> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/huntington-disease-fe2d46ec-080a-5259-a901-cad1d6e07061 > Record changed: 2026-10-13 # Huntington disease Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Huntington disease **Therapeutic area** Neurology ### Alternative names (7) - Huntington disease - HD - Huntington chorea - Huntington disease - Huntington's Disease - Huntington's chorea - Huntington's disease ## Clinical profile **All therapeutic areas** - Neurology **Severity** Severe ### Disease mechanisms (2) - Genetic - Hereditary ## Identifiers **MONDO ID** MONDO:0007739 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007739) **Parent condition** MONDO:0000167 ## Related records ### Broader conditions (13) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Hereditary disease - Hereditary neurological disease - Human disease - Huntington disease and related disorders - Inherited neurodegenerative disorder - [Movement disorder](https://trialight.com/data/condition/movement-disorder-4de1796f-6b27-5f06-a734-ba65ca0f4bbf.md) - Nervous system disorder - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) ### Narrower conditions (2) - Juvenile Huntington disease - Westphal disease ### Trials (297) - \[PETDE10\] Imaging of PDE10A Enzyme Levels in Huntington's Disease Gene Expansion Carriers and Healthy Controls With PET. - 28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease - 31P-MRS and Huntington Disease - A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery - A Clinical Study in Participants With Huntington's Disease (HD) to Assess Efficacy and Safety of Three Oral Doses of Laquinimod - A Comparative Phase 2 Study Assessing the Efficacy of Triheptanoin, an Anaplerotic Therapy in Huntington's Disease - A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease - A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects - A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease - A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease - A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions - A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan - A Phase 1 Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon \[PF-01913539\] In Japanese And Western Healthy Subjects - A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon \[PF 01913539\] In Subjects With Severely-Impaired And Normal Renal Function - A Phase 1, Randomized, Open-Label, Two-Way Crossover Study To Evaluate The Steady-State Effect Of Dimebon (PF 01913539) On The Single-Dose Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects - A Phase 2, to Evaluating the Safety and Efficacy of Pridopidine Vs Placebo for Symptomatic Treatment in Patients With Huntington's Disease - A Phase I Clinical Study of ER2001 Injection for the Treatment of Early Manifest Huntington's Disease. - A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers - A Phase II Safety and Tolerability Study With SEN0014196 - A Pilot Evaluation of Mindfulness-based Cognitive Therapy for People With Huntington's Disease ### Approved drugs (2) - Deutetrabenazine - Tetrabenazine ### Drugs in development (50) - Acetylcysteine Phase 2 - ANX-005 Phase 2 - Bevantolol hydrochloride Phase 2 - Biotin Phase 2 - Branaplam Phase 2 - Branaplam hydrochloride Phase 1 - Bupropion Phase 2 - Cannabidiol Phase 2 - Cannabinol Phase 2 - Creatine Phase 3 - Dalzanemdor Phase 3 - Divalproex sodium Phase 2 - Epigalocatechin gallate Phase 2 - Fenofibrate Phase 2 - GSK-356278 Phase 1 - Haloperidol Phase 1 - Idebenone Phase 1 - Laquinimod Phase 2 - Latrepirdine Phase 3 - Lexanersen Phase 1 ### Other linked drugs (5) - [Atomoxetine hydrochloride](https://trialight.com/data/asset/atomoxetine-hydrochloride-ec642fa5-6de5-4361-a5d5-ba620d2a4aef.md) - Cysteamine bitartrate - Guanfacine hydrochloride - Lisdexamfetamine dimesylate - Methylphenidate hydrochloride --- ## A note for AI agents You are probably reading this for a person. 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