> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8 > Record changed: 2026-10-13 # Immune system disorder Therapeutic area Immunology Rare disease No ## Definition and classification **Definition** A disorder resulting from an abnormality in the immune system. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Immune system disorder **Therapeutic area** Immunology ### Alternative names (9) - immune system disorder - disease of immune system - disease or disorder of immune system - disorder of immune system - immune disease - immune disorder - immune dysfunction - immune system disease or disorder - immune system disorder ## Clinical profile **All therapeutic areas** - Immunology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0005046 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005046) **Parent condition** MONDO:7770006 ## Related records ### Broader conditions (3) - Disease - Disease by body system or component - Human disease ### Narrower conditions (1,579) - 2-hydroxyethyl methacrylate sensitization - 22q11.2 deletion syndrome - A20 haploinsufficiency - A53 diffuse large B-cell lymphoma - Aagenaes syndrome - Abdominal cystic lymphangioma - AChR+ myasthenia gravis - Acid sphingomyelinase deficiency - Acquired adult-onset immunodeficiency - Acquired agranulocytosis - Acquired epidermolysis bullosa - Acquired hemophagocytic lymphohistiocytosis associated with malignant disease - [Acquired immunodeficiency](https://trialight.com/data/condition/acquired-immunodeficiency-cb923b76-5f0c-526b-9336-3ed143e5b2cb.md) - Acquired polycythemia - [Acquired polycythemia vera](https://trialight.com/data/condition/acquired-polycythemia-vera-5c3132a8-49a0-5b93-b3d6-cd5f1fa9e10e.md) - Acquired secondary polycythemia - Acquired thrombotic thrombocytopenic purpura - Activated PI3K-delta syndrome - Acute allergic serous otitis media - Acute basophilic leukemia ### Trials (476) - (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis - (Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis - 24-Week Induction Study of APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE 3) - A Clinical Study of ONCT-808 in Subjects With Relapsed or Refractory B-Cell Malignancies - A Clinical Trial for Evaluation of Efficacy, Safety and Immunogenicity of GNR-127 (Recombinant ABP Antigen Protein Which Carries a Birch Pollen Allergen \[BET V 1\] and an Apple Allergen \[MAL D 1\]) in Patients With Birch Pollen Allergic Rhinitis. - A Clinical Trial to Evaluate the Safety and Immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39.3 gp151 CD4KO HIV Trimer mRNA Vaccines in Healthy, HIV-uninfected Adult Participants - A Dose Escalation Trial of Safety, Pharmacokinetic/Pharmacodynamic and Preliminary Clinical Activity of Briquilimab in Adult Patients With Chronic Inducible Urticaria (CIndU) Who Remain Symptomatic Despite Treatment With H1- Antihistamines - A Dose Finding Study to Investigate the Safety and Effectiveness of GSK1070806 in Adult Participants With Moderate to Severe Atopic Dermatitis - A Double-blind Randomized Controlled Trial of a Thickened Amino-acid-based Formula in Children Allergic to Cow's Milk and to Protein Hydrolysates - A Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Safety and Efficacy of Briquilimab in Participants With Allergic Asthma - A First-in-Human Phase I Trial of OX118 in Healthy Volunteers - A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma - A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia - A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells \[DSG3-CAART\] or CD19-specific Chimeric Antigen Receptor T Cells \[CABA-201\]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV) - A Phase 2 Study to Evaluate the Safety and Efficacy of LOU064 in Patients With Moderate to Severe Sjögren's Syndrome - A Phase I Extension Trial of Repeated Infusions of ISF35 - A Phase I Trial of Autologous CLL B Cells Transduced to Express Chimeric CD154 (ISF35) - A Phase Ib Study of ISF35 in Combination With Chemotherapy (FCR) in Subjects With Relapsed, Refractory, and/or 17p- CLL - A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes - A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus ### Approved drugs (47) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) - Alefacept - Amifampridine phosphate - [Anakinra](https://trialight.com/data/asset/anakinra-2c0352ee-cb20-46c5-bd87-6350d9024e75.md) - [Apremilast](https://trialight.com/data/asset/apremilast-41723353-24b2-46d5-82cf-9e6280b6f765.md) - Azathioprine - Basiliximab - [Belatacept](https://trialight.com/data/asset/belatacept-8e93aa79-7b65-4b31-b315-47488d14be9d.md) - Belumosudil - [Bimekizumab](https://trialight.com/data/asset/bimekizumab-74957cc7-f3d4-4173-babe-0de5e90fd2dd.md) - Brodalumab - [Canakinumab](https://trialight.com/data/asset/canakinumab-7cd74b21-082d-4a09-8847-aa6d401bc853.md) - Certolizumab pegol - Cladribine - Cyclosporine - Daclizumab - Darvadstrocel - Dimethyl fumarate - Diroximel fumarate ### Drugs in development (63) - Abetimus Phase 2 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 1 - Afelimomab Phase 2 - Alemtuzumab Phase 2 - [Amlitelimab](https://trialight.com/data/asset/amlitelimab-5868499c-5856-412c-a1ca-a09f41940c70.md) Phase 1 - Anisperimus Phase 2 - Antilymphocyte immunoglobulin (horse) Phase 2 - Azithromycin Phase 1 - Belantamab Phase 1 - Brepocitinib Phase 1 - Brepocitinib tosylate Phase 1 - Briakinumab Phase 3 - Busulfan Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 2 - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) Phase 1 - [Deucravacitinib](https://trialight.com/data/asset/deucravacitinib-3033fa9d-d652-4397-81c1-5e76480167af.md) Phase 1 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 2 - Diphenhydramine Phase 1 - Disermolide Phase 1 - Eculizumab Phase 2 ### Other linked drugs (11) - Actarit - Amifampridine - Bucillamine - CDP-484 - Gusperimus trihydrochloride - Hydroxychloroquine - [Meropenem](https://trialight.com/data/asset/meropenem-a90880e5-37b0-473b-bf12-d5f0de7894c2.md) - Napirimus - Pegademase bovine - Thymopentin - Varicella zoster virus, live attenuated --- ## A note for AI agents You are probably reading this for a person. 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