> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/osteoarthritis-e8c428fb-1597-576d-bcf0-f3b27ebc6a00 > Record changed: 2026-10-13 # Osteoarthritis Therapeutic area Rheumatology Rare disease No ## Definition and classification **Definition** A noninflammatory degenerative joint disease occurring chiefly in older persons, characterized by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Osteoarthritis **Therapeutic area** Rheumatology ### Alternative names (2) - osteoarthritis - degenerative joint disease ## Clinical profile **Disease mechanisms** - Inflammatory **All therapeutic areas** - Rheumatology **Severity** Mild ## Identifiers **MONDO ID** MONDO:0005178 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005178) **Parent condition** MONDO:0005578 ## Related records ### Broader conditions (11) - [Arthritic joint disease](https://trialight.com/data/condition/arthritic-joint-disease-594ede40-773b-5c20-afc1-eb18dabbe039.md) - [Arthropathy](https://trialight.com/data/condition/arthropathy-bbc05db6-678e-5b8c-abde-9076b91012cc.md) - [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md) - Bone inflammation disease - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - Inflammatory disease - Musculoskeletal system disorder - Skeletal system disorder ### Narrower conditions (5) - Osteoarthritis, hand - Osteoarthritis, hip - [Osteoarthritis, knee](https://trialight.com/data/condition/osteoarthritis-knee-217c801b-d59c-514b-92dd-3abbf23b24d7.md) - Osteoarthritis, spine - Osteoarthritis, toe ### Trials (2,677) - "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis" - "Blind" vs. Fluoroscopy-Guided Steroid Injections for Knee Osteoarthritis - "Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis" - "Ready-to-use" Intra-articular Formulation of Mesenchymal Stromal Cells - "Score Infectivity" During Reoperation on Total Hip or Knee Prosthesis - "Transarterial Microembolization (TAME) in Inflammatory Knee Pathology" - "Translating Articular Biomarkers Into Diagnoses" - 10003 PRO Current Products - 12-Week No-Rofecoxib Plus Aspirin Endoscopy Study (0782-003) - 14022 ATTUNE Cementless RP Clinical Performance Evaluation - 15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis - 2 Weekly Intra-articular Hyaluronan Knee Injections, Given 1 wk. Apart, of HYMOVIS Combined With Physical Exercise Program (PEP) Compared to PEP Alone, in Relatively Young, Active Population of Subjects With Patellofemoral Osteoarthritis (PFOA) and/or Tibiofemoral Osteoarthritis (TFOA) - 2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use - 26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle - 28mm Ceramic-on-Ceramic Total Hip Replacement Study - 2ccPA Study in Patients With Symptomatic Knee Osteoarthritis - 3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis - 3VM for Treatment of Chronic Osteoarthritis Knee Pain - 52 Week, International, Multi-center, Randomized, Double-blind, Double-dummy, Parallel-group Clinical Trial to Compare Retention on Treatment, Safety, Tolerability & Efficacy of Lumiracoxib 100 mg od, Lumiracoxib 100 mg Bid & Celecoxib 200 mg od in Pts With Primary OA of Hip, Knee, Hand or Spine - 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee ### Approved drugs (39) - Aceclofenac - Amlodipine besylate - Capsaicin - [Celecoxib](https://trialight.com/data/asset/celecoxib-d2adc66b-f8fb-471f-8779-d55e35cdd52c.md) - Cortisone acetate - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) - Dexamethasone sodium phosphate - [Diclofenac](https://trialight.com/data/asset/diclofenac-6bb6f2bf-7068-41cb-8e1d-c1c073cf27b3.md) - Diclofenac potassium - Diclofenac sodium - Diflunisal - Esomeprazole magnesium - Etodolac - [Famotidine](https://trialight.com/data/asset/famotidine-5721dbb9-1373-4622-a660-e27ebf480acc.md) - Fenoprofen calcium - Hydrocortisone - Ibuprofen - Indomethacin - Ketoprofen - Lidocaine ### Drugs in development (122) - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 3 - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) Phase 3 - AGG-523 Phase 1 - Aldumastat Phase 2 - Alendronic acid Phase 2 - Allopurinol Phase 1 - AMG-108 Phase 2 - Amobarbital Phase 1 - [Anakinra](https://trialight.com/data/asset/anakinra-2c0352ee-cb20-46c5-bd87-6350d9024e75.md) Phase 2 - ARRY-797 Phase 2 - Ascorbic acid Phase 1 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - ATB-346 Phase 2 - Autologous adipose-derived stromal vascular fraction Phase 1 - Betamethasone acetate Phase 3 - Betamethasone sodium phosphate Phase 3 - BI113823 Phase 1 - BMS-986142 Phase 1 - Bupivacaine Phase 3 - [Buprenorphine](https://trialight.com/data/asset/buprenorphine-c075c804-b1a4-4839-84d9-79aa0e258585.md) Phase 3 ### Other linked drugs (11) - Choline magnesium trisalicylate - Curcuminoids - Diphenhydramine - Esflurbiprofen - Flurbiprofen - Hylan G-F 20 - Isoxicam - [Metformin hydrochloride](https://trialight.com/data/asset/metformin-hydrochloride-10ef84a6-9052-459a-9134-fada726e38d0.md) - [Nepafenac](https://trialight.com/data/asset/nepafenac-96b6dc32-9431-4662-97dd-bbaf8ea3d7a7.md) - Proglumetacin - Proquazone --- ## A note for AI agents You are probably reading this for a person. 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