> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/hypertrophic-cardiomyopathy-2bcaf1dc-551c-50d7-8f5b-4b8457815d3c > Record changed: 2026-10-13 # Hypertrophic cardiomyopathy Therapeutic area Cardiology Rare disease Yes ## Definition and classification **Definition** A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Hypertrophic cardiomyopathy **Therapeutic area** Cardiology ### Alternative names (5) - hypertrophic cardiomyopathy - hypertrophic cardiomyopathy - hypertrophic subaortic stenosis - obstructive hypertrophic cardiomyopathy - familial hypertrophic cardiomyopathy ## Clinical profile **Severity** Severe ### All therapeutic areas (3) - Cardiology - Neuromuscular Disease - Rheumatology ## Identifiers **MONDO ID** MONDO:0005045 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005045) **Parent condition** MONDO:0000591 ## Related records ### Broader conditions (9) - [Cardiomyopathy](https://trialight.com/data/condition/cardiomyopathy-f867c8a5-a3a9-513d-a7ca-7e2d05ad56d3.md) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Disease - Disease by body system or component - Heart disorder - Human disease - Intrinsic cardiomyopathy - Muscle tissue disorder - Musculoskeletal system disorder ### Narrower conditions (103) - 46,XY complete gonadal dysgenesis - 46,XY disorder of sex development due to testicular 17,20-desmolase deficiency - 46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome - 46,XY sex reversal 1 - 46,XY sex reversal 10 - 46,XY sex reversal 11 - 46,XY sex reversal 2 - 46,XY sex reversal 3 - 46,XY sex reversal 4 - 46,XY sex reversal 5 - 46,XY sex reversal 6 - 46,XY sex reversal 7 - 46,XY sex reversal 9 - AL amyloidosis - Beckwith-Wiedemann syndrome - Beckwith-Wiedemann syndrome due to 11p15 microdeletion - Beckwith-Wiedemann syndrome due to 11p15 microduplication - Beckwith-Wiedemann syndrome due to 11p15 translocation/inversion - Beckwith-Wiedemann syndrome due to CDKN1C mutation - Beckwith-Wiedemann syndrome due to imprinting defect of 11p15 ### Trials (344) - 3D Non-invasive Myocardial Electrical Propagation Mapping as a New Tool to Predict Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy - 4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy - A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease - A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy - A Cardiac Disease Quality of Life Study - [A Clinical Study to Evaluate the Long-term Safety of HRS-1893 in Hypertrophic Cardiomyopathy](https://trialight.com/data/trial/a-clinical-study-to-evaluate-the-long-term-safety-of-hrs-9f6191c7-54bf-40c6-9199-501244b86f1e.md) - A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy - A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease - A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM - A Noninterventional, Single-Center Feasibility Study to Evaluate Measures of Heart Failure Risk - A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction - A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CT-G20 in Subjects With Obstructive Hypertrophic Cardiomyopathy - A Phase III Trial of HRS-1893 in Patients With Obstructive Hypertrophic Cardiomyopathy - A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare - A Prospective Incident Study of Arrhythmias in Hypertrophic Cardiomyopathy - A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) - A Real-world HCM-cohort Trial - A Real-World Study on Hypertrophic Cardiomyopathy in Chinese Population - A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada - A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects ### Approved drugs (1) - [Mavacamten](https://trialight.com/data/asset/mavacamten-71ab9bd6-4d0a-448d-a680-fb7603992b64.md) ### Drugs in development (21) - Acetylcysteine Phase 1 - Aficamten Phase 3 - [Amlodipine](https://trialight.com/data/asset/amlodipine-b06f8f1a-f55d-4a6b-b513-c6443387d4ae.md) Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 3 - Atorvastatin Phase 3 - Candesartan Phase 2 - [Delocamten](https://trialight.com/data/asset/delocamten-b77478b2-dc82-4859-87bc-1d64bb047d7f.md) Phase 2 - Diltiazem Phase 2 - Eleclazine Phase 2 - Losartan Phase 2 - Metoprolol succinate Phase 3 - Ninerafaxstat Phase 2 - Perhexiline Phase 3 - [Pirfenidone](https://trialight.com/data/asset/pirfenidone-3eaa7241-8908-43a6-9121-310e804c1fcc.md) Phase 2 - [Rivaroxaban](https://trialight.com/data/asset/rivaroxaban-3f354e10-6d35-4989-9e00-318be65808fb.md) Phase 3 - [Sacubitril](https://trialight.com/data/asset/sacubitril-f4195200-c5a2-450f-b0dd-5f61db1ee02a.md) Phase 2 - Sodium nitrate Phase 1 - Sotagliflozin Phase 3 - Trientine Phase 2 - Trimetazidine Phase 2 ### Other linked drugs (1) - Henagliflozin --- ## A note for AI agents You are probably reading this for a person. 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