> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/irritable-bowel-syndrome-10830a51-118b-59c5-8ff4-5e11dbe81c01 > Record changed: 2026-10-13 # Irritable bowel syndrome Therapeutic area Gastroenterology Rare disease No ## Definition and classification **Definition** Irritable bowel syndrome (IBS) is a chronic functional condition of the lower gastrointestinal (GI) tract characterized by abdominal pain or discomfort and disordered bowel habit (diarrhea, constipation, or fluctuation between the two). **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Irritable bowel syndrome **Therapeutic area** Gastroenterology ### Alternative names (6) - irritable bowel syndrome - IBS - irritable bowel syndrome - irritable colon - mucus colitis - spastic colon ## Clinical profile **Disease mechanisms** - Syndromic **All therapeutic areas** - Gastroenterology **Severity** Mild ## Identifiers **MONDO ID** MONDO:0005052 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005052) **Parent condition** MONDO:0002254 ## Related records ### Broader conditions (6) - [Digestive system disorder](https://trialight.com/data/condition/digestive-system-disorder-ae55641c-32fa-5aa9-ab90-29f763a95dc0.md) - Disease - Disease by body system or component - Human disease - Intestinal disorder - Syndromic disease ### Trials (1,008) - "Efficacy and Safety of Linaclotide in Chronic Constipation" - "Functional Bowel Disorder. Investigation in General Practice" - (FODMAP) Diet on Improving Symptoms of Patients With Irritable Bowel Syndrome - 12-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D) - 12-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D) - 1H-19F Gastrointestinal MRI in Health and IBS - 24 Hrs Histamine Profile in Healthy Persons and Patients With Food Intolerance - 25-hydroxyvitamin D and Fatigue: The VITALITY Study - 52-Week Efficacy and Safety Study of Ibodutant in Women With Irritable Bowel Syndrome With Diarrhea (IBS-D) - 8 Weeks Treatment With DDP225 in Patients With Diarrhea Predominant IBS - A 14-week Pilot Prospective Clinical Trial With BiOkuris Product in Patients With Irritable Bowel Syndrome - A Clinical Study to Determine the Safety and Efficacy of An Oral Probiotic Supplementation in the Management of Irritable Bowel Syndrome With Protein Digestion. - A Clinical Trial Evaluating Diets for IBS - A Comparison of the Effects of ORP-101 Versus Placebo in Adult Patients With Irritable Bowel Syndrome With Diarrhea (IBS-D) - A Comparison of Three Different Treatment Options for Irritable Bowel Syndrome - A Computer-Based Intervention for Medically Unexplained Physical Symptoms - A Cross-sectional Study on IBS Subtypes, Chinese Medicine Pattern and Host-gut Microbiota Metabolic Interactions - A Flexible Clinical Trial to Test if Freeze-dried Fecal Microbiota Therapy Helps Treat Diarrhea-predominant Irritable Bowel Syndrome or Prevent Recurring C. Difficile Infections. - A Four Arm Study to Evaluate the Safety and Efficacy of 3 Different Doses of RVX-100 Versus Placebo in Subjects With Irritable Bowel Syndrome Accompanied by Diarrhea (IBS-D) - A Lactation Study in Women Who Are Breastfeeding or Pumping and Are Receiving Linaclotide Therapeutically ### Approved drugs (8) - Alosetron hydrochloride - [Clindamycin phosphate](https://trialight.com/data/asset/clindamycin-phosphate-419e01e3-b65c-4586-a4bd-e2ef6ecfc03b.md) - Dicyclomine hydrochloride - Eluxadoline - Linaclotide - Lubiprostone - Tegaserod maleate - Tenapanor hydrochloride ### Drugs in development (80) - Acetylcysteine Phase 1 - Alosetron Phase 3 - Anise oil Phase 3 - Asimadoline Phase 3 - Bifidobacterium SPP. Phase 3 - BOS-589 Phase 2 - [Charcoal, activated](https://trialight.com/data/asset/charcoal-activated-74974a11-0327-42be-ba92-123123e02c3a.md) Phase 2 - Chenodiol Phase 2 - [Cholecalciferol](https://trialight.com/data/asset/cholecalciferol-c9dc6a9a-8bc7-4070-a34e-535013073648.md) Phase 1 - Cilansetron Phase 3 - Citalopram Phase 2 - Crofelemer Phase 2 - DA-6886 Phase 1 - DDP-225 Phase 2 - Dexloxiglumide Phase 3 - Dextofisopam Phase 2 - Dextromethorphan Phase 2 - DNK333 Phase 2 - Doxepin Phase 2 - [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md) Phase 2 ### Other linked drugs (11) - Amitriptyline - Clidinium - Desipramine - Drotaverine - Esketamine - Methantheline - Ornidazole - Oxitriptan - Prifinium - Sulfasalazine - Tegaserod --- ## A note for AI agents You are probably reading this for a person. 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