> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/macular-corneal-dystrophy-ea584523-cd7f-594c-a5e1-046755e8019a
> Record changed: 2026-11-04

# Macular corneal dystrophy

Therapeutic area

Neurology

Rare disease

Yes

## Definition and classification

**Definition**

Macular corneal dystrophy (MCD) is a rare, severe form of stromal corneal dystrophy characterized by bilateral ill-defined cloudy regions within a hazy stroma, and eventually severe visual impairment.

**Genetic basis**

Yes

**Non-human condition**

No

**Rare disease**

Yes

**Listing at source**

Listed

**Condition name**

Macular corneal dystrophy

**Therapeutic area**

Neurology

### Alternative names (9)

- macular corneal dystrophy
- corneal dystrophy Groenouw type II
- Fehr corneal dystrophy
- Macular Dystrophy, Corneal
- Macular dystrophy, corneal type 1
- MCD
- Groenouw type II corneal dystrophy
- macular corneal dystrophy type 1
- Mcdc1

## Clinical profile

**Severity**

Severe

### Disease mechanisms (2)

- Genetic
- Hereditary

Sources for recorded values

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009020)

### All therapeutic areas (2)

- Neurology
- Ophthalmology

Sources for recorded values

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009020)

## Identifiers

**MONDO ID**

MONDO:0009020

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0009020)

**Parent condition**

MONDO:0020213

## Related records

### Broader conditions (18)

- Corneal disorder
- Corneal dystrophy
- Disease
- Disease by body system or component
- Disease by etiologic mechanism
- Disease of genetic or genomic mechanism
- Disorder of orbital region
- Disorder of visual system
- Eye disorder
- [Hereditary disease](https://trialight.com/data/condition/hereditary-disease-df2f8f05-e0c9-5777-8e51-c3b6639743d3.md)
- Hereditary macular dystrophy
- Hereditary neurological disease
- Human disease
- Inherited retinal dystrophy
- [Nervous system disorder](https://trialight.com/data/condition/nervous-system-disorder-541eb3ed-9656-574d-babf-28139b060a42.md)
- Retinal degeneration
- Retinal disorder
- Stromal corneal dystrophy

### Trials (22)

- A Study to Evaluate the Efficacy and Safety of CNTO328 Plus Best Supportive Care in Multicentric Castleman's Disease
- A Study to Evaluate the Safety, Tolerability and PK of SK-09
- An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Podocyte Diseases
- [Atacicept in Multiple Glomerular Diseases](https://trialight.com/data/trial/atacicept-in-multiple-glomerular-diseases-c0bd4719-5c03-432d-be22-82af920d1552.md)
- Cardiac Autonomic Function in Women with Microvascular Coronary Dysfunction
- Castleman Disease Collaborative Network Biobank
- Combined Malonic and Methylmalonic Aciduria (CMAMMA): Gene Identification and Outcome Study
- Fresh Corneal Lenticule Implantation in Macular Corneal Distrophy With Relex Smile Surgery
- Immunophenotyping Profiling in Patients With Primary Nephrotic Syndrome
- International Registry for Patients With Castleman Disease
- Nephrotic Syndrome Study Network
- NEPTUNE Match Study
- Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease
- Safety and Efficacy of Rituximab for Treatment of Multicentric Castleman Disease in Malawi
- Sirolimus in Previously Treated Idiopathic Multicentric Castleman Disease
- Steroid Treatment for Kidney Disease
- Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases
- The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy
- The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)
- Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Disease

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