> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/herpes-labialis-fa943de0-4b97-5737-b852-caaa6e54d250 > Record changed: 2026-10-13 # Herpes labialis Therapeutic area Infectious Disease Rare disease No ## Definition and classification **Definition** A lesion caused by type 1 or type 2 herpes simplex virus, typically involving the oralfacial region. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Herpes labialis **Therapeutic area** Infectious Disease ### Alternative names (12) - herpes labialis - cold sore - cold sores - herpes labialis - Herpes simplex, labial - Sore, cold - Sores, cold - blister, fever - blisters, fever - fever blister - fever blisters - labial Herpes simplex ## Clinical profile **Disease mechanisms** - Acquired **All therapeutic areas** - Infectious Disease **Severity** Mild ## Identifiers **MONDO ID** MONDO:0043653 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0043653) **Parent condition** MONDO:0004609 ## Related records ### Broader conditions (13) - Disease - Disease arising from reactivation of latent virus - Disease by body system or component - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - [Herpes simplex infectious disease](https://trialight.com/data/condition/herpes-simplex-infectious-disease-e68e9e47-8d4d-542b-bba5-bb8aaa1ebd60.md) - [Herpesviridae infectious disease](https://trialight.com/data/condition/herpesviridae-infectious-disease-aebfcafe-83be-52c0-b83f-f857b2e24dba.md) - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Lip disorder - Mouth disorder - Primary viral infectious disease - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) ### Narrower conditions (2) - Lip herpes simplex type 1 infectious disorder - Lip herpes simplex type 2 infectious disorder ### Trials (52) - A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers - A Double-Blind, Randomized, Placebo-Controlled Study of Topical VDO for the Treatment of Herpes Simplex Labialis - A Multicenter Study of NB-001 in the Treatment of Recurrent Herpes Labialis - A Multicenter Study of NB-001 in the Treatment of Recurrent Herpes Labialis (SHaRCS) - A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis - A Randomized Double-Blind Control-Comparison Crossover Trial of Oral Glutamine to Suppress Frequently Recurrent Herpes Labialis - [A Study to Compare Sitavig (Acyclovir) Buccal Tablet With a Placebo in the Treatment of Herpes Labialis in Participants Whose Immune System Works Normally](https://trialight.com/data/trial/a-study-to-compare-sitavig-acyclovir-buccal-tablet-with-a-2732ad1a-7ae1-4747-b803-17669f43e29d.md) - A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis - An Exploratory Study to Investigate the Inflammatory Response During a Cold Sore Episode - An Investigation Into the Efficacy of Herpecin L at Reducing the Frequency and Severity of Cold Sores - An Open Label Study to Evaluate the Safety and Efficacy of BOR15001L7 for the Treatment of Cold Sores in Patients With Recurrent Herpes Labialis - Bioequivalence Study of Aciclovir 5% Cream in Japanese Healthy Volunteers - Botulinum Toxin A for Herpes Labialis - Clinical Assessment of the Effectiveness and Safety of Herpes Patch SOS in the Treatment of Herpes Simplex Labialis in Comparison to a Competitor's Product. - Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis - Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes Labialis - Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome - Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis - Efficacy of Acyclovir in Combination With a Glucocorticosteroid on UV-Induced Herpes Labialis - Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold Sores ### Approved drugs (9) - [Acyclovir](https://trialight.com/data/asset/acyclovir-69352556-3ccf-40be-9470-76b950dab32b.md) - Camphor - Famciclovir - Hydrocortisone - Menthol - Penciclovir - Phenol - Valacyclovir - Valacyclovir hydrochloride ### Drugs in development (12) - 2-hydroxypropyl-beta-cyclodextrin Phase 2 - Acyclovir sodium Phase 3 - [Alcohol](https://trialight.com/data/asset/alcohol-94acdb16-f595-4fd2-a9fa-0e1509bc9a8f.md) Phase 2 - [Clobetasol](https://trialight.com/data/asset/clobetasol-48798d07-c0c9-4ff6-ac64-7614437eaa22.md) Phase 2 - Glutamine Phase 2 - Glycine Phase 2 - Glycolic acid Phase 2 - Isoxaflutole Phase 2 - NB-001 Phase 3 - Pritelivir Phase 2 - Squaric acid dibutyl ester Phase 2 - ZINC ION Phase 3 ### Other linked drugs (3) - Avobenzone - Onabotulinumtoxina - Zinc oxide --- ## A note for AI agents You are probably reading this for a person. 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