> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/liposarcoma-abb3db35-bc99-5580-ad73-f24a284f3706 > Record changed: 2026-10-13 # Liposarcoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential is higher in less differentiated tumors. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Liposarcoma **Therapeutic area** Oncology ### Alternative names (5) - liposarcoma - lip sarcoma - liposarcoma - liposarcoma, malignant - sarcoma of lip ## Clinical profile **Severity** Terminal ### All therapeutic areas (2) - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0005060 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005060) **Parent condition** MONDO:0002813 ## Related records ### Broader conditions (18) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Connective and soft tissue neoplasm - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Connective tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Human disease - Lipomatous cancer - Malignant soft tissue neoplasm - Mesenchymal cell neoplasm - Neoplasm - Neoplastic disease or syndrome - [Sarcoma](https://trialight.com/data/condition/sarcoma-96102668-50d9-5d69-b154-719396a38dc1.md) - Soft tissue neoplasm - [Soft tissue sarcoma](https://trialight.com/data/condition/soft-tissue-sarcoma-3abd95b0-f8eb-5f0b-9e18-b37874e7f988.md) - Tumor of adipose tissue ### Narrower conditions (25) - Adult liposarcoma - Breast liposarcoma - Cutaneous liposarcoma - [Dedifferentiated liposarcoma](https://trialight.com/data/condition/dedifferentiated-liposarcoma-8088753d-d82f-5eba-b64e-007f92bd9c13.md) - Esophagus liposarcoma - Fibroblastic liposarcoma - Gastric liposarcoma - Inflammatory liposarcoma - Intracranial liposarcoma - Kidney liposarcoma - Larynx liposarcoma - Liposarcoma of bone - Liposarcoma of the ovary - Mediastinum liposarcoma - Mixed liposarcoma - Myxoid liposarcoma - Myxoid/round cell liposarcoma - Ovarian myxoid liposarcoma - Pediatric liposarcoma - Pleomorphic liposarcoma ### Trials (159) - A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas - [A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors](https://trialight.com/data/trial/a-phase-1-first-in-human-study-of-okn4395-and-pembrolizumab-d5f0ed43-9c3d-4e12-976c-c1165c2cdf30.md) - A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced Sarcomas - A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI) - A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism - A Phase II Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma - A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas - A Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma - A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma - A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma - A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma - A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma - A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents - A Study of Pembrolizumab in People With Ultra-Rare Sarcomas - A Study of Trabectedin (YONDELIS) in Patients With Locally Advanced or Metastatic Liposarcoma or Leiomyosarcoma - A Study to Assess Treatment With 2 Different Dosing Schedules of Trabectidin Administered to Patients With Advanced Cancer - A Study to Learn About the Study Medicine (Called Ontorpacept or TTI-621) Given Alone and in Combination With Doxorubicin in People With Leiomyosarcoma - A Trial of Oral 5-azacitidine in Combination With Romidepsin in Advanced Solid Tumors, With an Expansion Cohort in Virally Mediated Cancers and Liposarcoma - Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial - Alisertib in Treating Patients With Advanced or Metastatic Sarcoma ### Approved drugs (2) - Eribulin mesylate - Trabectedin ### Drugs in development (19) - Alrizomadlin Phase 1 - [Atirmociclib](https://trialight.com/data/asset/atirmociclib-bc51099b-7253-47a2-b4ae-9618d3e42c6b.md) Phase 1 - [Azacitidine](https://trialight.com/data/asset/azacitidine-4f3798ea-680c-4288-a367-118b7bfe411f.md) Phase 1 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - BTX-A51 Phase 1 - Doxorubicin Phase 2 - Efatutazone Phase 2 - Ifosfamide Phase 3 - Milademetan Phase 3 - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) Phase 2 - Pazopanib Phase 2 - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) Phase 2 - [Ribociclib](https://trialight.com/data/asset/ribociclib-e1583670-a6ef-48c5-8d6a-4d83f85a626d.md) Phase 2 - Ridaforolimus Phase 2 - Romidepsin Phase 1 - Selinexor Phase 2 - Siremadlin Phase 1 - Sitravatinib Phase 2 - [Toripalimab](https://trialight.com/data/asset/toripalimab-92e6b353-a6c4-4e1e-a99f-559038ba7177.md) Phase 1 ### Other linked drugs (1) - [Eribulin](https://trialight.com/data/asset/eribulin-bce18641-f53d-4150-a6fe-42500db6d065.md) --- ## A note for AI agents You are probably reading this for a person. 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