> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/mantle-cell-lymphoma-9d77f5cf-7a74-5003-a8f9-f66d3b607b00 > Record changed: 2026-10-13 # Mantle cell lymphoma Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the \`\`mantle zone''. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Mantle cell lymphoma **Therapeutic area** Hematology ### Alternative names (7) - mantle cell lymphoma - LCM - MCL - classical mantle cell lymphoma - mantle cell lymphoma - mantle zone lymphoma - lymphoma, mantle cell ## Clinical profile **Severity** Severe ### All therapeutic areas (3) - Hematology - Immunology - Oncology ## Identifiers **MONDO ID** MONDO:0018876 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0018876) **Parent condition** MONDO:0017595 ## Related records ### Broader conditions (19) - Aggressive B-cell non-Hodgkin lymphoma - [B-cell neoplasm](https://trialight.com/data/condition/b-cell-neoplasm-ffd0710d-7dbd-55bc-a4a5-3c1cf532bac2.md) - [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) - Cancer or benign tumor - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Leukocyte disorder - Lymphoid hemopathy - Lymphoid neoplasm - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) - Neoplasm - Neoplastic disease or syndrome - [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) ### Narrower conditions (2) - Gastric mantle cell lymphoma - Splenic mantle cell lymphoma ### Trials (1,221) - "Don't Eat me" Signal in Hematological Malignancies: CD24 as New Target to Improve Anti-cancer Immunity. - 10-Propargyl-10-Deazaaminopterin in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma - 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone Marrow Disorder - 131I-rituximab for Relapsed or Refractory Follicular or Mantle Cell Lymphoma - 17-AAG in Treating Patients With Relapsed or Refractory Anaplastic Large Cell Lymphoma, Mantle Cell Lymphoma, or Hodgkin's Lymphoma - 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in Treating Patients With an Advanced Solid Tumor or Lymphoma - 17-DMAG in Treating Patients With Metastatic or Unresectable Solid Tumors or Lymphomas - 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With Relapsed or Refractory Hematologic Cancer - 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Advanced Epithelial Cancer, Malignant Lymphoma, or Sarcoma - 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery - 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis - 3-AP and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma - 3'-Deoxy-3'-\[18F\] Fluorothymidine PET Imaging in Patients With Cancer - 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment - A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies - A Clinical Study of Hanlikang and BTK Inhibitors in the Treatment of Newly Diagnosed Mantle Cell Lymphoma - A Clinical Study of ONCT-808 in Subjects With Relapsed or Refractory B-Cell Malignancies - A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma ### Approved drugs (10) - Acalabrutinib - [Acalabrutinib maleate](https://trialight.com/data/asset/acalabrutinib-maleate-bfe0df80-e311-4f23-9e92-799d6a8c070f.md) - Bortezomib D-mannitol - Brexucabtagene autoleucel - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) - Lenalidomide hydrochloride monohydrate - Pirtobrutinib - Temsirolimus - [Zanubrutinib](https://trialight.com/data/asset/zanubrutinib-7763b1f8-43b7-49a8-8bc2-ca3940603ee6.md) ### Drugs in development (132) - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Phase 2 - Agatolimod sodium Phase 2 - Alisertib Phase 1 - Alvocidib hydrochloride Phase 1 - AMG-319 Phase 1 - Antineoplaston A10 Phase 2 - Apolizumab Phase 1 - AT-7519 Phase 2 - Axicabtagene ciloleucel Phase 2 - Belinostat Phase 2 - [Bendamustine](https://trialight.com/data/asset/bendamustine-07f7a21f-820a-4423-a534-0d6d0380b382.md) Phase 3 - Bendamustine hydrochloride Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - BMS-387032 Phase 1 - Bryostatin 1 Phase 1 - Buparlisib Phase 2 - Busulfan Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 1 - [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) Phase 2 - Carmustine Phase 3 ### Other linked drugs (3) - [Bortezomib](https://trialight.com/data/asset/bortezomib-35a853cf-26ab-4a4c-a405-ae671d364aad.md) - Curcumin - Orvacabtagene autoleucel --- ## A note for AI agents You are probably reading this for a person. 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