> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/lymphatic-malformation-cb32a906-af33-504c-ae26-ed6e0aa7c2a0 > Record changed: 2026-11-04 # Lymphatic malformation Therapeutic area Vascular Medicine Rare disease No ## Definition and classification **Definition** Primary lymphedema is caused by anatomic or functional defects in the lymphatic system, resulting in chronic swelling of body parts and lymphatic-system malformation. **Genetic basis** Yes **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Lymphatic malformation **Therapeutic area** Vascular Medicine ### Alternative names (4) - lymphatic malformation - hereditary lymphedema - Lymphatic Malformation, Low Flow - lymphedema, hereditary ## Clinical profile **Severity** Moderate ### Disease mechanisms (2) - Genetic - Hereditary Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019313) ### All therapeutic areas (4) - Cardiology - Hematology - Immunology - Vascular Medicine Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019313) ## Identifiers **MONDO ID** MONDO:0019313 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0019313) **Parent condition** MONDO:0003847 ## Related records ### Broader conditions (13) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - [Hereditary disease](https://trialight.com/data/condition/hereditary-disease-df2f8f05-e0c9-5777-8e51-c3b6639743d3.md) - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Lymphatic system disorder - Lymphedema - Lymphoid system disorder - Primary lymphedema - [Vascular disorder](https://trialight.com/data/condition/vascular-disorder-024125e7-3020-5357-8a27-46e6e1b8178a.md) ### Narrower conditions (47) - Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome - Campomelia, Cumming type - Congenital primary lymphedema of Gordon - Dahlberg-Borer-Newcomer syndrome - Deafness-lymphedema-leukemia syndrome - Hennekam lymphangiectasia-lymphedema syndrome 1 - Hennekam lymphangiectasia-lymphedema syndrome 2 - Hennekam lymphangiectasia-lymphedema syndrome 3 - Hennekam syndrome - Hypotrichosis-lymphedema-telangiectasia syndrome - Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome - Lymphatic malformation 1 - Lymphatic malformation 10 - Lymphatic malformation 11 - Lymphatic malformation 12 - Lymphatic malformation 13 - Lymphatic malformation 14 - Lymphatic malformation 2 - Lymphatic malformation 3 - Lymphatic malformation 4 ### Trials (42) - A Pharmacokinetic, Pharmacodynamic, Safety and Tolerability Study of CERC-006 in Adults With Complex Lymphatic Malformations - [A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)](https://trialight.com/data/trial/a-phase-2-study-of-mutant-selective-pi3k-inhibitor-rly-2608-cb48d7d4-b39e-48fc-b89b-e54745cb8b7c.md) - A Prospective Natural History Study of Lymphatic Anomalies - A Prospective Study on the Treatment of cLM Based on ICG Imaging - A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations - A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES Syndrome - A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations - Airway Vascular Lesions - Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation. - Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery - Bleomycin as an Effective and Curative Adjunct Therapy for Lymphangioma - Bleomycin Intralesional Injections of Cystic Hygromas - Clinical Characteristics of Lymphatic Malformations - Diagnosis of Hemangiomas and Vascular Malformations - Diagnostic Imaging of Vascular Malformations Using MSOT and ULM - Different Doses of Sirolimus for the Treatment of Cystic Lymphatic Malformations - Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations - European Registry Study on Lymphatic Interventions - First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations - Indocyanine Green Lymphography in Management of Lingual Lymphatic Malformation ### Drugs in development (7) - [Alpelisib](https://trialight.com/data/asset/alpelisib-0b0ae0f7-4313-42ef-bbbe-3280ed5ea15c.md) Phase 2 - Bleomycin Phase 2 - [Doxycycline](https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58.md) Phase 2 - OSI-027 Phase 1 - Selenium Phase 1 - Sildenafil Phase 2 - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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