> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/multiple-endocrine-neoplasia-type-2a-d7f126fe-0dc5-563d-b580-bd17f918d5c1 > Record changed: 2026-10-13 # Multiple endocrine neoplasia type 2A Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the RET gene, characterized by an increased risk of medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Multiple endocrine neoplasia type 2A **Therapeutic area** Oncology ### Alternative names (21) - multiple endocrine neoplasia type 2A - MEA type 2a - MEA type II - MEN2A - RET-related multiple endocrine neoplasia type 2A - Sipple syndrome - men 2A - men type 2a - men type II - multiple endocrine adenomatosis type 2A - multiple endocrine adenomatosis type 2a - multiple endocrine adenomatosis type II - multiple endocrine adenomatosis, type II - multiple endocrine neoplasia IIA - multiple endocrine neoplasia type 2A - multiple endocrine neoplasia type II - multiple endocrine neoplasia, type II - ptc syndrome - men-2A syndrome - multiple endocrine neoplasia, type IIA - pheochromocytoma and amyloid producing medullary thyroid carcinoma ## Clinical profile **Severity** Severe ### Disease mechanisms (4) - Developmental - Genetic - Hereditary - Syndromic ### All therapeutic areas (2) - Endocrinology - Oncology ## Identifiers **MONDO ID** MONDO:0008234 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0008234) **Parent condition** MONDO:0000426 ## Related records ### Broader conditions (33) - Autosomal dominant disease - Autosomal genetic disease - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Disease susceptibility - Disorder of development or morphogenesis - Endocrine gland neoplasm - [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md) - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Hereditary disease - Hereditary neoplastic syndrome - Human disease - Inherited disease susceptibility - Malignant endocrine neoplasm ### Trials (18) - A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers - A Phase 1, Randomized, Placebo-Controlled, Ascending Cohort, Dose Escalation Study in Normal Healthy Volunteers - A Rollover Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer - Cinacalcet to Treat Familial Primary Hyperparathyroidism - [Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer](https://trialight.com/data/trial/clinical-trial-evaluating-the-safety-tolerability-and-3330e9b1-dff1-467c-8b21-e9c48100ce5a.md) - Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer - Familial Investigations of Childhood Cancer Predisposition - Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients - Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors - Prospective Study on Resistance-associated Mutations in Metastatic Lung Cancer - PTC-Guided Atorvastatin Plus Axitinib and Toripalimab in Advanced RCC - Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford - Safety, Efficacy, and Tolerability of BOS172738 in Patients With Advanced Rearranged During Transfection (RET) Gene-Altered Tumors - Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer - Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals Patients - The Role of Trop2 in Radioactive Iodine-131 Therapy Sensitivity in Papillary Thyroid Carcinoma - Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer - Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor --- ## A note for AI agents You are probably reading this for a person. 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