Meningococcal meningitis
Therapeutic area
Infectious Disease
Rare disease
Yes
- Definition
- An acute bacterial disease caused by Neisseria meningitides that presents usually, but not always, with a rash (non blanching petechial or purpuric rash), progressively developing signs of meningitis (fever, vomiting, headache, photophobia, and neck stiffness) and later leading to confusion, delirium and drowsiness. Neck stiffness and photophobia are often absent in infants and young children who may manifest nonspecific signs such as irritability, inconsolable crying, poor feeding, and a bulging fontanel. Meningococcal meningitis may also present as part of early or late onset sepsis in neonates. The disease is potentially fatal. Surviving patients may develop neurological sequelae that include sensorineural hearing loss, seizures, spasticity, attention deficits and intellectual disability.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Meningococcal meningitis
- Alternative names
- meningococcal meningitis
- Therapeutic area
- Infectious Disease
- Severity
- Severe
- Acquired
- Inflammatory
- Infectious Disease
- Neurology
- MONDO ID
- MONDO:0018059
- Parent condition
- MONDO:0005373
Related records
Broader conditions (18)
- Bacterial infectious disease
- Bacterial meningitis
- Central nervous system disorder
- Central nervous system infectious disorder
- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disease by etiologic mechanism
- Disease of primarily extrinsic mechanism
- Encephalomyelitis
- Human disease
- Infectious disease
- Infectious disorder of the nervous system
- Infectious meningitis
- Inflammatory disease
- Meningitis
- Meningococcal infection
- Nervous system disorder
Trials (124)
- A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 18-59 Year Olds
- A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 7 to 17 Year Olds
- A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in a 4 to 6 Year-old Population
- A Clinical Trial of the ACYW135 Group Meningococcal Polysaccharide-Conjugated Vaccine (CRM197 Vector)
- A Clinical Trial to Evaluate the Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years
- A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years
- A Human Controlled Infection Study with Neisseria Lactamica in Malian Adults
- A Multi-center, Observer-blind, Placebo-controlled, Randomized Study to Evaluate the Immunogenicity and Safety of MenACWY in Adolescents and Adults in Korea
- A Phase 3b Study to Assess the Safety of Novartis Meningococcal B Recombinant Vaccine When Administered in Healthy At-risk Adults
- A Phase 3B, Open Label, Multi-Center Study to Evaluate the Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine When Administered Alone to Healthy Infants According to Different Immunization Schedules and to Healthy Children Aged 2 to 10 Years
- A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults
- A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents
- A Phase III Clinical Trial of the Group A and C Meningococcal Polysaccharide Vaccine
- A Phase III Clinical Trial of the Group A Meningococcal Polysaccharide Vaccine
- A Single-center, Open Trials to Evaluate the Safety of Freeze-dried Group ACYW135 Meningococcal Conjugate Vaccine
- A Sourcing Study to Collect Human Blood Samples From Healthy Adults
- A Study Assessing Colonisation & Immunogenicity After Nasal Inoculation With N. Lactamica and Eradication on Day 4 or 14
- A Study Evaluating Safety And Immunogenicity Of Meningococcal B Rlp2086 Vaccine In Adolescents
- A Study of 2 Doses of Menactra®, a Meningococcal Conjugate Vaccine in Healthy Toddlers
- A Study of the ACYW135 Meningococcal Polysaccharide Conjugate Vaccine
Approved drugs (6)
- Neisseria meningitidis adhesin A
- Neisseria meningitidis factor H binding protein
- Neisseria meningitidis neisserial heparin binding antigen
- Neisseria meningitidis oligosaccharide conjugated to corynebacterium diphtheriae CRM197
- Neisseria meningitidis outer membrane vesicles
- Neisseria meningitidis polysaccharide conjugated to tetanus toxoid
Drugs in development (3)
- Diphtheria toxoid Phase 3
- Pertussis vaccine Phase 3
- Tetanus toxoid Phase 3