> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/norum-disease-ec6b7dc1-624f-5fca-8b8d-d365fc1f9214 > Record changed: 2026-11-04 # Norum disease Therapeutic area Metabolic Disease Rare disease Yes ## Definition and classification **Definition** A form of lecithin-cholesterol acyltransferase deficiency (LCAT) characterized clinically by corneal opacities, hemolytic anemia, and renal failure, and biochemically by severely decreased HDL cholesterol and complete deficiency of the LCAT enzyme. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Norum disease **Therapeutic area** Metabolic Disease ### Alternative names (5) - Norum disease - complete LCAT deficiency - FLD - lecithin acyltransferase deficiency - lecithin:cholesterol acyltransferase deficiency ## Clinical profile **All therapeutic areas** - Metabolic Disease Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009515) **Severity** Severe ### Disease mechanisms (3) - Genetic - Hereditary - Inborn Error of Metabolism Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009515) ## Identifiers **MONDO ID** MONDO:0009515 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009515) **Parent condition** MONDO:0001822 ## Related records ### Broader conditions (12) - Disease - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - [Hereditary disease](https://trialight.com/data/condition/hereditary-disease-df2f8f05-e0c9-5777-8e51-c3b6639743d3.md) - Human disease - Hypoalphalipoproteinemia - Hypolipoproteinemia - Inborn errors of metabolism - [Inherited lipid metabolism disorder](https://trialight.com/data/condition/inherited-lipid-metabolism-disorder-37fa2264-1fbc-5478-9987-67169bc5aaae.md) - LCAT deficiency - [Metabolic disease](https://trialight.com/data/condition/metabolic-disease-3d73c19d-b8c8-5be8-add5-77c7d794dacd.md) ### Trials (62) - A Bioequivalence Study Comparing Methylprednisolone Suspension to Methylprednisolone Tablets Under Fed Conditions - A Comparative Bioavailability Study of Lisinopril Tablets, 40 mg - Effect of Food Study - A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers - A Study to Compare the Relative Bioavailability of Two Iberdomide (CC-220) Formulations and to Assess The Effect Of Food on the Drug Levels of Iberdomide in Healthy Adult Participants - A Study to Demonstrate Bioequivalence Between a 12-mg Dose of an Oral Suspension Formulation of Perampanel and a 12-mg Tablet Formulation of Perampanel Under Fasted and Fed Conditions in Healthy Subjects - A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants. - AStudy to Evaluate the Bioavailability of PF 04965842 in Healthy Subjects - Bioavailability Study of (Buspar) Buspirone HCl Tablets Under Fasting and Fed Conditions - Bioavailability Study of Ciprofloxacin 1000 mg ER Tablets of Dr. Reddy's Under Non-Fasting Conditions - Bioavailability Study of Desloratadine 5 mg Tablet of Dr. Reddy's Under Fed Conditions - Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting and Fed Conditions - Bioavailability Study of Leflunomide Tablets Under Fed Conditions - Bioavailability Study of Metronidazole Capsules Under Fed Conditions - Bioavailability Study of Ondansetron Orally Disintegrating Tablets Under Fed Conditions - Bioavailability Study of Propranolol Under Fed Conditions - Bioavailability Study of Torsemide Tablets Under Fed Conditions - Bioavailability Study of Tramadol/APAP Tablets Under Fed Conditions - Bioequivalence Study of Amlodipine Besylate/Benazepril HCl 10 mg/40 mg Capsules of Dr. Reddy's Under Fed Conditions - Bioequivalence Study of Bisoprolol Fumarate Tablet 10 mg Under Fed Condition - Bioequivalence Study of Cabergoline Tablets and Dostinex Under Fed Conditions ### Other linked drugs (1) - Cholesterol --- ## A note for AI agents You are probably reading this for a person. 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