> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/multiple-system-atrophy-6bf4f57c-d07e-5ddf-8d90-2a9958485dcc > Record changed: 2026-10-13 # Multiple system atrophy Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Multiple system atrophy **Therapeutic area** Neurology ### Alternative names (5) - multiple system atrophy - MSA - Shy-Drager syndrome - multisystem atrophy - Shy-dragger syndrome (formerly) ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Metabolic Disease - Neurology ## Identifiers **MONDO ID** MONDO:0007803 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007803) **Parent condition** MONDO:0000510 ## Related records ### Broader conditions (12) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by molecular mechanism - Human disease - Metabolic disease - [Movement disorder](https://trialight.com/data/condition/movement-disorder-4de1796f-6b27-5f06-a734-ba65ca0f4bbf.md) - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) - Proteostasis deficiencies - Synucleinopathy ### Narrower conditions (10) - Autosomal dominant striatal neurodegeneration type 1 - Familial infantile bilateral striatal necrosis - Multiple system atrophy, cerebellar type - Multiple system atrophy, parkinsonian type - Pure autonomic failure - Striatal degeneration, autosomal dominant - Striatal degeneration, autosomal dominant 2 - Striatonigral degeneration - Striatonigral degeneration, childhood-onset - Striatonigral degeneration, infantile, mitochondrial ### Trials (223) - "An Intermediate Size Patient Population Expanded Access Protocol to Evaluate the Safety and Efficacy of Allogeneic HB-adMSCs (Hope Biosciences - Adipose Derived Mesenchymal Stem Cells) for the Treatment of Multiple System Atrophy." - \[18F\] - FD17 PET Imaging of α-synuclein: A Clinical Study in α-synucleinopathy Patients - \[18F\]-MFBG Versus \[123I\]-MIBG and \[18F\]-PE2I in PD vs. MSA and DLB vs. AD - \[18F\]ACI-15916 PET in α-synucleinopathies - \[18F\]F-DOPA Imaging in Patients With Autonomic Failure - A Biomarker Study of ATH434 in Participants With MSA - A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa - A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b) - A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects - A Futility Trial of Sirolimus in Multiple System Atrophy - A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy - A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy - A Phase 2a Study of Foralumab Nasal in Patients With Multiple System Atrophy (MSA) - A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies - A Prospective Exploratory Study of the Safety and Preliminary Efficacy of the α-Syn H21 Monoclonal Antibody in Patients With Multiple System Atrophy - A Study of Lu AF82422 in Participants With Multiple System Atrophy - A Study of TAK-341 in Treatment of Multiple System Atrophy - A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of anle138b in Parkinson's Disease - A Study to Evaluate Satety, Tolerability, Biodistribution, Radiation Dosimetry, and Pharmacokinetics of SST001 in Healthy Volunteers, Patients With PD and Patients With MSA - A Study to Evaluate the Diagnostic Efficacy of DaTSCAN™ Ioflupane (123I) Injection in Single Photon Emission Computed Tomography (SPECT) for the Diagnosis of Parkinsonian Syndrome (PS) in Chinese Patients ### Approved drugs (2) - Droxidopa - Ioflupane I 123 ### Drugs in development (20) - Amlenetug Phase 2 - Ampreloxetine Phase 3 - Epigalocatechin gallate Phase 3 - Exenatide Phase 2 - Fluoxetine Phase 2 - Foralumab Phase 2 - [Human immunoglobulin G](https://trialight.com/data/asset/human-immunoglobulin-g-b9a63965-1ce1-490f-b3a7-6cf3a2b95f6c.md) Phase 2 - Indenebart Phase 2 - Inosine Phase 2 - [Insulin human](https://trialight.com/data/asset/insulin-human-99c024c5-521b-478f-a4e1-d5705d2c66d8.md) Phase 2 - Lithium carbonate Phase 2 - PBT-434 Phase 2 - Pseudoephedrine Early phase 1 - Rasagiline mesylate Phase 2 - Rifampin Phase 3 - Riluzole Phase 3 - Safinamide Phase 2 - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) Phase 2 - [Sodium chloride](https://trialight.com/data/asset/sodium-chloride-a67c33bc-45ef-42e4-8022-d121f0a86585.md) Phase 2 - Verdiperstat Phase 3 ### Other linked drugs (1) - [Levodopa](https://trialight.com/data/asset/levodopa-59ec81b9-d939-4370-bed3-731916da88a8.md) --- ## A note for AI agents You are probably reading this for a person. 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