> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/metabolic-dysfunction-associated-steatohepatitis-05fad825-0fff-55c9-8746-0cb406b65c65 > Record changed: 2026-10-13 # Metabolic dysfunction-associated steatohepatitis Therapeutic area Endocrinology Rare disease No ## Definition and classification **Definition** Metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis or NASH) is a type of fatty liver disease. It often develops due to a metabolic disorder, such as obesity or diabetes, resulting in a toxic buildup of fat in the liver. It is the most severe form of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty liver disease or NAFLD). **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Metabolic dysfunction-associated steatohepatitis **Therapeutic area** Endocrinology ### Alternative names (6) - metabolic dysfunction-associated steatohepatitis - MASH - NASH - NASH - nonalcoholic steatohepatitis - non-alcoholic steatohepatitis - nonalcoholic steatohepatitis ## Clinical profile **Disease mechanisms** - Inflammatory **Severity** Moderate ### All therapeutic areas (2) - Endocrinology - Gastroenterology ## Identifiers **MONDO ID** MONDO:0007027 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007027) **Parent condition** MONDO:0002251 ## Related records ### Broader conditions (12) - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md) - Fatty liver disease - [Hepatitis](https://trialight.com/data/condition/hepatitis-6b771058-c7ad-5a5f-aa35-ea69998a764a.md) - Hepatobiliary disorder - Human disease - Inflammatory disease - [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) - [Metabolic dysfunction-associated steatotic liver disease](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatotic-liver-disease-beb92cb4-74bc-5e17-96f1-97aeed54ab35.md) ### Trials (602) - "Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases". - 2-Week Study In People With Nonalcoholic Fatty Liver Disease - A 3-part Study to Evaluate Safety, Tolerability, Food Effect and Drug-drug Interactions of RXC007 in Healthy Volunteers - [A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)](https://trialight.com/data/trial/a-clinical-study-of-efinopegdutide-in-participants-with-200ac92c-068f-4d10-9724-05b6aa94d553.md) - A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) - A Clinical Study to Evaluate the Efficacy and Safety of Aramchol in Subjects With NASH (ARMOR) - A Clinical Trial of BGT-002 Tablets in Subjects With Nonalcoholic Steatohepatitis - A Clinical Trial to Evaluate the Efficacy and Safety of Two Aramchol Doses Versus Placebo in Patients With NASH - A Double-blind Study to Assess 2 Doses of an Investigational Product for 16 Weeks in Participants With Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus - A Drug-drug Interaction Study to Investigate the Effect of Coadministration of EDP-305 on the PK of a Combined Oral Contraceptive in Healthy Female Subjects - A Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD) - A Microdose Trial Investigating Binding of \[68Ga\]Ga-DOTA-CYS-ATH001 in Healthy Subjects and Different Patient Groups. - A Multi-country, Cross-sectional Quantitative Study Exploring Awareness, Understanding, and Perceptions of the Relation Between Cardiorenal Metabolic Conditions and MASLD/MASH Among Healthcare Providers, People With MASLD/MASH, and At-risk Population - A Multicenter, Double-blind, Placebo-randomized Controlled Clinical Study on the Treatment of Non-alcoholic Steatohepatitis With Tibetan Drug Langqing Atar - A Multiple Ascending Dose Study of Pegozafermin in Participants With Biopsy Confirmed Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) and at High Risk of NASH - A One-Year, Randomized, Double-Blind, Placebo-Controlled Trial of Rosiglitazone in Non-Alcoholic Steatohepatitis - A Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of VSA006 in Chinese NASH Patients - A Phase 2 Study of Elobixibat in Adults With NAFLD or NASH - A Phase 2b Study of Icosabutate in Fatty Liver Disease - A Phase 2b, Study Evaluating Miricorilant in Adult Patients With Nonalcoholic Steatohepatitis/Metabolic Dysfunction-Associated Steatohepatitis (MONARCH) ### Approved drugs (1) - Resmetirom ### Drugs in development (80) - Aldafermin Phase 2 - ASP-9831 Phase 2 - Atorvastatin Phase 2 - Belapectin Phase 2 - Betaine Phase 2 - Caffeine Phase 1 - Cenicriviroc Phase 3 - Chiglitazar Phase 2 - Cilofexor Phase 2 - Clesacostat Phase 2 - Colesevelam hydrochloride Phase 2 - Cudetaxestat Phase 1 - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) Phase 3 - [Digoxin](https://trialight.com/data/asset/digoxin-9928e38a-813e-4948-9d65-9088ba40a442.md) Phase 2 - [Efinopegdutide](https://trialight.com/data/asset/efinopegdutide-4155fff3-ef7d-48c1-8936-dcdd5f48bf0b.md) Phase 2 - [Efruxifermin](https://trialight.com/data/asset/efruxifermin-92f34399-5e95-4620-8063-37948c46eee4.md) Phase 3 - Elafibranor Phase 2 - Elobixibat Phase 2 - Emricasan Phase 2 - Esomeprazole Phase 1 ### Other linked drugs (4) - Alanine - Hydroxychloroquine - Taurursodiol - Ursodiol --- ## A note for AI agents You are probably reading this for a person. 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