> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/opiate-dependence-75d4615b-1445-5bca-8b05-ae8266043d82
> Record changed: 2026-11-04

# Opiate dependence

Rare disease

No

## Definition and classification

**Definition**

Disorders related or resulting from abuse or mis-use of opioids.

**Genetic basis**

No

**Non-human condition**

No

**Rare disease**

No

**Listing at source**

Listed

**Condition name**

Opiate dependence

### Alternative names (4)

- opiate dependence
- opioid dependence
- Opioid Dependence, on Agonist Therapy
- opioid type dependence

## Clinical profile

**Severity**

Mild

## Identifiers

**MONDO ID**

MONDO:0005530

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005530)

**Parent condition**

MONDO:0005303

## Related records

### Broader conditions (7)

- Disease
- Disease by developmental or physiological process
- Drug dependence
- Human disease
- [Psychiatric disorder](https://trialight.com/data/condition/psychiatric-disorder-26a422d1-1076-53d2-9858-6cb1cac40a21.md)
- Substance dependence
- Substance-related disorder

### Narrower conditions (2)

- Heroin dependence
- Morphine dependence

### Trials (1,550)

- A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence
- A Bridge to Treatment: The Therapeutic Workplace and Methadone Treatment
- A Brief Negotiation Interview Chatbot to Improve Buprenorphine Engagement Among Justice-Involved Individuals
- A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment
- A Bundled Intervention
- A Bundled Intervention to End Opioid Overdoses
- A Chatbot To Support Substance Use Recovery
- A Clinical Study To Characterize The Pharmacokinetics And The Effects Of Food On Oxycodone In Healthy Volunteers
- A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use
- A Clinical Trial of Telehealth Treatment for Opioid Use Disorders
- A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
- A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults
- A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults
- A Comparison of PR Oxycodone/Naloxone and PR Oxycodone After Cardiac Surgery
- A Consensus on Opioid Prescription for Oncologic Patients in Latin America - A DELPHI Study.
- A Digital Intervention to Prevent Initiation of Opioid Misuse in Adolescents in School-based Health Centers
- A Digital Intervention to Prevent the Initiation of Opioid Misuse in Adolescents in School-based Health Centers
- A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment
- A Laboratory Model for Heroin Abuse Medications - 8
- A Mobile Executive Functioning Intervention for Momentary Craving in Opioid Use Disorders

### Approved drugs (9)

- [Buprenorphine](https://trialight.com/data/asset/buprenorphine-c075c804-b1a4-4839-84d9-79aa0e258585.md)
- Buprenorphine hydrochloride
- Levomethadyl acetate
- Levomethadyl acetate hydrochloride
- Methadone hydrochloride
- Methadyl acetate
- Methylnaltrexone bromide
- Naloxegol oxalate
- Naloxone hydrochloride dihydrate

### Drugs in development (97)

- \[11C\]-carfentanil Phase 1
- Aprepitant Phase 1
- [Atomoxetine](https://trialight.com/data/asset/atomoxetine-1775a289-8363-4e6f-be94-6b2bd2db4995.md) Phase 2
- Buspirone Phase 2
- Calcitriol Phase 1
- [Cannabidiol](https://trialight.com/data/asset/cannabidiol-e1ac1a9a-1111-460c-8a8f-5216571adce8.md) Phase 2
- Cannabinol Phase 2
- Citalopram Phase 2
- Clonidine Phase 2
- Cocaine Phase 2
- Cycloserine Phase 2
- Darunavir Phase 1
- Dexmedetomidine Phase 3
- Dextroamphetamine Phase 2
- Dextroamphetamine adipate Phase 2
- Dextroamphetamine sulfate Phase 2
- Dextromethorphan Phase 3
- Dextromethorphan polistirex Phase 3
- Diacetylmorphine Phase 3
- Disulfiram Phase 2

### Other linked drugs (3)

- Isoniazid
- Nicotine
- Rifapentine

---

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