> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375 > Record changed: 2026-10-13 # Multiple sclerosis Therapeutic area Immunology Rare disease Yes ## Definition and classification **Definition** A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Multiple sclerosis **Therapeutic area** Immunology ### Alternative names (3) - multiple sclerosis - generalised multiple sclerosis - generalized multiple sclerosis ## Clinical profile **Disease mechanisms** - Developmental **Severity** Severe ### All therapeutic areas (2) - Immunology - Neurology ## Identifiers **MONDO ID** MONDO:0005301 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005301) **Parent condition** MONDO:0000568 ## Related records ### Broader conditions (16) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - Autoimmune disorder of central nervous system - Autoimmune disorder of the nervous system - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - CNS demyelinating autoimmune disease - Demyelinating disease - Demyelinating disease of central nervous system - Disease - Disease by body system or component - Disease by developmental or physiological process - Disorder of development or morphogenesis - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) ### Narrower conditions (7) - [Chronic progressive multiple sclerosis](https://trialight.com/data/condition/chronic-progressive-multiple-sclerosis-99de35e9-2d98-5ec1-815e-693482f47d80.md) - Marburg acute multiple sclerosis - Pediatric multiple sclerosis - Primary progressive multiple sclerosis - [Progressive relapsing multiple sclerosis](https://trialight.com/data/condition/progressive-relapsing-multiple-sclerosis-3988455b-b8b3-5584-a1f4-703f7fdd9533.md) - [Relapsing-remitting multiple sclerosis](https://trialight.com/data/condition/relapsing-remitting-multiple-sclerosis-dbe6fc02-bfff-56b7-8299-64be5abdf415.md) - [Secondary progressive multiple sclerosis](https://trialight.com/data/condition/secondary-progressive-multiple-sclerosis-c559b49a-e39f-545b-aab5-dd41263dd2f6.md) ### Trials (3,136) - " Treating MS Patients With Lower Extremity Spasticity Using Dysport" - "Balance, Gait, and Motion Analysis in Multiple Sclerosis" - "Evaluation of Usability and Safety of the Self-balancing Walking System Atalante in Patients With Multiple Sclerosis" - "HB-adMSCs for the Treatment of Patients With Multiple Sclerosis" - "Outwalk MS" - Benefits of Outdoor Walking in Multiple Sclerosis - "Selfie" Videos: A Novel, Patient-centered, Comprehensive Approach to Measuring Function in MS - \[11C\]-PBR28 Positron Emission Tomography Study to Evaluate the Effect of ABT 555 in Subjects With Relapsing Forms of Multiple Sclerosis - \[18F\]PBR111 and Microglial Activation in Multiple Sclerosis - 12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients - 12-week Study to Evaluate RebiSmart™ Suitability for Self Injection in Relapsing Multiple Sclerosis. - 3 Meter Backwards Walk Test and Multiple Sclerosis - 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis. - 3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON) - 3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME) - 3D Phase Sensitive Inversion Recuperation MRI to Detect and Characterize Multiple Sclerosis Spinal Cord Lesions - 5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis - A "negative"dendritic Cell-based Vaccine for the Treatment of Multiple Sclerosis: a First-in-human Clinical Trial - A 12 -Month, Open-label, Multi-center Study to Explore the Health Outcomes of FTY720 - A 12 Week Randomized Open Label Parallel Group Multicenter Study to Evaluate Bioequivalence of 20 mg Subcutaneous Ofatumumab Injected by Pre-filled Syringe or Autoinjector in Adult RMS Patients - A 3-year Multi-center Study to Describe Changes of OCT Parameters Under Treatment With Gilenya® ### Approved drugs (35) - Alemtuzumab - Baclofen - Cladribine - Corticotropin - Daclizumab - Dalfampridine - Dantrolene sodium - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) - Dimethyl fumarate - Diroximel fumarate - Fingolimod hydrochloride - Fingolimod lauryl sulfate - Glatiramer acetate - [Interferon beta-1A](https://trialight.com/data/asset/interferon-beta-1a-c695dc52-c393-4593-914b-f06ff7288c32.md) - Interferon beta-1B - Lincomycin - [Methylprednisolone](https://trialight.com/data/asset/methylprednisolone-f881999e-4ad3-485a-8fbe-6e7b979365f9.md) - Methylprednisolone sodium succinate - Mitoxantrone hydrochloride - Monomethyl fumarate ### Drugs in development (200) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 2 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 3 - Acetazolamide Phase 2 - Acetylcysteine Phase 2 - Acyclovir sodium Phase 3 - Alfuzosin Phase 2 - Amantadine Phase 3 - Amantadine hydrochloride Phase 3 - Amifampridine Phase 3 - Amiselimod hydrochloride Phase 2 - [Anakinra](https://trialight.com/data/asset/anakinra-2c0352ee-cb20-46c5-bd87-6350d9024e75.md) Phase 1 - Arbaclofen placarbil Phase 3 - Armodafinil Phase 2 - ASP-4058 Phase 1 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - [Atacicept](https://trialight.com/data/asset/atacicept-58997791-8042-4d0f-ac69-564cf9e78d1d.md) Phase 2 - Atorvastatin Phase 2 - Azficel-T Phase 3 - Azithromycin Phase 2 - Belimumab Phase 2 ### Other linked drugs (7) - Aspartic acid - Gadolinium - Gadoteridol - Incobotulinumtoxina - Leflunomide - Sodium phosphate, dibasic, anhydrous - TOL-101 --- ## A note for AI agents You are probably reading this for a person. 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