> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/osteosarcoma-d6ad580f-c521-585b-9a22-26006b6bff2b > Record changed: 2026-10-13 # Osteosarcoma Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Osteosarcoma **Therapeutic area** Oncology ### Alternative names (8) - osteosarcoma - bone tissue neoplasm - osteogenic sarcoma - osteoid sarcoma - osteosarcoma - osteosarcoma (disease) - osteosarcoma, malignant - sarcoma of osteoid ## Clinical profile **All therapeutic areas** - Oncology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0009807 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009807) **Parent condition** MONDO:0005089 ## Related records ### Broader conditions (8) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Disease - Disease by etiologic mechanism - Human disease - Neoplasm - Neoplastic disease or syndrome - [Sarcoma](https://trialight.com/data/condition/sarcoma-96102668-50d9-5d69-b154-719396a38dc1.md) ### Narrower conditions (28) - Adult extraskeletal osteosarcoma - Asynchronous multifocal osteogenic sarcoma - Bone osteosarcoma - Breast extraskeletal osteosarcoma - Central nervous system extraskeletal osteosarcoma - Childhood extraosseous osteosarcoma - Childhood intracortical osteosarcoma - Childhood parosteal osteosarcoma - Chondroblastic osteosarcoma - Conventional osteosarcoma - Extraosseous osteosarcoma - Fibrosarcomatous osteosarcoma - High grade surface osteosarcoma - Juxtacortical osteosarcoma - Kidney osteogenic sarcoma - Liver extraskeletal osteosarcoma - Localized osteosarcoma - Low grade central osteosarcoma - Mediastinal extraskeletal osteosarcoma - Metachronous osteosarcoma of the bone ### Trials (471) - 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Advanced Epithelial Cancer, Malignant Lymphoma, or Sarcoma - 18F-FTC-146 PET/CT in Newly-Diagnosed Osteosarcoma - 3D Printed Implants for the Defect Reconstruction in Patients With Chest Wall Tumors - 68Ga-B7-H3 Nanobody ImmunoPET in Osteosarcoma - A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy - A Clinical Study of PD-L1 Antibody ZKAB001(Drug Code) in Limited Stage of High-grade Osteosarcoma - A Clinical Study of Surufatinib Combined With Chemotherapy as Neoadjuvant Treatment in Osteosarcoma - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors - A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Bone and Soft Tissue Tumors - A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy - A Eurosarc Study of Mifamurtide in Advanced Osteosarcoma (MEMOS) - A Look Back at How Well Interventional Treatments Work for Bronchopleural Fistulas in Patients With Lung Metastases From Osteosarcoma - A Phase 2 Pilot Study to Evaluate the Safety and the Anti-Tumour Activity of the Myc Inhibitor OMO-103 Administered Intravenously in Patients With Advanced High-Grade Osteosarcoma - A Phase I Clinical Trial of Neoadjuvant Chemotherapy With/Without SPIONs/SMF for Patients With Osteosarcoma - A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma - A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors - A Phase I Study of OncoLAR® (Registered Trademark) (NSC 685403) With/Without Tamoxifen in Patients With Osteosarcoma - A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors - A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors - A Phase I Trial Of The Humanized Anti-GD2 Antibody In Children And Adolescents With Neuroblastoma, Osteosarcoma, Ewing Sarcoma and Melanoma ### Approved drugs (5) - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) - [Leucovorin calcium](https://trialight.com/data/asset/leucovorin-calcium-8da292ca-1b92-4365-b525-77d897b1c096.md) - [Levoleucovorin](https://trialight.com/data/asset/levoleucovorin-fdff57d9-ad4f-4a44-ad7d-40932f268d1b.md) - [Levoleucovorin calcium](https://trialight.com/data/asset/levoleucovorin-calcium-21e918a4-89ff-4c55-aafc-3b4fd0086bc6.md) - Mifamurtide ### Drugs in development (82) - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Phase 1 - Anti-GD2 monoclonal antibody 3F8 Phase 1 - Arfolitixorin Phase 1 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 2 - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Phase 2 - [Azacitidine](https://trialight.com/data/asset/azacitidine-4f3798ea-680c-4288-a367-118b7bfe411f.md) Phase 1 - [Azenosertib](https://trialight.com/data/asset/azenosertib-944931bf-2ff3-48e7-8c82-2d2dde814b6e.md) Phase 1 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Cabozantinib](https://trialight.com/data/asset/cabozantinib-e69f9fa7-bbbc-4e52-b0df-6073598de2a7.md) Phase 2 - Cabozantinib S-malate Phase 2 - Camrelizumab Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - CC-115 Phase 1 - Ceralasertib Phase 2 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 3 - Cixutumumab Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 2 - [Denosumab](https://trialight.com/data/asset/denosumab-9ee8731d-42aa-4d04-abbd-9dffa084523f.md) Phase 2 - Dexrazoxane Phase 1 - Dinutuximab Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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