> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a > Record changed: 2026-10-13 # Major depressive disorder Therapeutic area Psychiatry Rare disease No ## Definition and classification **Definition** An episode of depression lasting two or more weeks without an intervening episode of mania. **Genetic basis** Yes **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Major depressive disorder **Therapeutic area** Psychiatry ### Alternative names (9) - major depressive disorder - major depressive disorder 1 - major depressive disorder 2 - major depression - major depressive disorder - major depressive disorder and accelerated response to antidepressant drug treatment - major depressive disorder, response to citalopram therapy in - unipolar depression - unipolar depression, susceptibility to ## Clinical profile **Severity** Moderate ### All therapeutic areas (2) - Neurology - Psychiatry ## Identifiers **MONDO ID** MONDO:0002009 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0002009) **Parent condition** MONDO:0002050 ## Related records ### Broader conditions (11) - [Brain disorder](https://trialight.com/data/condition/brain-disorder-4e393319-afcc-52a0-8ac4-4c73ea743874.md) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Human disease - [Mental disorder](https://trialight.com/data/condition/mental-disorder-6dfe385f-02c0-52b1-895d-e6ed79c12e5f.md) - [Mood disorder](https://trialight.com/data/condition/mood-disorder-00c37338-ecb8-5997-bb93-d0ec3e6e3573.md) - Nervous system disorder - Psychiatric disorder ### Narrower conditions (1) - Endogenous depression ### Trials (2,941) - "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder" - "Brexpiprazole (Rexulti™) Safety and Efficacy Among Filipino Patients (RAISE) - A Post Marketing Surveillance Program" - "Mamá, te Entiendo" App-based Intervention for Reducing Depressive Symptoms in Postpartum Women - 40 Hz Light Neurostimulation for Patients With Depression (FELIX) - 5-HTP and Creatine for Depression - 5-HTP and Creatine for Depression R33 Phase - 5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females - 54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide - 54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide - 6 Weeks Right-Amygdala TIS for Depression - 6-week Study Treatment to Evaluate the Safety and Effectiveness of AZD2066 in Patients With Major Depressive Disorder - 8-week of PS128 RCT in Patients With Major Depressive Disorder - A 12-Week, Placebo Controlled Trial of Ziprasidone as Monotherapy for Major Depressive Disorder - A 6 Week Study to Determine the Effectiveness of R228060 in Adult Subjects With Major Depressive Disorder - A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy Of DVS SR In The Treatment Of Child And Adolescent Outpatients With MDD - A 6-Month Open-Label Extension Study to the B2061014 Study to Evaluate the Safety, Tolerability and Efficacy of DVS SR in the Treatment of Children and Adolescents With MDD - A 7-year Assessment on Subject Understanding of ZYBAN/ WELLBUTRIN Associated Risks - A Biological Signature for the Early Differential Diagnosis of Psychosis - A Clinical Evaluation of Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression - A Clinical Study to Evaluate of Single and Multiple Oral Doses of GM-1020 in Patients With MDD ### Approved drugs (88) - Agomelatine - Amineptine - Amitriptyline - Amitriptyline hydrochloride - Amoxapine - [Aripiprazole](https://trialight.com/data/asset/aripiprazole-ca9997bd-e762-4bd5-ae57-3df4e68a30dd.md) - Betaine - Brexanolone - Brexpiprazole - Bupropion - Bupropion hydrobromide - Bupropion hydrochloride - Butriptyline - Citalopram - Citalopram hydrobromide - Clomipramine - Desipramine - Desipramine hydrochloride - Desvenlafaxine - Desvenlafaxine fumarate ### Drugs in development (205) - ABX-002 Phase 1 - Acetylcysteine Early phase 1 - Ademetionine Phase 2 - Adenosine triphosphate Phase 2 - Alaproclate Phase 2 - Albuterol Phase 1 - [Alcohol](https://trialight.com/data/asset/alcohol-94acdb16-f595-4fd2-a9fa-0e1509bc9a8f.md) Phase 1 - Amibegron Phase 3 - Amisulpride Phase 1 - Amitifadine Phase 2 - Amitifadine hydrochloride Phase 2 - Apimostinel Phase 2 - Aprepitant Phase 3 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 2 - Aticaprant Phase 3 - AV-101 Phase 2 - AZD-7268 Phase 2 - AZD2066 Phase 2 - Azetukalner Phase 2 - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) Phase 2 ### Other linked drugs (15) - Amphetamine/dextroamphetamine - [Botulinum toxin type A](https://trialight.com/data/asset/botulinum-toxin-type-a-5a0f3130-910b-4917-87ef-65a743f12642.md) - Carbidopa - [Centanafadine hydrochloride](https://trialight.com/data/asset/centanafadine-hydrochloride-4736b6b5-c46b-48de-abda-0d3a3990ef0d.md) - Choline alfoscerate - Clovoxamine - Cysteamine bitartrate - Ganaxolone - [Golimumab](https://trialight.com/data/asset/golimumab-029e0cce-9d8f-4121-b835-6c4aa307913c.md) - Nicotine - Ropinirole - Sildenafil citrate - Tiomolibdate diammonium - Toludesvenlafaxine hydrochloride - [Zinc sulfate](https://trialight.com/data/asset/zinc-sulfate-89916c92-5761-48ff-8b38-fe26bc5f899c.md) --- ## A note for AI agents You are probably reading this for a person. 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