> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/leiomyosarcoma-d667e691-607d-538f-9036-4dbc7ebef160 > Record changed: 2026-10-13 # Leiomyosarcoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Leiomyosarcoma **Therapeutic area** Oncology ### Alternative names (6) - leiomyosarcoma - Leiomyosarcomas - leiomyosarcoma - leiomyosarcoma (excluding uterine leiomyosarcoma) - leiomyosarcoma - not uterine - leiomyosarcoma, malignant ## Clinical profile **Disease mechanisms** - Acquired **Severity** Severe ### All therapeutic areas (3) - Neuromuscular Disease - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0005058 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005058) **Parent condition** MONDO:0002924 ## Related records ### Broader conditions (27) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Connective and soft tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Epstein-Barr virus-associated mesenchymal tumor - Epstein-Barr virus-related tumor - Human disease - Malignant soft tissue neoplasm - Mesenchymal cell neoplasm - Muscle cancer - Muscle tissue disorder - Musculoskeletal system cancer - Musculoskeletal system disorder - Myomatous neoplasm - Neoplasm - Neoplastic disease or syndrome - Post-infectious disorder ### Narrower conditions (36) - Anus leiomyosarcoma - Bone leiomyosarcoma - Breast leiomyosarcoma - Central nervous system leiomyosarcoma - Colon leiomyosarcoma - Conventional leiomyosarcoma - Cutaneous leiomyosarcoma - Epithelioid leiomyosarcoma - Esophagus leiomyosarcoma - Extrahepatic bile duct leiomyosarcoma - Fallopian tube leiomyosarcoma - Gallbladder leiomyosarcoma - Gastric leiomyosarcoma - Granular cell leiomyosarcoma - Heart leiomyosarcoma - Inflammatory leiomyosarcoma - Kidney leiomyosarcoma - Laryngeal leiomyosarcoma - Leiomyosarcoma of the cervix uteri - Leiomyosarcoma of the corpus uteri ### Trials (163) - A Five-Tier, Open-Label Study of IMC-A12 in Advanced Sarcoma - [A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors](https://trialight.com/data/trial/a-phase-1-first-in-human-study-of-okn4395-and-pembrolizumab-d5f0ed43-9c3d-4e12-976c-c1165c2cdf30.md) - A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic Therapy - A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced Sarcomas - A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions - A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas - A Study of Different Dosing Schedules of Selinexor in Sarcoma Patients - A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma - A Study of Ivonescimab in People With Leiomyosarcoma - A Study of LY3435151 in Participants With Solid Tumors - A Study of Nivolumab in Selected Uterine Cancer Patients - A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents - A Study of Rucaparib and Nivolumab in People With Leiomyosarcoma - A Study of Trabectedin (YONDELIS) in Patients With Locally Advanced or Metastatic Liposarcoma or Leiomyosarcoma - A Study of Trabectedin or Dacarbazine for the Treatment of Patients With Advanced Liposarcoma or Leiomyosarcoma - A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS) - A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS) - A Study to Assess Treatment With 2 Different Dosing Schedules of Trabectidin Administered to Patients With Advanced Cancer - A Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes - A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases ### Approved drugs (1) - Trabectedin ### Drugs in development (29) - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Phase 2 - Berzosertib Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 2 - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Phase 3 - Dacarbazine Phase 3 - Dinutuximab Phase 2 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 2 - Doxorubicin Phase 3 - [Doxorubicin hydrochloride](https://trialight.com/data/asset/doxorubicin-hydrochloride-2e3493ba-9766-475e-aa7d-f2debf111de5.md) Phase 3 - Gadolinium Phase 2 - [Gemcitabine](https://trialight.com/data/asset/gemcitabine-40c84c8f-1f08-4402-bce9-f31ff283382e.md) Phase 2 - Ifosfamide Phase 3 - [Ipilimumab](https://trialight.com/data/asset/ipilimumab-06c42b29-e333-4f3c-94fe-dbea5fe48cd4.md) Phase 2 - [Letrozole](https://trialight.com/data/asset/letrozole-67319198-7e88-4130-b185-d776c835863c.md) Phase 2 - Lurbinectedin Phase 2 - Mocetinostat Phase 2 - Nedisertib Phase 1 - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) Phase 2 - [Olaparib](https://trialight.com/data/asset/olaparib-3421b73f-1a4f-4337-b6f3-de5feeb57108.md) Phase 2 ### Other linked drugs (1) - Epirubicin --- ## A note for AI agents You are probably reading this for a person. 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