> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/myelodysplastic-myeloproliferative-neoplasm-1fce813e-4882-5c37-a9f8-567d47f0e521 > Record changed: 2026-10-13 # Myelodysplastic/myeloproliferative neoplasm Therapeutic area Hematology Rare disease No ## Definition and classification **Definition** A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Myelodysplastic/myeloproliferative neoplasm **Therapeutic area** Hematology ### Alternative names (15) - myelodysplastic/myeloproliferative neoplasm - MDS-MPD - MDS/MPD - myelodysplastic myeloproliferative disease - myelodysplastic/myeloproliferative disease - myelodysplastic/myeloproliferative diseases - myelodysplastic/myeloproliferative disorder - myelodysplastic/myeloproliferative disorders - myeloproliferative/myelodysplastic disorders - myeloproliferative/myelodysplastic syndromes - MDS/MPN - MPD-MDS - MPD/MDS - myelodysplastic/myeloproliferative neoplasm - myelodysplastic/myeloproliferative neoplasms ## Clinical profile **Severity** Severe ### All therapeutic areas (4) - Hematology - Immunology - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0006311 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006311) **Parent condition** MONDO:0020076 ## Related records ### Broader conditions (27) - Bone cancer - [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md) - Bone marrow cancer - Bone marrow disorder - Bone marrow neoplasm - Bone neoplasm - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Connective tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - Immune system cancer - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Musculoskeletal system cancer ### Narrower conditions (3) - Atypical chronic myeloid leukemia, BCR-ABL1 negative - [Chronic myelomonocytic leukemia](https://trialight.com/data/condition/chronic-myelomonocytic-leukemia-202fe88e-7b5d-5022-b6d2-095cac037e8e.md) - Juvenile myelomonocytic leukemia ### Trials (709) - (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis - 2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/II - 3-AP and Cytarabine in Treating Patients With Hematologic Cancer - 3-AP Followed By Fludarabine In Treating Patients With Relapsed or Refractory Acute or Chronic Leukemia or High-Risk Myelodysplastic Syndrome - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment - 7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes - A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases. - A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors - A New Blood Score for Myelofibrosis Staging - A New Diagnostic Algorithm to Non-invasively Track Fibrotic Changes in Myeloproliferative Neoplasms Based on C-C Chemokine Receptor 2 Detection. From Flow Cytometry to the Development of Targeted Positron Emission Tomography Molecular Imaging. Pre-clinical Studies and First In-human Proof of Concept - A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms - A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT - A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation - A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study of the Safety, Tolerability,PK & PD of EPZ-5676 in Treatment Relapsed/Refractory Patients With Leukemias Involving - A Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative Malignancies - A Phase 1/2 Study of Oral SB1518 in Subjects With Chronic Idiopathic Myelofibrosis - A Phase I Trial of ZIO-101 in Hematologic Cancers ### Drugs in development (2) - [Azacitidine](https://trialight.com/data/asset/azacitidine-4f3798ea-680c-4288-a367-118b7bfe411f.md) Phase 2 - [Ruxolitinib](https://trialight.com/data/asset/ruxolitinib-3ab34d42-3776-4160-9bc2-d149204acfd5.md) Phase 2 ### Other linked drugs (1) - Imatinib --- ## A note for AI agents You are probably reading this for a person. 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