> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7 > Record changed: 2026-10-13 # Neurodegenerative disease Therapeutic area Neurology Rare disease No ## Definition and classification **Definition** A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Neurodegenerative disease **Therapeutic area** Neurology ### Alternative names (7) - neurodegenerative disease - degenerative disease - brain degeneration - central nervous system degenerative disorder - central nervous system neurodegenerative disorder - degenerative disorder of central nervous system - cerebral degeneration disease ## Clinical profile **All therapeutic areas** - Neurology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0005559 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005559) **Parent condition** MONDO:0002602 ## Related records ### Broader conditions (5) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Disease - Disease by body system or component - Human disease - Nervous system disorder ### Narrower conditions (920) - AARS1-related leukoencephalopathy - ABeta amyloidosis, Arctic type - ABeta amyloidosis, dutch type - ABeta amyloidosis, Iowa type - ABeta amyloidosis, Italian type - ABetaA21G amyloidosis - ABetaL34V amyloidosis - Abetalipoproteinemia - ABri amyloidosis - Aceruloplasminemia - ACO2-related optic atrophy with or without extraocular features - Acquired human prion disease - Acquired motor neuron disease - Acute disseminated encephalomyelitis - Acute disseminated encephalomyelitis with anti-MOG antibodies - Acute disseminated encephalomyelitis without anti-MOG antibodies - Acute hemorrhagic leukoencephalitis - Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome - Acute nonparalytic poliomyelitis - Acute transverse myelitis with anti-MOG antibodies ### Trials (442) - \[18F\]MC225-PET in Neurodegenerative Disease - \[18F\]NIDF PET Imaging in Tau-related Diseases - \[18F\]THK-5351 Positron Emission Computed Tomography Study of Normal, Mild Cognitive Impairment, Alzheimer's Disease and Other Neurodegenerative Disease - A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease - A Biomarker Study of ATH434 in Participants With MSA - A Biomarker-chip Assay in Preserved Red Blood Cells for the Diagnosis of Alzheimer's Disease - A Bridging Study on Efficacy and Safety of \[18F\]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese Population - A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831 - A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b) - A FIH Study to Assess the Safety and Tolerability of NS Intravenous NS101 Infusion - A First in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of ONO-2808-01 in Healthy Participants - A First Time in Human Study of SNP318 as a Treatment for Neurodegenerative Diseases Including Alzheimer's Disease - A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease - A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects - A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers - A Low-Cost Balance Training Platform Using Augmented Reality in Neurorehabilitation: a Usability Study - A Multicenter Observational Study to Evaluate the Effectiveness of Patisiran in Patients With Polyneuropathy of ATTRv Amyloidosis With a V122I or T60A Mutation - A Multicenter Prospective Registry for the Management of Degenerative Spine Disorders - A New 3D Virtual Reality-based Upper Limb Training to Improve Dexterity in Parkinson's Disease - A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease ### Approved drugs (2) - Amifampridine phosphate - Flortaucipir F 18 ### Drugs in development (22) - ANX-005 Phase 1 - Buntanetap Phase 1 - Buntanetap tartrate Phase 1 - Ceperognastat Phase 1 - Dalzanemdor Phase 1 - Dextromethorphan Phase 2 - Etazolate Phase 2 - Flurimedrimer (18F) Phase 1 - Fosmetpantotenate Phase 3 - Ismidenon Phase 1 - Latozinemab Phase 3 - Levacetylleucine Phase 1 - Niacinamide Phase 2 - Pegipanermin Phase 1 - Peptide T Phase 2 - Pimavanserin Phase 3 - Posatirelin Phase 3 - Taurursodiol Phase 1 - Tertomotide Phase 1 - Tilavonemab Phase 1 ### Other linked drugs (7) - Amifampridine - [Citicoline](https://trialight.com/data/asset/citicoline-f5938bef-5da4-4d58-8885-c4ba9dd1cf3c.md) - Dopamine - Emapunil - Memantine - NNZ-2591 - Pyrimidine --- ## A note for AI agents You are probably reading this for a person. 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