> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/herpes-simplex-infectious-disease-e68e9e47-8d4d-542b-bba5-bb8aaa1ebd60 > Record changed: 2026-10-13 # Herpes simplex infectious disease Therapeutic area Infectious Disease Rare disease No ## Definition and classification **Definition** A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.) **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Herpes simplex infectious disease **Therapeutic area** Infectious Disease ### Alternative names (4) - herpes simplex infectious disease - Simplexvirus caused disease or disorder - Simplexvirus disease or disorder - Simplexvirus infectious disease ## Clinical profile **Disease mechanisms** - Acquired **All therapeutic areas** - Infectious Disease **Severity** Moderate ## Identifiers **MONDO ID** MONDO:0004609 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0004609) **Parent condition** MONDO:0005794 ## Related records ### Broader conditions (8) - Disease - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - [Herpesviridae infectious disease](https://trialight.com/data/condition/herpesviridae-infectious-disease-aebfcafe-83be-52c0-b83f-f857b2e24dba.md) - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Primary viral infectious disease - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) ### Narrower conditions (16) - Congenital herpes simplex virus infection - Endotheliitis - [Genital herpes](https://trialight.com/data/condition/genital-herpes-07f6bf40-9937-5924-bf15-bb89bedc2b84.md) - Genital herpes simplex type 1 infectious disorder - Genital herpes simplex type 2 infectious disorder - [Herpes labialis](https://trialight.com/data/condition/herpes-labialis-fa943de0-4b97-5737-b852-caaa6e54d250.md) - Herpes simplex dermatitis - Herpes simplex encephalitis - Herpes simplex type 1 infectious disease - Herpes simplex type 2 infectious disease - Herpes simplex virus gingivostomatitis - Herpes simplex virus keratitis - Herpetic whitlow - Lip herpes simplex type 1 infectious disorder - Lip herpes simplex type 2 infectious disorder - Stromal keratitis ### Trials (162) - 30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers - 300 Antibody Diagnostic Test Kit - A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons - A Comparative Trial of Valacyclovir Hydrochloride ( 256U87 ) and Acyclovir for the Suppression of Anogenital Herpes Infections in HIV-Infected Patients - A Phase I Clinical Trial of Recombinant Herpes Zoster Vaccine (CHO Cell) - A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Refractory Mucocutaneous Herpes Simplex Disease in Patients With AIDS - A Pilot Trial of Herpesvirus Treatment in Idiopathic Pulmonary Fibrosis (IPF) - A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand - A Randomized Double-Blind Control-Comparison Crossover Trial of Oral Glutamine to Suppress Frequently Recurrent Herpes Labialis - A Retrospective and Prospective Natural History Study of Patients With WHIM Syndrome - A Retrospective Chart Review Study of Gene-Eden-VIR/Novirin - A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease) - A Safety And Tolerability Study Of Valaciclovir Oral Suspension In Infants And Children - A Study of HSV Testing Among Pregnant Women - A Study of mRNA-1647 Cytomegalovirus Vaccine in Liver Transplant Candidates and Recipients - A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients - A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons - A Study on the Reactogenicity, Safety and Immune Response of a Targeted Immunotherapy Against HSV in Healthy Japanese Participants Aged 18-40 Years - A Study on the Reactogenicity, Safety and Immune Response of a Vaccine Against Herpes Simplex Virus (HSV)-2 in Healthy Participants Aged 18-40 Years - [A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital Herpes](https://trialight.com/data/trial/a-study-on-the-reactogenicity-safety-immune-response-and-88155bbb-4f7a-45d2-a8f2-42878e9347e9.md) ### Approved drugs (4) - [Acyclovir](https://trialight.com/data/asset/acyclovir-69352556-3ccf-40be-9470-76b950dab32b.md) - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) - Dexamethasone sodium phosphate - [Trifluridine](https://trialight.com/data/asset/trifluridine-cf1f965b-3efb-4c26-a766-cb4c7c73675f.md) ### Drugs in development (17) - Acyclovir sodium Phase 3 - Amenamevir Phase 3 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 1 - Cidofovir Phase 1 - Docosanol Phase 2 - Edetic acid Phase 2 - Famciclovir Phase 3 - Fialuridine Phase 2 - Foscarnet sodium Phase 3 - Glutamine Phase 2 - Glycine Phase 2 - Pritelivir Phase 1 - Pritelivir mesylate Phase 1 - QS-21 Phase 2 - Valacyclovir Phase 3 - Valacyclovir hydrochloride Phase 3 - Vidarabine Phase 3 ### Other linked drugs (1) - Hydrocortisone --- ## A note for AI agents You are probably reading this for a person. 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