> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/myeloproliferative-neoplasm-b03c8629-79c9-5884-9030-7d16d2b538e4 > Record changed: 2026-10-29 # Myeloproliferative neoplasm Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008) **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Myeloproliferative neoplasm **Therapeutic area** Hematology ### Alternative names (14) - myeloproliferative neoplasm - CMPD - MPD - MPN - chronic myeloproliferative disease - chronic myeloproliferative disorder - chronic myeloproliferative neoplasm - myeloproliferative disorder - myeloproliferative neoplasm - myeloproliferative neoplasm, chronic - myeloproliferative tumor - myeloproliferative tumour - chronic myeloproliferative disorders - myeloproliferative neoplasms ## Clinical profile **Severity** Severe ### All therapeutic areas (4) - Hematology - Immunology - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0020076 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0020076) **Parent condition** MONDO:0005170 ## Related records ### Broader conditions (26) - Bone cancer - [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md) - Bone marrow cancer - Bone marrow disorder - Bone marrow neoplasm - Bone neoplasm - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Connective tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - Immune system cancer - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Musculoskeletal system cancer ### Narrower conditions (139) - [Acquired polycythemia vera](https://trialight.com/data/condition/acquired-polycythemia-vera-5c3132a8-49a0-5b93-b3d6-cd5f1fa9e10e.md) - Acute basophilic leukemia - Acute biphenotypic leukemia - Acute erythroid leukemia - Acute leukemia of ambiguous lineage - Acute megakaryoblastic leukemia - Acute megakaryoblastic leukemia in adult - Acute megakaryoblastic leukemia in down syndrome - Acute megakaryoblastic leukemia without down syndrome - Acute monocytic leukemia - Acute myeloblastic leukemia with maturation - Acute myeloblastic leukemia without maturation - [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) - Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent - Acute myeloid leukemia and myelodysplastic syndromes related to radiation - Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor - Acute myeloid leukemia by FAB classification - Acute myeloid leukemia with 11q23 abnormalities - Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) - Acute myeloid leukemia with BCR-ABL1 ### Trials (357) - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis - 2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment - A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors - A New Blood Score for Myelofibrosis Staging - A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms - A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT - A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation - A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm - A Phase I Trial of ZIO-101 in Hematologic Cancers - A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms - A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation - A Pragmatic Clinical Trial to Prevent Relapse for Myeloid Malignancies With Measurable Disease Prior to Allogeneic Transplant - A Prospective Patient Reported Outcomes and Wearables Study in Myeloproliferative Neoplasms - A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) - A Standardized Nursing Intervention Protocol for HCT Patients - A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm - A Study of Anagrelide Controlled Release (GALE-401) in Patients With High Platelet Counts Due to Bone Marrow Disorders ### Drugs in development (43) - A27.15 Phase 1 - Aldesleukin Phase 2 - Alemtuzumab Phase 2 - Amifostine Phase 1 - Amphotericin B Phase 3 - Busulfan Phase 2 - Camidanlumab tesirine Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - Cilengitide Phase 1 - Cladribine Phase 1 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - Cyclosporine Phase 1 - Cytarabine Phase 3 - Decitabine Phase 3 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 1 - E2.3 Phase 1 - Edodekin alfa Phase 1 - Etoposide Phase 3 - Fenretinide Phase 1 - [Filgrastim](https://trialight.com/data/asset/filgrastim-942bf0d3-0bf1-4bf8-9e38-81a6c277d728.md) Phase 3 ### Other linked drugs (2) - Pelabresib - Tagraxofusp --- ## A note for AI agents You are probably reading this for a person. 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