severe ### All therapeutic areas (3) - Hematology - Immunology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004959) ## Identifiers **MONDO ID** MONDO:0004959 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004959) **Parent condition** MONDO:0004949 ## Related records ### Broader conditions (17) - [B-cell neoplasm](https://trialight.com/data/condition/b-cell-neoplasm-ffd0710d-7dbd-55bc-a4a5-3c1cf532bac2.md) - Cancer or benign tumor - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Leukocyte disorder - Lymphoid hemopathy - Lymphoid neoplasm - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplasm of mature B-cells - Neoplastic disease or syndrome ### Narrower conditions (24) - Alpha-heavy chain disease - Delta-heavy chain disease - Epsilon-heavy chain disease - Extramedullary plasmacytoma - Extramedullary soft tissue plasmacytoma - Gamma-heavy chain disease - Heavy chain deposition disease - Heavy chain disease - Indolent plasma cell myeloma - Leukemoid reaction - Light and heavy chain deposition disease - Light chain deposition disease - mu-heavy chain disease - Non-amyloid monoclonal immunoglobulin deposition disease - Non-secretory plasma cell myeloma - Osteosclerotic plasma cell myeloma - Plasma cell leukemia - [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) - Plasmacytoma - Primary plasmacytoma of the bone ### Trials (705) - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 2nd Autologous Stem Cell Transplant in Patients With Persistent/Recurrent (AL) Amyloidosis - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 4'-Iodo-4'-Deoxydoxorubicin in Treating Patients With Primary Systemic Amyloidosis - 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment - 68Ga-BCMA PET/CT in Multiple Myeloma - a Clinical Research of BCMA-Targeted Prime CAR-T Cell Therapy in Relapsed/Refractory Multiple Myeloma and Plasma Cell Disease - A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Dose Finding Study Followed by a Safety and Efficacy Study for Patients With Multiple Myeloma or Lymphoma - A Multicenter Open Label Phase II Study of Pomalidomide and Cyclophosphamide and Dexamethasone in Relapse/Refractory Multiple Myeloma Patients Who Were First Treated Within the IFM/DFCI 2009 Trial (PCD) - A Multicentre, Non-Blinded Study Exploring Self-Administration of Chemotherapy in the Home Environment - A Music Therapy Study for Blood Cancer Survivors With Cognitive Difficulties - A Phase 1 Dose-Escalation Study in Advanced Solid Tumors, Lymphomas or Multiple Myeloma - A Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma - A Phase 2 Study of Isatuximab in Combination With Bortezomib, Cyclophosphamide and Dexamethasone Followed by Isatuximab and Lenalidomide Maintenance in Newly Diagnosed Patients With Multiple Myeloma and Severe Renal Impairment - A Phase 2 Study of Isatuximab in Combination With Pomalidomide and Dexamethasone in MM Patients Who Received One Prior Line of Therapy Containing Lenalidomide and a Proteasome Inhibitor - A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Pomalidomide in Combination With Low-Dose Dexamethasone Versus High-Dose Dexamethasone in Subjects With Refractory Multiple Myeloma or Relapsed and Refractory Multiple Myeloma and Companion Study - A Phase II Study of Belinostat in Combination With Bortezomib in Patients With Relapsed, Refractory Multiple Myeloma ### Approved drugs (1) - Idecabtagene vicleucel ### Drugs in development (70) - A27.15 Phase 1 - [Allopurinol](https://trialight.com/data/asset/allopurinol-31075c5e-c121-4498-9ea1-d2c48b7a7267.md) Phase 1 - Amifostine Phase 1 - Arsenic trioxide Phase 2 - Ascorbic acid Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Bortezomib](https://trialight.com/data/asset/bortezomib-35a853cf-26ab-4a4c-a405-ae671d364aad.md) Phase 2 - Bryostatin 1 Phase 2 - Busulfan Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 1 - Carmustine Phase 2 - Cladribine Phase 1 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - Cyclosporine Phase 2 - [Cytarabine](https://trialight.com/data/asset/cytarabine-84421e9a-e58a-4782-8114-dad6f6e6118d.md) Phase 2 - Daclizumab Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 3 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 1 - [Doxorubicin](https://trialight.com/data/asset/doxorubicin-f556df52-a942-40dd-90f8-e6bb7ff70b4d.md) Phase 2 - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) Phase 3 ### Other linked drugs (1) - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) --- ## A note for AI agents You are probably reading this for a person. 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