> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/metabolic-disease-3d73c19d-b8c8-5be8-add5-77c7d794dacd > Record changed: 2026-11-04 # Metabolic disease Therapeutic area Metabolic Disease Rare disease No ## Definition and classification **Definition** A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Metabolic disease **Therapeutic area** Metabolic Disease ### Alternative names (7) - metabolic disease - disorder of metabolic process - metabolic disorder - Metabolic Disorder, Glucose - Metabolic Disorders - metabolic process disease - Nutritional and Metabolic Disease ## Clinical profile **All therapeutic areas** - Metabolic Disease Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005066) **Severity** Unknown ## Identifiers **MONDO ID** MONDO:0005066 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005066) **Parent condition** MONDO:7770007 ## Related records ### Broader conditions (3) - Disease - Disease by developmental or physiological process - Human disease ### Narrower conditions (2,217) - 2-aminoadipic 2-oxoadipic aciduria - 2-hydroxyglutaric aciduria - 2-methylacetoacetyl CoA thiolase deficiency - 2-methylbutyryl-CoA dehydrogenase deficiency - 3-hydroxy-3-methylglutaric aciduria - 3-hydroxy-3-methylglutaryl-CoA synthase deficiency - 3-hydroxyacyl-CoA dehydrogenase deficiency - 3-hydroxyisobutyric aciduria - 3-hydroxyisobutyryl-CoA hydrolase deficiency - 3-methylcrotonyl-CoA carboxylase 1 deficiency - 3-methylcrotonyl-CoA carboxylase 2 deficiency - 3-methylcrotonyl-CoA carboxylase deficiency - 3-methylglutaconic aciduria - 3-methylglutaconic aciduria type 1 - 3-methylglutaconic aciduria type 3 - 3-methylglutaconic aciduria type 4 - 3-methylglutaconic aciduria type 5 - 3-methylglutaconic aciduria type 8 - 3-methylglutaconic aciduria type 9 - 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome ### Trials (1,253) - "Beverage Hydration Index" of Commercial Therapeutic Beverages - "SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia - 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children - 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children - 4D-310 in Adults With Fabry Disease and Cardiac Involvement - A 2-part, Phase 1b Clinical Study Designed to Evaluate the Safety, PK, and Efficacy of CRB-913 in Participants With Obesity - A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331) - A Clinical Research on Disease Progression and Intervention of Chronic HepatitisB - A Clinical Study to Map the HLA Genomic Region in the Greek Population - A Clinical Trial to Assess the Efficacy and Tolerance of a Berberine-based Nutraceutical Formula to Aid Blood Sugar Regulation and Metabolism - A Clinical Trial to Evaluate the Effects of an Electrolyte Supplement on Women's Wellness - A Clinical Trial to Evaluate the Preference Regarding Convenience of Medication and Efficacy/Safety of SUGAMET®XR Tablet 5/1000mg - A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters - A Dose-finding Study to Evaluate mRNA-3210 in Participants With Phenylketonuria - A Dose-Ranging Study With Vupanorsen (TRANSLATE-TIMI 70) - A Feasibility Trial of a Bhangra Folk Dance Intervention to Improve Metabolic Health in Older Indian Women in the UK - A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia - A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH) - A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501 - A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II ### Approved drugs (6) - Alendronate sodium - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) - Eliglustat tartrate - Saxagliptin - Taliglucerase alfa - Velaglucerase alfa ### Drugs in development (34) - Acarbose Phase 3 - Afegostat tartrate Phase 2 - [Allopurinol](https://trialight.com/data/asset/allopurinol-31075c5e-c121-4498-9ea1-d2c48b7a7267.md) Phase 1 - Antilymphocyte immunoglobulin (horse) Phase 2 - Apocynin Phase 1 - Bumetanide Phase 1 - Busulfan Phase 1 - Dextrose Phase 2 - [Empagliflozin](https://trialight.com/data/asset/empagliflozin-09301932-ac0f-4eb7-8d1d-bd13fdbb6ab8.md) Phase 2 - Evinacumab Phase 1 - Fenofibrate Phase 3 - [Fludarabine](https://trialight.com/data/asset/fludarabine-e03241fb-ac4f-4851-ae4f-6e8dad4f1d28.md) Phase 1 - Hydrogen Phase 1 - KD3010 Phase 1 - Kisspeptin Phase 1 - Kisspeptin-10 Phase 1 - Lovastatin Phase 1 - Melatonin Phase 1 - [Metformin](https://trialight.com/data/asset/metformin-0292cbe3-3a2f-4db7-b783-270ef048c3b4.md) Phase 3 - Omega-3-acid ethyl esters Phase 3 ### Other linked drugs (4) - Aladorian - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) - [Semaglutide](https://trialight.com/data/asset/semaglutide-0f0980aa-d386-4209-8f14-80da83c40d80.md) - [Valproic acid](https://trialight.com/data/asset/valproic-acid-48e1faf9-d01e-4607-a2c6-6316492c15df.md) --- ## A note for AI agents You are probably reading this for a person. 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