> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646 > Record changed: 2026-10-13 # Non-Hodgkin lymphoma Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Non-Hodgkin lymphoma **Therapeutic area** Hematology ### Alternative names (6) - non-Hodgkin lymphoma - NHL - non-Hodgkin lymphoma - non-Hodgkin's lymphoma - non-Hodgkin's lymphoma (NHL) - non-Hodgkins lymphoma ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Hematology - Oncology ## Identifiers **MONDO ID** MONDO:0018908 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0018908) **Parent condition** MONDO:0005062 ## Related records ### Broader conditions (13) - Cancer or benign tumor - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - Lymphoid hemopathy - Lymphoid neoplasm - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) - Neoplasm - Neoplastic disease or syndrome ### Narrower conditions (159) - A53 diffuse large B-cell lymphoma - Acute biphenotypic leukemia - Acute lymphoblastic leukemia - Adult acute lymphoblastic leukemia - Adult T-cell leukemia/lymphoma - Aggressive B-cell non-Hodgkin lymphoma - Aggressive NK-cell leukemia - ALK-negative anaplastic large cell lymphoma - ALK-positive anaplastic large cell lymphoma - ALK-positive large B-cell lymphoma - Anaplastic large cell lymphoma - [Angioimmunoblastic T-cell lymphoma](https://trialight.com/data/condition/angioimmunoblastic-t-cell-lymphoma-5b697108-b9cf-53e9-afde-71a36bf55d6b.md) - B acute lymphoblastic leukemia with DUX4 rearrangement - B acute lymphoblastic leukemia with PAX5 P80R mutation - B-cell acute lymphoblastic leukemia - B-cell acute lymphoblastic leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) - B-cell adult acute lymphocytic leukemia - B-cell childhood acute lymphoblastic leukemia - [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) - [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) ### Trials (1,135) - 'Re-Priming' RT After Incomplete Response to CAR-T in R/R NHL - (TAA)-Specific Cytotoxic T-Lymphocytes to Pediatric Patients With Lymphomas (pediTACTAL). - 124I-FIAU Imaging in EBV and KSHV Associated Cancers - 1630GCC: Zydelig Maintenance in B-Cell Non-Hodgkin's Lymphoma After Autologous Stem Cell Transplantation - 18F-F-AraG PET Imaging to Evaluate Immunological Response to CAR T Cell Therapy in Lymphoma - 3rd Party LMP1/2-Specific Cytotoxic T Lymphocytes for EBV-Associated Lymphoma - 9-ING-41 in Patients With Advanced Cancers - A Bioequivalence Study of Vinorelbine Tartrate Injectable Emulsion in Patients With Advanced Cancer. - A Clinical Study Exploring the Safety, Efficacy and Metabolic Kinetics of CT1182 Injection in Patients With Relapsed / Refractory Non Hodgkin Lymphoma - A Clinical Study of CHT101 in CD70-Positive Relapsed or Refractory Hematological Malignancies - A Clinical Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Abexinostat in Chinese Patients - A Clinical Trial in Adults With Non-Hodgkin Lymphoma (NHL), With a Particular Emphasis on Cutaneous T Cell Lymphoma (CTCL), Testing the Safety and Activity of a Novel Drug to Inhibit a Protein Called Tumor Necrosis Factor Receptor 2 That Drives Both Lymphoma Growth and Escape of the Immune System - A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae - A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) - A Comparative Study for Non-Hodgkin's Lymphoma in Hepatitis B Virus Carriers - A Dose and Schedule Finding Trial With AMG 531 for Chemotherapy Induced Thrombocytopenia (CIT) in Adults With Lymphoma - A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer - A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma - A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies - A First in Human Study of AUR 103 Calcium to Evaluate Safety, Pharmacokinetics and Pharmacodynamics ### Approved drugs (11) - Bendamustine hydrochloride - [Brentuximab vedotin](https://trialight.com/data/asset/brentuximab-vedotin-b112eac4-7573-41dc-af6c-6c9212132a79.md) - Carmustine - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) - Idelalisib - Melphalan hydrochloride - [Methotrexate](https://trialight.com/data/asset/methotrexate-aa7ef9da-5b6e-44a1-942c-610e3de14a1d.md) - Methotrexate sodium - Pixantrone dimaleate - Plerixafor - [Rituximab](https://trialight.com/data/asset/rituximab-3fb73477-f618-414e-aa0a-9ccba4d6da3f.md) ### Drugs in development (293) - [1018 ISS](https://trialight.com/data/asset/1018-iss-911ee104-bf1a-4263-a7e1-743a42d4d654.md) Phase 2 - AB-101 Phase 1 - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Phase 1 - Abexinostat Phase 1 - ABT-510 Phase 2 - Acalabrutinib Phase 2 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 2 - ADG-106 Phase 1 - [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Phase 1 - AFM-11 Phase 1 - AG-24322 Phase 1 - Agatolimod sodium Phase 2 - Aldesleukin Phase 2 - Alemtuzumab Phase 1 - Allopurinol Phase 3 - Amifostine Phase 2 - [Amoxicillin](https://trialight.com/data/asset/amoxicillin-09050e6a-69b4-42d1-b3eb-79212edcf388.md) Phase 3 - ANTI-TAC 90 Y-HAT Phase 1 - Antineoplaston A10 Phase 2 - [Apilimod mesylate](https://trialight.com/data/asset/apilimod-mesylate-2a01ca48-f560-4231-b26b-aa9fb9f4dd3e.md) Phase 2 ### Other linked drugs (10) - Azercabtagene zapreleucel - Cerdulatinib - Febarbamate - Iodine - Nadravaleucel - Nimesulide - Orvacabtagene autoleucel - Pirtobrutinib - Trofosfamide - Yttrium Y 90 epratuzumab --- ## A note for AI agents You are probably reading this for a person. 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