> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/pai-syndrome-ca62b972-11f1-54a6-a99d-6da0b4c1edc1
> Record changed: 2026-10-13

# Pai syndrome

Therapeutic area

Rheumatology

Rare disease

Yes

## Definition and classification

**Definition**

Pai syndrome is an idiopathic developmental disorder characterized by median cleft of the upper lip (MCL), midline polyps of the facial skin and nasal mucosa, and pericallosal lipomas. Hypertelorism with ocular anomalies are also observed, generally with normal neuropsychological development.

**Genetic basis**

Yes

**Non-human condition**

No

**Rare disease**

Yes

**Listing at source**

Listed

**Condition name**

Pai syndrome

**Therapeutic area**

Rheumatology

### Alternative names (4)

- Pai syndrome
- Pai syndrome
- median cleft of the upper lip-corpus callosum lipoma-cutaneous polyps syndrome
- median cleft of upper lip with polyps of facial skin and nasal mucosa

## Clinical profile

**All therapeutic areas**

- Rheumatology

**Severity**

Mild

### Disease mechanisms (3)

- Developmental
- Genetic
- Hereditary

## Identifiers

**MONDO ID**

MONDO:0007956

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007956)

**Parent condition**

MONDO:0016643

## Related records

### Broader conditions (14)

- Bone development disease
- [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md)
- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Disorder of development or morphogenesis
- Dysostosis
- Frontonasal dysplasia
- Hereditary disease
- Human disease
- Musculoskeletal system disorder
- Skeletal system disorder

### Trials (1)

- [Y-6 Sublingual Tablets for Acute Penetrating Artery Infarction](https://trialight.com/data/trial/y-6-sublingual-tablets-for-acute-penetrating-artery-8d79ed5e-7a5a-41e3-a68c-02f083a6a0f9.md)

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