Myeloproliferative neoplasm
Therapeutic area
Hematology
Rare disease
Yes
- Definition
- A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Myeloproliferative neoplasm
- Therapeutic area
- Hematology
- myeloproliferative neoplasm
- CMPD
- MPD
- MPN
- chronic myeloproliferative disease
- chronic myeloproliferative disorder
- chronic myeloproliferative neoplasm
- myeloproliferative disorder
- myeloproliferative neoplasm
- myeloproliferative neoplasm, chronic
- myeloproliferative tumor
- myeloproliferative tumour
- chronic myeloproliferative disorders
- myeloproliferative neoplasms
- Severity
- Severe
- Hematology
- Immunology
- Oncology
- Rheumatology
- MONDO ID
- MONDO:0020076
- Parent condition
- MONDO:0005170
Related records
Broader conditions (26)
- Bone cancer
- Bone disorder
- Bone marrow cancer
- Bone marrow disorder
- Bone marrow neoplasm
- Bone neoplasm
- Cancer
- Cancer or benign tumor
- Connective tissue disorder
- Connective tissue neoplasm
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
- Hematopoietic and lymphoid system neoplasm
- Human disease
- Immune system cancer
- Immune system disorder
- Musculoskeletal system cancer
Narrower conditions (139)
- Acquired polycythemia vera
- Acute basophilic leukemia
- Acute biphenotypic leukemia
- Acute erythroid leukemia
- Acute leukemia of ambiguous lineage
- Acute megakaryoblastic leukemia
- Acute megakaryoblastic leukemia in adult
- Acute megakaryoblastic leukemia in down syndrome
- Acute megakaryoblastic leukemia without down syndrome
- Acute monocytic leukemia
- Acute myeloblastic leukemia with maturation
- Acute myeloblastic leukemia without maturation
- Acute myeloid leukemia
- Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
- Acute myeloid leukemia and myelodysplastic syndromes related to radiation
- Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
- Acute myeloid leukemia by FAB classification
- Acute myeloid leukemia with 11q23 abnormalities
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
- Acute myeloid leukemia with BCR-ABL1
Trials (357)
- 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder
- 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis
- 2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II
- 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
- 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment
- A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors
- A New Blood Score for Myelofibrosis Staging
- A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms
- A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT
- A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation
- A Phase 2 Study Evaluating Olutasidenib in Combination With Hypomethylating Agents in Patients With IDH1-mutated Higher-risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Advanced Myeloproliferative Neoplasm
- A Phase I Trial of ZIO-101 in Hematologic Cancers
- A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
- A Pragmatic Clinical Trial to Prevent Relapse for Myeloid Malignancies With Measurable Disease Prior to Allogeneic Transplant
- A Prospective Patient Reported Outcomes and Wearables Study in Myeloproliferative Neoplasms
- A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)
- A Standardized Nursing Intervention Protocol for HCT Patients
- A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm
- A Study of Anagrelide Controlled Release (GALE-401) in Patients With High Platelet Counts Due to Bone Marrow Disorders
Drugs in development (43)
- A27.15 Phase 1
- Aldesleukin Phase 2
- Alemtuzumab Phase 2
- Amifostine Phase 1
- Amphotericin B Phase 3
- Busulfan Phase 2
- Camidanlumab tesirine Phase 2
- Carboplatin Phase 2
- Cilengitide Phase 1
- Cladribine Phase 1
- Cyclophosphamide Phase 3
- Cyclosporine Phase 1
- Cytarabine Phase 3
- Decitabine Phase 3
- Docetaxel Phase 1
- E2.3 Phase 1
- Edodekin alfa Phase 1
- Etoposide Phase 3
- Fenretinide Phase 1
- Filgrastim Phase 3
Other linked drugs (2)
- Pelabresib
- Tagraxofusp