> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/malaria-54828cac-9b96-5833-93e2-e012d4505853 > Record changed: 2026-10-13 # Malaria Therapeutic area Hematology Rare disease Yes ## Definition and classification **Definition** Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. In general, malaria is a curable disease if diagnosed and treated promptly and correctly.Treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Malaria **Alternative names** - malaria **Therapeutic area** Hematology ## Clinical profile **Disease mechanisms** - Acquired **Severity** Severe ### All therapeutic areas (2) - Hematology - Infectious Disease ## Identifiers **MONDO ID** MONDO:0005136 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005136) **Parent condition** MONDO:0002428 ## Related records ### Broader conditions (11) - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Erythrocyte disorder - Hematologic disorder - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Parasitic infectious disease - Protozoa infectious disease - [Vector-borne disease](https://trialight.com/data/condition/vector-borne-disease-3bb0ac2f-6d8c-5d5c-9027-84b59b878a24.md) ### Narrower conditions (7) - Blackwater fever - Cerebral malaria - Mixed malaria - [Plasmodium falciparum malaria](https://trialight.com/data/condition/plasmodium-falciparum-malaria-5e0103dd-4e60-581d-924b-3435883b51f8.md) - Plasmodium malariae malaria - Plasmodium ovale malaria - Plasmodium vivax malaria ### Trials (1,136) - A Challenge Study to Assess the Blood-stage Efficacy of Full-length SUM-101 Malaria Vaccine Candidate - A Challenge Study to Assess the Protective Efficacy of Two Malaria Vaccine Candidates - A Challenge Study to Assess the Safety, Immunogenicity and Efficacy of a Malaria Vaccine Candidate - A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults - A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Naïve Adults: Heterologous vs. Homologous Controlled Human Malaria Infection and Reduction in Number of Doses - A Clinical Trial to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 Pfs25-IMX313 and MVA Pfs25-IMX313 - A Clinical Trial to Evaluate the Safety, Efficacy and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria - A Cluster Randomized Trial to Evaluate Long Lasting Insecticidal Hammocks to Prevent Forest Malaria in Vietnam - A Cluster-randomised Trial of Interventions to Improve Antimalarial Prescribing With Malaria Tests - A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) - A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated Malaria - A Comparative Study of Azithromycin and S-P as Prophylaxis in Pregnant HIV+ Patients - A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients - A Comparison of Diagnostic Approaches for Malaria and Pneumonia - A Dose-escalation Study to Investigate Safety and Toleration of OZ439 - A FIH Study to Investigate the Safety, Tolerability and PK of P218 - A First Time in Human Study in Healthy Volunteers to Investigate a New Medicine to Treat Malaria - A Longitudinal Systems Biological Analysis of Naturally Acquired Malaria Immunity in Mali - A Microdose Study in Healthy Subjects to Describe Intravenous Pharmacokinetics of GSK3191607 - A New Approach to Deliver Malaria Preventions to Pregnant Women at a Community Level in Uganda ### Approved drugs (25) - Amodiaquine - Artemether - Artemisinin - Artemotil - Artenimol - [Artesunate](https://trialight.com/data/asset/artesunate-586f50f5-bb73-43da-8a18-5a2743da577b.md) - Atovaquone - Chloroquine - Chloroquine phosphate - [Doxycycline](https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58.md) - Halofantrine - Hydroxychloroquine - Hydroxychloroquine sulfate - [Lumefantrine](https://trialight.com/data/asset/lumefantrine-5a02c559-879a-4fc5-808f-895181937743.md) - Mefloquine - Mefloquine hydrochloride - Primaquine - Proguanil - Proguanil hydrochloride - Pyrimethamine ### Drugs in development (80) - Abamectin Phase 3 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 3 - Agatolimod Phase 1 - Agatolimod sodium Phase 1 - Albendazole Phase 3 - Albitiazolium Phase 2 - Albitiazolium bromide Phase 2 - [Aluminum hydroxide](https://trialight.com/data/asset/aluminum-hydroxide-a0230a1f-a5e2-439f-baa2-2b988b59e46d.md) Phase 1 - AQ-13 Phase 2 - Artefenomel Phase 2 - Artemisin Phase 3 - Azithromycin Phase 3 - Bromhexine Early phase 1 - Cabamiquine Phase 2 - Chlorproguanil Phase 3 - [Cipargamin](https://trialight.com/data/asset/cipargamin-a39a1487-b981-492f-a4bd-eef13926cc13.md) Phase 2 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 3 - Clindamycin Phase 3 - Cobicistat Phase 1 - Cycloguanil pamoate Phase 2 ### Other linked drugs (8) - Buthionine sulfoximine - Cycloguanil - Meprobamate - OZ277 - Pepstatin - Piperaquine tetraphosphate - Triclosan - [Ustekinumab](https://trialight.com/data/asset/ustekinumab-323cb2e2-e906-4997-ac57-d82c7f7c399d.md) --- ## A note for AI agents You are probably reading this for a person. 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