> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/in-situ-carcinoma-0ae6941f-ec23-5c3a-9391-0bb8b12ff6ad > Record changed: 2026-10-13 # in situ carcinoma Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A malignant epithelial neoplasm which is confined to the epithelial layer without evidence of further tissue invasion. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** in situ carcinoma **Therapeutic area** Oncology ### Alternative names (8) - in situ carcinoma - CIS - carcinoma in situ - carcinoma, in situ, malignant - epithelial tumor, in situ, malignant - intraepithelial carcinoma - non-invasive carcinoma - stage 0 disease ## Clinical profile **All therapeutic areas** - Oncology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0004647 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004647) **Parent condition** MONDO:0004993 ## Related records ### Broader conditions (11) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - High grade malignant neoplasm - Human disease - Neoplasm - Neoplastic disease or syndrome - Precancerous condition ### Narrower conditions (52) - Adenocarcinoma in situ - Anal canal carcinoma in situ - Atypical lobular breast hyperplasia - Bile duct carcinoma in situ - Bladder carcinoma in situ - Bowen disease of the skin - Breast apocrine carcinoma in situ - Breast carcinoma in situ - Bronchus carcinoma in situ - Carcinoma in situ of appendix - Carcinoma in situ of cecum - Carcinoma in situ of epiglottis - Carcinoma in situ of extrahepatic bile duct - Carcinoma in situ of fundus of stomach - Carcinoma in situ of gastric body - Carcinoma in situ of gastric cardia - Carcinoma in situ of hypopharynx - Carcinoma in situ of nasopharynx - Carcinoma in situ of oropharynx - Carcinoma in situ of renal pelvis ### Trials (81) - [A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)](https://trialight.com/data/trial/a-clinical-study-of-intismeran-autogene-v940-and-bcg-in-c5ae0ff1-1e9f-48d0-8c2e-0fcd92456beb.md) - [A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.](https://trialight.com/data/trial/a-dose-escalation-and-dose-expansion-study-of-intratumoral-7ff04566-d63e-405b-be58-a6b39637fe93.md) - A Prospective Registry to Assess the Effectiveness and Local Tolerability of Intravesical Valrubicin in Subjects With Non-muscle Invasive Bladder Cancer (NMIBC) - A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancer - A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder Cancer (NMIBC) - A Study of Stimulator of Interferon Genes (STING) Agonist E7766 in Non-muscle Invasive Bladder Cancer (NMIBC) Including Participants Unresponsive to Bacillus Calmette-Guerin (BCG) Therapy, INPUT-102 - A Trial to Evaluate Efficacy of Reinduction With Nadofaragene Firadenovec in Subjects With CIS ± High-grade Ta/T1 and no Complete Response to First Nadofaragene Firadenovec Dose. - Broccoli Sprout Extract in Preventing Recurrence in Patients With Tobacco-Related Head and Neck Squamous Cell Cancer - Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases - Cervical And Self-Sample In Screening Study - Chromoscopic Guided Endomicroscpy to Diagnose Colitis Associated Dysplasia - Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention - Colposcopy in Detection of Oral Epithelial Dysplasia - Comparison of pCLE and EB in Gastric Lesion Diagnosis - Difference of Gastric Microbiota in the Process of Correa's Model. - Dose-Escalation Study of CG0070 for Bladder Cancer After BCG (Bacillus Calmette-Guerin) Failure - Durvalumab and Vicineum in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Guerin (BCG) - E7 TCR T Cells for Human Papillomavirus-Associated Cancers - Early Detection of High Grade Ovarian Cancer Using Uterine Lavage EHUD Study and Duplex Sequencing - Effectiveness of Cervical Screening in Unvaccinated, Herd Effect Protected Women (HPV400) ### Drugs in development (4) - Aminolevulinic acid hydrochloride Phase 1 - [Cholecalciferol](https://trialight.com/data/asset/cholecalciferol-c9dc6a9a-8bc7-4070-a34e-535013073648.md) Phase 1 - Mitomycin Phase 3 - Valrubicin Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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