> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/open-angle-glaucoma-fb887921-4122-599b-b8a0-928b40ddc7a2 > Record changed: 2026-10-13 # Open-angle glaucoma Therapeutic area Ophthalmology Rare disease No ## Definition and classification **Definition** Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Open-angle glaucoma **Therapeutic area** Ophthalmology ### Alternative names (6) - open-angle glaucoma - POAG - glaucoma, primary open angle - open angle glaucoma - pigmentary glaucoma - primary open angle glaucoma ## Clinical profile **All therapeutic areas** - Ophthalmology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0005338 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005338) **Parent condition** MONDO:0005041 ## Related records ### Broader conditions (7) - Disease - Disease by body system or component - Disorder of orbital region - Disorder of visual system - Eye disorder - [Glaucoma](https://trialight.com/data/condition/glaucoma-7a3c05c0-9871-55db-af74-962761181784.md) - Human disease ### Narrower conditions (13) - Glaucoma 1, open angle, A - Glaucoma 1, open angle, J - Glaucoma 1, open angle, K - Glaucoma 1, open angle, l - Glaucoma 1, open angle, M - Glaucoma 1, open angle, N - Glaucoma 1, open angle, O - Glaucoma 1, open angle, P - Glaucoma type 1C - Juvenile open angle glaucoma - Low tension glaucoma - OPTN-related open angle glaucoma - Residual stage of open angle glaucoma ### Trials (917) - \[KJ-TFC-005\] Phase 3 Study, Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension - 18 Month Prospective Efficacy and Safety Study of Bimatoprost Intracameral Implant (DURYSTA) - 180 Degree vs. 360 Degree Selective Laser Trabeculoplasty as Initial Therapy for Glaucoma - 24 Hour IOP Lowering Efficacy of AL-3789 - 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients - 24-hour Efficacy and Tolerability of the Tafluprost-timolol Fixed Association Without Preservatives in Glaucomatous or Ocular Hypertensive Patients Already Treated With Latanoprost Preserved With BAK. A Prospective, Open Study of 3 Months Duration. - 24-hour Efficacy of AR-12286 - 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients - 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination - 24-hour IOP-lowering Effect of Brimonidine 0.1% - 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations - 24-hour Wear Performance and Safety Study of Smartlens miLens Contact Lens for IOP Monitoring - 24-hr Intraocular Pressure Control With Dorzolamide/Timolol vs the Brimonidine/Timolol Fixed Combination - 24h Continuous Intraocular Pressure (IOP) Monitoring vs Goldmann Applanation Tonometry - 5-Year Postoperative Outcomes of Patients Who Completed the CREST Study - A 12 Week Comparison of DuoTrav and Xalacom in Open-Angle Glaucoma - A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension - A 12-week, Randomized, Double-masked, Parallel Group Comparison of Evening Dosing With Xalacom in Subjects With Glaucoma - A 12-Week, Randomized, Double-Masked, Parallel Group Comparison Of Evening Dosing With Xalacom In Subjects With Glaucoma - A 12week, Randomized, Evaluator-Masked, Parallel Group Comparing Evening Dosing Of Xalacom Vs Cosopt In Subj W/ Glaucoma ### Approved drugs (17) - Betaxolol hydrochloride - [Bimatoprost](https://trialight.com/data/asset/bimatoprost-6eef0f4d-2227-4a51-94e0-7508a5f1c01b.md) - Brimonidine tartrate - Brinzolamide - Carteolol hydrochloride - Dapiprazole hydrochloride - Dorzolamide hydrochloride - [Latanoprost](https://trialight.com/data/asset/latanoprost-70b1bf55-247c-476b-a7ee-5a056ee0cddd.md) - Latanoprostene bunod - Methazolamide - Netarsudil dimesylate - Omidenepag isopropyl - Pilocarpine - Tafluprost - Timolol - [Timolol maleate](https://trialight.com/data/asset/timolol-maleate-d3b5d7ee-d8f2-4ddd-9168-1f49a7b9f34b.md) - Travoprost ### Drugs in development (21) - Anecortave acetate Phase 2 - Betaxolol Phase 3 - Bimatoprost grenod Phase 2 - Brimonidine Phase 2 - [Citicoline](https://trialight.com/data/asset/citicoline-f5938bef-5da4-4d58-8885-c4ba9dd1cf3c.md) Phase 3 - DE-104 Phase 2 - Dorzolamide Phase 3 - Evodenoson Phase 1 - [Fluorouracil](https://trialight.com/data/asset/fluorouracil-f8444d73-5c73-4f35-aa71-67d578277450.md) Phase 3 - Ginkgo Phase 2 - Memantine Phase 3 - Mitomycin Phase 2 - [Netarsudil](https://trialight.com/data/asset/netarsudil-cdf69483-92c3-4ac8-b941-7366b7bf529a.md) Early phase 1 - Niacinamide Phase 2 - Ofloxacin Phase 3 - [Prednisolone](https://trialight.com/data/asset/prednisolone-783fce19-b285-4835-90c3-3db5a6364414.md) Phase 3 - Pyruvate Phase 2 - [Ranibizumab](https://trialight.com/data/asset/ranibizumab-2ca53f2a-3d69-417e-a84c-3f9e436c1913.md) Phase 1 - [Sodium chloride](https://trialight.com/data/asset/sodium-chloride-a67c33bc-45ef-42e4-8022-d121f0a86585.md) Phase 2 - Trabodenoson Phase 3 ### Other linked drugs (4) - Demecarium bromide - Levobunolol - Metformin - Metipranolol --- ## A note for AI agents You are probably reading this for a person. 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