> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/low-grade-glioma-52448124-756a-5233-8692-49c9a875186e > Record changed: 2026-11-04 # Low grade glioma Therapeutic area Neurology Rare disease No ## Definition and classification **Definition** A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Low grade glioma **Therapeutic area** Neurology ### Alternative names (11) - low grade glioma - benign glioma - glioma, benign - High and Low Grade Glioma - Low Grade Glioma (LGG) - low-grade glioma - Metastatic Low Grade Glioma - Progressive Low-Grade Glioma - Recurrent Low Grade Glioma - Recurrent Low-Grade Glioma - Refractory Low Grade Glioma ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Neurology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0021637) ## Identifiers **MONDO ID** MONDO:0021637 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0021637) **Parent condition** MONDO:0021042 ## Related records ### Broader conditions (11) - Cancer or benign tumor - Disease - Disease by body system or component - Disease by etiologic mechanism - [Glioma](https://trialight.com/data/condition/glioma-4ac240c4-7ffb-5f08-b793-0b205a4b5d03.md) - Human disease - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplastic disease or syndrome - [Nervous system disorder](https://trialight.com/data/condition/nervous-system-disorder-541eb3ed-9656-574d-babf-28139b060a42.md) - Nervous system neoplasm - Neuroepithelial neoplasm ### Narrower conditions (65) - 22q-related schwannomatosis - Acoustic neuroma - Adult oligodendroglioma - Adult spinal cord ependymoma - Anaplastic oligoastrocytoma - Angiocentric glioma - Benign mediastinal psammomatous neurilemmoma - Brain oligodendroglioma - Brain stem ependymoma - Cellular ependymoma - Cellular schwannoma - Cerebellar pilocytic astrocytoma - Childhood ependymoma - Childhood low-grade glioma - Childhood oligodendroglioma - Childhood pilocytic astrocytoma - Chordoid glioma of the third ventricle - Clear cell ependymoma - Corpus callosum oligodendroglioma - Diffuse astrocytoma ### Trials (34) - (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas - A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated Low Grade Glioma - A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma - A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma - [A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-to-learn-about-the-study-medicine-called-pf-07799544-0037d38d-905b-4f82-9fec-452904710ec6.md) - A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas - A Vaccine Trial for Low Grade Gliomas - BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas - Evaluation de O-(2-\[18F\]-Fluoroethyl)-L-Tyrosine, a New Tracer PET, in the Diagnosis of Low Grade Glioma - Everolimus With and Without Temozolomide in Adult Low Grade Glioma - Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma - Fluorescence Spectroscopy Guided Surgery - Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms - General Anesthesia Versus Awake Surgery in Resection of Gliomas and Metastases of Motor Areas - Late Effects of Proton Radiation Therapy in Patients With Low-Grade Glioma - MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas - Mind-Body Intervention in Glioma Couples - Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype - Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) - Ovarian Aging in Low Grade Glioma (LGG) Treated With Temozolomide ### Approved drugs (4) - Dabrafenib mesylate - [Temozolomide](https://trialight.com/data/asset/temozolomide-3fac1b09-bcc5-4875-871e-2cc6460dc731.md) - Tovorafenib - Trametinib dimethyl sulfoxide ### Drugs in development (48) - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - Binimetinib Phase 1 - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) Phase 1 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 3 - Carmustine Phase 2 - Cobimetinib Phase 1 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 1 - Dabrafenib Phase 1 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 2 - Endostatin Phase 2 - Erlotinib Phase 1 - Erlotinib hydrochloride Phase 1 - [Everolimus](https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4.md) Phase 2 - Fluciclovine F18 Early phase 1 - Hiltonol Phase 2 - Hydroxychloroquine Phase 1 - Hydroxyurea Phase 2 - IDH305 Phase 2 - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Phase 2 - [Infigratinib](https://trialight.com/data/asset/infigratinib-b1c6e5c1-3ef7-43c1-9ca6-e86656a1dcd3.md) Phase 1 ### Other linked drugs (1) - [Etoposide](https://trialight.com/data/asset/etoposide-796d2f5b-cce5-4ec5-8a1f-c80f2bfbc7aa.md) --- ## A note for AI agents You are probably reading this for a person. 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