Myeloid leukemia
Therapeutic area
Hematology
Rare disease
No
- Definition
- A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- No
- Listing at source
- Listed
- Condition name
- Myeloid leukemia
- Therapeutic area
- Hematology
- myeloid leukemia
- leukaemia granulocytic
- leukaemia myeloid
- leukemia granulocytic
- leukemia myelogenous
- leukemia myeloid
- leukemia, granulocytic, malignant
- myelocytic leukaemia
- myelocytic leukemia
- myelogenous leukaemia
- myelogenous leukemia
- myeloid leukemia
- non-lymphoblastic leukaemia
- non-lymphoblastic leukemia
- non-lymphocytic leukaemia
- non-lymphocytic leukemia
- Severity
- Severe
- Hematology
- Immunology
- Oncology
- Rheumatology
- MONDO ID
- MONDO:0004643
- Parent condition
- MONDO:0005059
Related records
Broader conditions (28)
- Bone cancer
- Bone disorder
- Bone marrow cancer
- Bone marrow disorder
- Bone marrow neoplasm
- Bone neoplasm
- Cancer
- Cancer or benign tumor
- Connective tissue disorder
- Connective tissue neoplasm
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Hematologic disorder
- Hematopoietic and lymphoid cell neoplasm
- Hematopoietic and lymphoid system neoplasm
- Human disease
- Immune system cancer
- Immune system disorder
- Leukemia
Narrower conditions (118)
- Acute basophilic leukemia
- Acute biphenotypic leukemia
- Acute erythroid leukemia
- Acute leukemia of ambiguous lineage
- Acute megakaryoblastic leukemia
- Acute megakaryoblastic leukemia in adult
- Acute megakaryoblastic leukemia in down syndrome
- Acute megakaryoblastic leukemia without down syndrome
- Acute monocytic leukemia
- Acute myeloblastic leukemia with maturation
- Acute myeloblastic leukemia without maturation
- Acute myeloid leukemia
- Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
- Acute myeloid leukemia and myelodysplastic syndromes related to radiation
- Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
- Acute myeloid leukemia by FAB classification
- Acute myeloid leukemia with 11q23 abnormalities
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
- Acute myeloid leukemia with BCR-ABL1
- Acute myeloid leukemia with CBFA2T3-GLIS2 fusion
Trials (144)
- (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
- A Clinical Trail of Demethylation Drug Combined With Chemotherapy in Intermediate-risk AML
- A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
- A Multicentre, Retrospective Study to Evaluate the Outcome of HSCT Mismatch Unrelated Donors
- A Notch Signalling Pathway Inhibitor for Patients With T-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL)(0752-013)
- A Phase 2 Study of ABT-199 in Subjects With Acute Myelogenous Leukemia (AML)
- A Phase I Study of 5-Azacytidine in Combination With Chemotherapy for Children With Relapsed or Refractory ALL or AML
- A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia
- A Phase II Study of Flumatinib Versus Imatinib to Treat Philadelphia Chromosome Positive Chronic Myelogenous Leukemia
- A Safety, Tolerability and Preliminary Efficacy Study of CC-90011 in Combination With Venetoclax and Azacitidine in R/R Acute Myeloid Leukemia and Treatment-naïve Participants Not Eligible for Intensive Therapy
- A Study Comparing Ponatinib and Nilotinib in Participants With Chronic Myeloid Leukemia
- A Study Evaluating Venetoclax in Combination With Low-Dose Cytarabine in Treatment-Naïve Participants With Acute Myelogenous Leukemia
- A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome
- A Study of HMPL-306 in Patients With IDH1 and/or IDH2 Mutation of Relapsed/Refractory Myeloid Leukemia/Neoplasms
- A Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)
- A Study of Lenalidomide in Pediatric Subjects With Relapsed or Refractory Acute Myeloid Leukemia
- A Study of ONO-7475 in Patients With Acute Leukemias
- A Study Of Panobinostat In Children With Refractory Hematologic Malignancies
- A Study of Ponatinib in Japanese Participants With Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL)
- A Study of the Safety and Pharmacokinetics of RO6839921, An MDM2 Antagonist, in Patients With Advanced Cancers, Including Acute Myeloid Leukemia.
Approved drugs (6)
- Bosutinib monohydrate
- Decitabine
- Gemtuzumab ozogamicin
- Gilteritinib fumarate
- Ponatinib hydrochloride
- Quizartinib dihydrochloride
Drugs in development (43)
- AMG-319 Phase 1
- AMG-900 Phase 1
- AVE-9633 Phase 1
- Azacitidine Phase 3
- Azenosertib Phase 1
- Barasertib Phase 1
- Busulfan Phase 1
- CC-401 Phase 1
- Cedazuridine Phase 1
- Cirtuvivint Phase 1
- Cladribine Phase 2
- Cyclophosphamide Phase 1
- Cytarabine Phase 3
- Cytarabine hydrochloride Phase 1
- Dasatinib anhydrous Phase 1
- Daunorubicin Phase 3
- Eltanexor Phase 1
- Enasidenib Phase 2
- Enasidenib mesylate Phase 2
- Etoposide phosphate Phase 1
Other linked drugs (2)
- Bosutinib
- Ponatinib