> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5 > Record changed: 2026-10-13 # Plasma cell myeloma Therapeutic area Immunology Rare disease Yes ## Definition and classification **Definition** A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001) **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Plasma cell myeloma **Therapeutic area** Immunology ### Alternative names (17) - plasma cell myeloma - Kahler disease - Kahler's disease - Multiple Myeloma - medullary plasmacytoma - multiple myeloma - multiple myeloma, resistance to, Somatic mutation - multiple myeloma, susceptibility to, Somatic mutation - multiple myeloma/plasma cell myeloma - myeloid neoplasm of plasma cell - myeloma - myeloma, multiple - myeloma, plasma cell, malignant - myelomatosis - plasma cell myeloid neoplasm - plasma cell myeloma - myeloma - multiple ## Clinical profile **Severity** Severe ### All therapeutic areas (3) - Hematology - Immunology - Oncology ## Identifiers **MONDO ID** MONDO:0009693 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009693) **Parent condition** MONDO:0000621 ## Related records ### Broader conditions (21) - [B-cell neoplasm](https://trialight.com/data/condition/b-cell-neoplasm-ffd0710d-7dbd-55bc-a4a5-3c1cf532bac2.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - Immune system cancer - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Leukocyte disorder - Lymphoid hemopathy - Lymphoid neoplasm - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) - Myeloid neoplasm - Neoplasm - Neoplasm of mature B-cells - Neoplastic disease or syndrome ### Narrower conditions (4) - Indolent plasma cell myeloma - Non-secretory plasma cell myeloma - Osteosclerotic plasma cell myeloma - Smoldering plasma cell myeloma ### Trials (3,795) - "FU-IFM2009" Database Post IFM/DFCI 2009 Study - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - "Pseudo-scanner" MRI Sequences for the Detection of Bone Lesions in Multiple Myeloma - "WB-DCE-MRI" in Multiple Myeloma as an Independent Prognostic Factor for Disease-free Survival - 1068GCC Evaluate Efficacy & Explore Mechanism of Acupuncture in Treating Bortezomib-induced Peripheral Neuropathy (BIPN) in Multiple Myeloma - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 1454GCC: Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma - 18F-Fluciclovine PET/CT in Multiple Myeloma - 2-Methoxyestradiol in Treating Patients With Advanced Solid Tumors - 2006-32 Phase II Study of Rapidly Recycled High Dose DTPACE - 2015-09: a Phase II Randomized, Open-label Study of Anti-signaling Lymphocytic Activation Molecule Monoclonal Antibody During Maintenance Therapy - 2015-10: Expanded Natural Killer Cells and Elotuzumab for High-Risk Myeloma Post- Autologous Stem Cell Transplant (ASCT) - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma - ²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma - 2nd Autologous Stem Cell Transplant in Patients With Persistent/Recurrent (AL) Amyloidosis - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 4'-Iodo-4'-Deoxydoxorubicin in Treating Patients With Primary Systemic Amyloidosis - 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment - 5p15/ 9q22/ 15q22 Hyperdiploidy and Their Significance in Multiple Myeloma Patients ### Approved drugs (29) - Belantamab mafodotin - Bortezomib D-mannitol - [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) - Carmustine - Ciltacabtagene autoleucel - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) - Dexamethasone acetate - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) - Elotuzumab - [Elranatamab](https://trialight.com/data/asset/elranatamab-43094116-a114-45cf-88c8-60ef9865def2.md) - Idecabtagene vicleucel - Interferon alfa-2B - [Isatuximab](https://trialight.com/data/asset/isatuximab-a4041fba-ee04-4ad4-a6fc-39e24da4aedb.md) - Ixazomib citrate - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) - Lenalidomide hydrochloride monohydrate - Melphalan - Melphalan flufenamide hydrochloride - Melphalan hydrochloride ### Drugs in development (451) - [(R)-melphalan](https://trialight.com/data/asset/r-melphalan-7fbc2fe5-ce39-43af-8972-4e0d27151445.md) Phase 3 - 2-methoxyestradiol Phase 2 - 6-O-benzylguanine Phase 2 - A27.15 Phase 1 - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 2 - ABBV-467 Phase 1 - ABC-294640 Phase 1 - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Phase 1 - Acalabrutinib Phase 1 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 3 - Actinium AC 225 dotatate Phase 1 - Adavosertib Phase 2 - AEW-541 Phase 1 - Afatinib Phase 2 - Afatinib dimaleate Phase 2 - [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Phase 2 - Afuresertib Phase 1 - Aldesleukin Phase 2 - Alemtuzumab Phase 1 - Alethine Phase 1 ### Other linked drugs (8) - [Bortezomib](https://trialight.com/data/asset/bortezomib-35a853cf-26ab-4a4c-a405-ae671d364aad.md) - Cerivastatin - Dacinostat - Futibatinib - Lisocabtagene maraleucel - Tagraxofusp - Trapidil - Zoxazolamine --- ## A note for AI agents You are probably reading this for a person. 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