> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/nephrotic-syndrome-c47dd11b-4c29-5968-aab7-a1f91392b5ac > Record changed: 2026-11-04 # Nephrotic syndrome Therapeutic area Nephrology Rare disease No ## Definition and classification **Definition** A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Nephrotic syndrome **Therapeutic area** Nephrology ### Alternative names (4) - nephrotic syndrome - nephrotic syndromes - syndrome, nephrotic - syndromes, nephrotic ## Clinical profile **Disease mechanisms** - Syndromic Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005377) **All therapeutic areas** - Nephrology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005377) **Severity** Severe ## Identifiers **MONDO ID** MONDO:0005377 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005377) **Parent condition** MONDO:0002254 ## Related records ### Broader conditions (7) - Disease - Disease by body system or component - Human disease - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) - Nephrosis - Syndromic disease - [Urinary system disorder](https://trialight.com/data/condition/urinary-system-disorder-68e8d758-aac9-544b-8378-87fe59b2c7b0.md) ### Narrower conditions (48) - Congenital nephrotic syndrome, Finnish type - Familial idiopathic steroid-resistant nephrotic syndrome - Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation - Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis - Familial idiopathic steroid-resistant nephrotic syndrome with minimal changes - Familial nephrotic syndrome - Familial steroid-resistant nephrotic syndrome with sensorineural deafness - Focal segmental glomerulosclerosis 1 - Idiopathic multidrug-resistant nephrotic syndrome - Idiopathic nephrotic syndrome - Idiopathic steroid-resistant nephrotic syndrome with sensitivity to second-line immunosuppressive therapy - Idiopathic steroid-sensitive nephrotic syndrome - Idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation - Idiopathic steroid-sensitive nephrotic syndrome with focal segmental hyalinosis - Idiopathic steroid-sensitive nephrotic syndrome with minimal change - Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance - Immunoglobulin-mediated membranoproliferative glomerulonephritis - LAMB2-related infantile-onset nephrotic syndrome - Nephrotic syndrome 14 - Nephrotic syndrome 15 ### Trials (196) - A Phase 1 Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ManNAc in Subjects With Primary Podocyte Diseases - A Phase II, Repeat Dose, Proof of Mechanism Study of Losmapimod to Reduce Proteinuria in Patients With Focal Segmental Glomerulosclerosis (FSGS) - A Pilot Study to Assess the Efficacy of Rituximab Therapy in Treatment Resistant FSGS - A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS) - A Prospective Multi-dose Study of Apixaban in Subjects With Nephrotic Syndrome - A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines - A Study of Anti-CD38 Monoclonal Antibody (SG301) Subcutaneous Injection in Children With Nephrotic Syndrome With Frequent Relapses or Steroid Dependence - A Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis (FSGS) - A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome - A Study to Evaluate the Efficacy and Safety of Mizoribine in the Treatment of Refractory Nephrotic Syndrome - A Study to Evaluate the Efficacy and Safety of Obinutuzumab Versus MMF in Participants With Childhood Onset Idiopathic Nephrotic Syndrome - Acthar for Treatment of Proteinuria in Diabetic Nephropathy Patients - Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients - ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children - Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy - Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome - Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) - Allogeneic CD19/BCMA CAR-T for B Cell-Related Autoimmune Disease - Amiloride in Nephrotic Syndrome - An Outcome Analysis of Primary Membranous Nephropathy ### Approved drugs (20) - Albumin human - Betamethasone acetate - Bumetanide - Chlorothiazide - Chlorothiazide sodium - Chlorthalidone - [Cholestyramine](https://trialight.com/data/asset/cholestyramine-02403ab6-2c23-416a-ba64-dd03a00539a1.md) - Cortisone acetate - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) - Dexamethasone sodium phosphate - Ethacrynic acid - Furosemide - Hydrochlorothiazide - Methylprednisolone acetate - [Prednisolone](https://trialight.com/data/asset/prednisolone-783fce19-b285-4835-90c3-3db5a6364414.md) - Prednisolone sodium phosphate - [Prednisone](https://trialight.com/data/asset/prednisone-a5a99f90-5fbe-45c2-a625-34ba78735da6.md) - Spironolactone - Triamterene ### Drugs in development (34) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 2 - Acloproxalap Phase 2 - Aldesleukin Phase 2 - [Alirocumab](https://trialight.com/data/asset/alirocumab-94bb5dc8-32f2-4ed6-a82e-b554472e2cd5.md) Phase 2 - Amiloride Phase 3 - [Apixaban](https://trialight.com/data/asset/apixaban-9e91f03a-6eac-4da8-9f08-88d740399be5.md) Phase 1 - Atorvastatin Phase 2 - Azithromycin Phase 1 - Azithromycin monohydrate Phase 1 - [Belimumab](https://trialight.com/data/asset/belimumab-a26501e5-b55d-4ccb-a721-a60267831e12.md) Phase 2 - Corticotropin Phase 3 - Dalteparin sodium Phase 1 - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) Phase 2 - [Dupilumab](https://trialight.com/data/asset/dupilumab-7930d513-66cb-4433-906b-2d2f5fc01f1e.md) Phase 2 - [Enoxaparin sodium](https://trialight.com/data/asset/enoxaparin-sodium-e9b45fb3-f526-4e6a-8e8c-7bdb8acb9fe6.md) Phase 2 - Felzartamab Phase 2 - Ilacirnon Phase 2 - Levamisole hydrochloride Phase 3 - [Methylprednisolone](https://trialight.com/data/asset/methylprednisolone-f881999e-4ad3-485a-8fbe-6e7b979365f9.md) Phase 3 - Mizoribine Phase 3 ### Other linked drugs (9) - Betamethasone - Betamethasone sodium phosphate - Edoxaban - Galactose - [Hydrocortisone](https://trialight.com/data/asset/hydrocortisone-2a0db2d4-4a67-4db0-851f-091bd6b99fdb.md) - [Montelukast](https://trialight.com/data/asset/montelukast-dccca6f4-f8a6-4dee-91d2-4bad3d856226.md) - [Triamcinolone](https://trialight.com/data/asset/triamcinolone-c53cf39c-0a06-4666-8b46-0c99745c9c4b.md) - Zinc acetate - Zinc sulfate --- ## A note for AI agents You are probably reading this for a person. 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