> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/infectious-otitis-media-f40bd52c-06fc-5246-993c-86e35f6a6c07 > Record changed: 2026-11-04 # Infectious otitis media Therapeutic area Infectious Disease Rare disease No ## Definition and classification **Definition** Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Infectious otitis media **Therapeutic area** Infectious Disease ### Alternative names (9) - infectious otitis media - acute otitis Media - Acute Otitis Media (AOM) - AOM - middle Ear infection - Middle Ear Infections - Nasopharyngeal Colonization and Acute Otitis Media - Recurrent Acute Otitis Media - otitis media ## Clinical profile **Severity** Mild ### Disease mechanisms (2) - Acquired - Inflammatory Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0024330) ### All therapeutic areas (2) - Infectious Disease - Otology/Audiology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0024330) ## Identifiers **MONDO ID** MONDO:0024330 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0024330) **Parent condition** MONDO:0005441 ## Related records ### Broader conditions (14) - Auditory system disorder - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Disorder of ear - Ear infection - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Inflammatory disease - Middle ear disorder - [Otitis media](https://trialight.com/data/condition/otitis-media-aa1c6944-b9f6-58dc-8e64-6624ba1f0d76.md) - Otorhinolaryngologic disease ### Trials (84) - A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media - A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media - A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea - A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes - A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children - A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections - A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months - A Trial of Point of Care Information in Ambulatory Pediatrics - Acute Otitis Media (AOM) Therapy Trial in Young Children - Amoxicillin Clavulanate in Treatment of Acute Otitis Media - Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children - An Epidemiological Survey to Establish the Spectrum of Circulating Serotypes of S. Pneumoniae, in Patients Older 18 Years - Analgesic Ear Drops for Children With Acute Otitis Media - Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus - Artificial Intelligence Diagnostic Decision Support to Reduce Antimicrobial Prescriptions in Young Children With Colds - Assessment of the Natural Antibody Response to Pneumococcal Surface Proteins During Acute Otitis Media in Children - Bio-Kult Infantis® in AAD Prevention in Infants - Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients - Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) - Comparative Effectiveness of Antibiotics for Respiratory Infections ### Approved drugs (4) - [Amoxicillin](https://trialight.com/data/asset/amoxicillin-09050e6a-69b4-42d1-b3eb-79212edcf388.md) - Azithromycin - Cefdinir - Clavulanate potassium ### Drugs in development (13) - Antipyrine Phase 2 - Azithromycin monohydrate Phase 3 - Benzocaine Phase 3 - [Ciprofloxacin](https://trialight.com/data/asset/ciprofloxacin-8dbb4fad-883a-4e58-8501-5887c084b0ef.md) Phase 3 - [Clavulanic acid](https://trialight.com/data/asset/clavulanic-acid-465f3e04-3ad5-4ece-97cf-d63cae081959.md) Phase 3 - Colfosceril palmitate Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 3 - Finafloxacin Phase 2 - Glycerin Phase 3 - [Moxifloxacin](https://trialight.com/data/asset/moxifloxacin-17fc41bd-6b29-4dda-a755-554e6ce94ccc.md) Phase 3 - Ofloxacin Phase 3 - Syrup Phase 3 - Xylitol Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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