Hypertrophic cardiomyopathy
Therapeutic area
Cardiology
Rare disease
Yes
- Definition
- A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Hypertrophic cardiomyopathy
- Therapeutic area
- Cardiology
- hypertrophic cardiomyopathy
- hypertrophic cardiomyopathy
- hypertrophic subaortic stenosis
- obstructive hypertrophic cardiomyopathy
- familial hypertrophic cardiomyopathy
- Severity
- Severe
- Cardiology
- Neuromuscular Disease
- Rheumatology
- MONDO ID
- MONDO:0005045
- Parent condition
- MONDO:0000591
Related records
Broader conditions (9)
- Cardiomyopathy
- Cardiovascular disorder
- Disease
- Disease by body system or component
- Heart disorder
- Human disease
- Intrinsic cardiomyopathy
- Muscle tissue disorder
- Musculoskeletal system disorder
Narrower conditions (103)
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- 46,XY sex reversal 1
- 46,XY sex reversal 10
- 46,XY sex reversal 11
- 46,XY sex reversal 2
- 46,XY sex reversal 3
- 46,XY sex reversal 4
- 46,XY sex reversal 5
- 46,XY sex reversal 6
- 46,XY sex reversal 7
- 46,XY sex reversal 9
- AL amyloidosis
- Beckwith-Wiedemann syndrome
- Beckwith-Wiedemann syndrome due to 11p15 microdeletion
- Beckwith-Wiedemann syndrome due to 11p15 microduplication
- Beckwith-Wiedemann syndrome due to 11p15 translocation/inversion
- Beckwith-Wiedemann syndrome due to CDKN1C mutation
- Beckwith-Wiedemann syndrome due to imprinting defect of 11p15
Trials (344)
- 3D Non-invasive Myocardial Electrical Propagation Mapping as a New Tool to Predict Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy
- 4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy
- A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
- A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy
- A Cardiac Disease Quality of Life Study
- A Clinical Study to Evaluate the Long-term Safety of HRS-1893 in Hypertrophic Cardiomyopathy
- A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy
- A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease
- A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM
- A Noninterventional, Single-Center Feasibility Study to Evaluate Measures of Heart Failure Risk
- A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction
- A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CT-G20 in Subjects With Obstructive Hypertrophic Cardiomyopathy
- A Phase III Trial of HRS-1893 in Patients With Obstructive Hypertrophic Cardiomyopathy
- A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare
- A Prospective Incident Study of Arrhythmias in Hypertrophic Cardiomyopathy
- A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
- A Real-world HCM-cohort Trial
- A Real-World Study on Hypertrophic Cardiomyopathy in Chinese Population
- A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada
- A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects
Approved drugs (1)
Drugs in development (21)
- Acetylcysteine Phase 1
- Aficamten Phase 3
- Amlodipine Phase 2
- Aspirin Phase 3
- Atorvastatin Phase 3
- Candesartan Phase 2
- Delocamten Phase 2
- Diltiazem Phase 2
- Eleclazine Phase 2
- Losartan Phase 2
- Metoprolol succinate Phase 3
- Ninerafaxstat Phase 2
- Perhexiline Phase 3
- Pirfenidone Phase 2
- Rivaroxaban Phase 3
- Sacubitril Phase 2
- Sodium nitrate Phase 1
- Sotagliflozin Phase 3
- Trientine Phase 2
- Trimetazidine Phase 2
Other linked drugs (1)
- Henagliflozin