> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/malignant-glioma-2d06cbb2-f53c-5f13-b850-6e7eba2b573c > Record changed: 2026-11-04 # Malignant glioma Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Malignant glioma **Therapeutic area** Oncology ### Alternative names (29) - malignant glioma - Advanced Malignant Glioma - CNS Primary Tumor, NOS (Malignant Glioma) - Glial Cell Tumors - glial cell tumour - glioma, malignant - high grade glioma - High Grade Glioma (HGG) - High Grade Glioma (III or IV) - high-grade glioma - High-Grade Glioma (HGG) - High-Grade Glioma (WHO III-IV) - malignant glial neoplasm - malignant glial tumor - malignant glial tumour - Malignant Glioma (WHO Grade III or IV) - malignant neuroglial neoplasm - malignant neuroglial tumor - malignant neuroglial tumour - Newly Diagnosed High Grade Glioma - Newly Diagnosed High Grade Glioma (HGG) - Newly Diagnosed High-Grade Glioma - Recurrent High Grade Glioma - Recurrent High-Grade Glioma - Recurrent Malignant Glioma And 4 more, listed on the interactive page. ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Neurology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0100342) ## Identifiers **MONDO ID** MONDO:0100342 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0100342) **Parent condition** MONDO:0002714 ## Related records ### Broader conditions (17) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Central nervous system cancer](https://trialight.com/data/condition/central-nervous-system-cancer-14789751-67f7-557a-9c07-30e51513747d.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Central nervous system neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - [Glioma](https://trialight.com/data/condition/glioma-4ac240c4-7ffb-5f08-b793-0b205a4b5d03.md) - High grade malignant neoplasm - Human disease - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplastic disease or syndrome - Nervous system cancer - [Nervous system disorder](https://trialight.com/data/condition/nervous-system-disorder-541eb3ed-9656-574d-babf-28139b060a42.md) - Nervous system neoplasm - Neuroepithelial neoplasm ### Narrower conditions (99) - Adult anaplastic ependymoma - Adult brain ependymoma - Adult brainstem astrocytoma - Adult brainstem glioma - Adult brainstem gliosarcoma - Adult brainstem mixed glioma - Adult glioblastoma - Adult malignant schwannoma - Adult oligodendroglioma - Adult spinal cord ependymoma - Adult spinal cord glioblastoma - Anaplastic astrocytoma - Anaplastic ependymoma - Anaplastic oligoastrocytoma - Anaplastic oligodendroglioma - Astrocytoma, IDH-mutant, grade 2 - Astrocytoma, IDH-mutant, grade 3 - Astrocytoma, IDH-mutant, grade 4 - Brain glioblastoma - Brain glioma ### Trials (392) - 131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma - 18F-DOPA-PET in Finding Tumors in Patients With Newly Diagnosed Gliomas Undergoing Radiation Therapy - 18F-DOPA-PET in Planning Surgery in Patients With Gliomas - 18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy - 18F-FET-PET/MRI vs Standard MRI Alone for Stereotactic RadioTherapy Planning for High Grade Brain Gliomas - 18F-Fluciclovine PET-MRI in High-grade Glioma - 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas - 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignant Tumor - 68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma - 9-ING-41 in Patients With Advanced Cancers - A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma - A Continuation Protocol for Patients Previously Enrolled in a Study of Toca 511 - A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors - A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patients With Progressive, Refractory, or Recurrent High Grade Gliomas - A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial - A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions - A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. - A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma - A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma - A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors ### Approved drugs (3) - Aminolevulinic acid hydrochloride - Carmustine - [Temozolomide](https://trialight.com/data/asset/temozolomide-3fac1b09-bcc5-4875-871e-2cc6460dc731.md) ### Drugs in development (240) - 6-O-benzylguanine Phase 2 - Abacavir Phase 1 - [Abemaciclib](https://trialight.com/data/asset/abemaciclib-602a9f33-bc37-4cf5-8790-5d87472b99d5.md) Early phase 1 - AC-480 Phase 1 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 2 - ACT-001 Phase 2 - Afatinib Phase 2 - [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Phase 1 - Aglatimagene besadenovec Phase 1 - Alanine Early phase 1 - Alanosine Phase 1 - Aldesleukin Phase 1 - Alisertib Phase 1 - Alisertib sodium Phase 1 - AMG-404 Phase 1 - Amino acids Phase 2 - Aminolevulinic acid Phase 1 - ANG1005 Phase 1 - Antineoplaston A10 Phase 2 - Armodafinil Phase 2 ### Other linked drugs (5) - Alovudine F-18 - Busulfan - Lacosamide - MAB-425 - [Rivaroxaban](https://trialight.com/data/asset/rivaroxaban-3f354e10-6d35-4989-9e00-318be65808fb.md) --- ## A note for AI agents You are probably reading this for a person. 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