> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/otitis-media-aa1c6944-b9f6-58dc-8e64-6624ba1f0d76 > Record changed: 2026-11-04 # Otitis media Therapeutic area Otology/Audiology Rare disease No ## Definition and classification **Definition** Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Otitis media **Therapeutic area** Otology/Audiology ### Alternative names (5) - otitis media - inflammation of middle ear - medial otitis - middle Ear Inflammation - otitis media (disease) ## Clinical profile **Disease mechanisms** - Inflammatory Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005441) **All therapeutic areas** - Otology/Audiology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005441) **Severity** Mild ## Identifiers **MONDO ID** MONDO:0005441 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005441) **Parent condition** MONDO:0003276 ## Related records ### Broader conditions (9) - Auditory system disorder - Disease - Disease by body system or component - Disease by developmental or physiological process - Disorder of ear - Human disease - Inflammatory disease - Middle ear disorder - Otorhinolaryngologic disease ### Narrower conditions (27) - Acute allergic mucoid otitis media - Acute allergic sanguinous otitis media - Acute allergic serous otitis media - Acute eustachian salpingitis - Acute sanguinous otitis media - Acute serous otitis media - Acute transudative otitis media - Acute tympanitis - Allergic otitis media - Blue drum syndrome - Chronic atticoantral disease - Chronic eustachian salpingitis - Chronic non-suppurative otitis media - Chronic otitis media - Chronic purulent otitis media - Chronic tubotympanic suppurative otitis media - Chronic tympanitis - [Infectious otitis media](https://trialight.com/data/condition/infectious-otitis-media-f40bd52c-06fc-5246-993c-86e35f6a6c07.md) - Middle ear cholesterol granuloma - Non-suppurative otitis media ### Trials (228) - A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea - A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media - A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media - A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea - A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes - A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children - A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections - A Study of the Effectiness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of Infection and Inflammation of the Middle Ear That is Difficult to Treat - A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months - A Study to Compare the Immunogenicity of GSK Biologicals' 10Pn-PD-DiT 4-dose Presentation to the Licensed 1-dose Synflorix™ (10Pn-PD-DiT) Vaccine When Co-administered With DTPw-combination Vaccine in Healthy Infants - A Trial of Point of Care Information in Ambulatory Pediatrics - A Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media - Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections - Acclarent Tympanostomy Tube Delivery System for the Treatment of Patients Requiring Tympanostomy Tube Insertion - Acetic Acid Ear Drops Versus 0.3 % Ciprofloxacin for Chronic Suppurative Otitis Media. - Acute Otitis Media (AOM) Therapy Trial in Young Children - Acute Otitis Media: Adjuvant Therapy to Improve Outcome - Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy - Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT) - Amoxicillin Clavulanate in Treatment of Acute Otitis Media ### Approved drugs (26) - [Amoxicillin](https://trialight.com/data/asset/amoxicillin-09050e6a-69b4-42d1-b3eb-79212edcf388.md) - Azithromycin - Azithromycin monohydrate - Boric acid - Cefaclor - Cefdinir - Cefixime - Cefpodoxime proxetil - Cefprozil, (E)- - Ceftibuten dihydrate - Ceftriaxone sodium - Cefuroxime axetil - Cephalexin - Clarithromycin - Clavulanate potassium - Garenoxacin mesylate - Lascufloxacin - Morniflumate - Sitafloxacin - [Streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae CRM197](https://trialight.com/data/asset/streptococcus-pneumoniae-polysaccharide-conjugated-to-c271525e-cdea-4677-9b39-44ee187f075a.md) ### Drugs in development (12) - [Ciprofloxacin](https://trialight.com/data/asset/ciprofloxacin-8dbb4fad-883a-4e58-8501-5887c084b0ef.md) Phase 3 - [Clavulanic acid](https://trialight.com/data/asset/clavulanic-acid-465f3e04-3ad5-4ece-97cf-d63cae081959.md) Phase 3 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 3 - Faropenem medoxomil Phase 2 - Finafloxacin Phase 2 - [Levofloxacin](https://trialight.com/data/asset/levofloxacin-091d90d2-35bb-4b1e-b685-02b522e966f5.md) Phase 3 - Ofloxacin Phase 3 - Pazufloxacin Phase 1 - Piperacillin Phase 1 - Simethicone Phase 2 - Tazobactam Phase 1 - Telithromycin Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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