> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/neuroendocrine-carcinoma-66cf52f3-045d-597f-80d3-d7a422d5ef1c > Record changed: 2026-10-13 # Neuroendocrine carcinoma Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Neuroendocrine carcinoma **Therapeutic area** Oncology ### Alternative names (4) - neuroendocrine carcinoma - NEC - neuroendocrine cancer - neuroendocrine carcinoma ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Endocrinology - Oncology ## Identifiers **MONDO ID** MONDO:0002120 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0002120) **Parent condition** MONDO:0004993 ## Related records ### Broader conditions (14) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Endocrine gland neoplasm - [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md) - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Human disease - Malignant endocrine neoplasm - Neoplasm - Neoplastic disease or syndrome - [Neuroendocrine neoplasm](https://trialight.com/data/condition/neuroendocrine-neoplasm-ab85715e-e4fa-5698-91d9-024cf0bab33c.md) ### Narrower conditions (47) - Ampulla of vater small cell neuroendocrine carcinoma - Anal canal neuroendocrine neoplasm - Bartholin gland small cell carcinoma - Breast large cell neuroendocrine carcinoma - Cervical large cell neuroendocrine carcinoma - Cervical small cell carcinoma - Colon small cell neuroendocrine carcinoma - Combined lung carcinoma - Combined small cell lung carcinoma - [Cutaneous neuroendocrine carcinoma](https://trialight.com/data/condition/cutaneous-neuroendocrine-carcinoma-ba38e774-613b-5117-ab12-d3c4e4cf6ad8.md) - Endometrial small cell carcinoma - Esophageal small cell neuroendocrine carcinoma - Extrahepatic bile duct small cell adenocarcinoma - Familial medullary thyroid carcinoma - Gallbladder small cell neuroendocrine carcinoma - Gastric small cell neuroendocrine carcinoma - Goblet cell carcinoma - Hypercalcemic type ovarian small cell carcinoma - Large cell neuroendocrine carcinoma - Laryngeal small cell carcinoma ### Trials (165) - 3-arm Trial to Evaluate Pasireotide LAR/Everolimus Alone/in Combination in Patients With Lung/Thymus NET - LUNA Trial - 5FU and Octreotide Long-acting Release (LAR) for Neuroendocrine Tumors - 68Ga-DOTATATE PET Scan Imaging in Patients With Neuroendocrine Tumors - 68Ga-DOTATATE PET Scan in Neuroendocrine Cancer - 68Ga-DOTATATE PET-CT for Diagnosis of Neuroendocrine Tumors (NETs) - A Clinical Study to Assess the Combination of Two Drugs (177Lu-DOTATATE and Nivolumab) in Neuroendocrine Tumours - A Clinical Trial of LBL-024 Combined With Etoposide and Platinum in Patients With Advanced Neuroendocrine Carcinoma - A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs (SPECTRAL-1) - A First-in-Human Phase I Trial With Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors, Carcinomas and Malignant Peripheral Nerve Sheath Tumors - A Irinotecan Liposome Trial of in Advanced Neuroendocrine Carcinoma - A Phase 3 Study to Evaluate Surufatinib Plus Toripalimab in the Treatment of Advanced Neuroendocrine Carcinoma - A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HLX3901 in Patients With Advanced SCLC or NEC - A Phase I Study of Belinostat in Combination With Cisplatin and Etoposide in Adults With Small Cell Lung Carcinoma and Other Advanced Cancers - [A Phase I Study of HS-20108 in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-i-study-of-hs-20108-in-participants-with-advanced-817dd0d6-3bbd-4f97-9924-dcd0558cd796.md) - A Phase II Clinical Study of SHR-A1904 Monotherapy in Second-Line or Later Treatment of Advanced Neuroendocrine Carcinoma - A Phase II Clinical Trial to Evaluate Safety and Efficacy of XmAb20717 in Advanced Rare Cancers - A Single-arm Trial of Atezolizumab/Platinum/Etoposide for the Treatment of Advanced Large-cell Neuroendocrine Cancer of the Lung - A Single-arm, Open-label, Clinical Trial of Surufatinib/Serplulimab/Platinum/Etoposide in Neuroendocrine Carcinoma. - A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001) - A Study of 177Lu-DTPA-SC16.56 in People With Neuroendocrine Carcinomas of the Lung and Prostate ### Drugs in development (59) - .ALPHA.-pyrrolidinononanophenone Phase 1 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 2 - Atiprimod Phase 2 - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Cabozantinib](https://trialight.com/data/asset/cabozantinib-e69f9fa7-bbbc-4e52-b0df-6073598de2a7.md) Phase 2 - Cabozantinib S-malate Phase 2 - Camrelizumab Phase 2 - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) Phase 2 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 2 - Copper oxodotreotide CU-64 Phase 2 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 2 - Dordaviprone Phase 2 - Dotamtate Phase 1 - Dotamtate PB-212 Phase 1 - [Durvalumab](https://trialight.com/data/asset/durvalumab-bca7c265-7862-46e1-bf29-3dd2fdda4954.md) Phase 2 - Edotreotide Phase 2 - Etoposide Phase 2 ### Other linked drugs (4) - Edotreotide gallium GA-68 - Iobenguane I 123 - [Retifanlimab](https://trialight.com/data/asset/retifanlimab-57767872-c97a-4714-befa-fa3aa2ae5ce8.md) - 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